Effect of extracts of poly(ether imide) microparticles on cytotoxicity, ROS generation and proinflammatory effects on human monocytic (THP-1) cells
- A high cell viability of around 99 +/- 18% and 99 +/- 5% was observed when THP-1 cells were cultured in the presence of aqueous extracts of the PEI microparticles in medium A and medium B respectively. The obtained microscopic data suggested that PEI particle extracts have no significant effect on cell death, oxidative stress or differentiation to macrophages. It was further found that the investigated proinflammatory markers in THP-1 cells were not up-regulated. These results are promising with regard to the biocompatibility of PEI microparticles and in a next step the hemocompatibility of the microparticles will be examined.
| Author details: | Reddi K. Kumar, Sayantani Basu, Horst-Dieter Lemke, Joachim Jankowski, Karl KratzORCiD, Andreas LendleinORCiDGND, Sarada D. Tetali |
|---|---|
| DOI: | https://doi.org/10.3233/CH-152027 |
| ISSN: | 1386-0291 |
| ISSN: | 1875-8622 |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/26639770 |
| Title of parent work (English): | Clinical hemorheology and microcirculation : blood flow and vessels |
| Publisher: | IOS Press |
| Place of publishing: | Amsterdam |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2016 |
| Publication year: | 2016 |
| Release date: | 2020/03/22 |
| Tag: | Chronic kidney disease (CKD); cytotoxicity; human monocytic (THP-1) cells; poly(ether imide) microparticles; reactive oxygen species (ROS) |
| Volume: | 61 |
| Number of pages: | 14 |
| First page: | 667 |
| Last Page: | 680 |
| Funding institution: | Indo-German Science and Technology Centre [IGSTC/NPORE/SDT/2012]; German Federal Ministry for Education and Research (BMBF) [01DQ13006A, 01DQ13006B, 01DQ13006C]; IGSTC funded project [IGSTC/NPORE/SDT/2012] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
