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Mothers' prenatal stress and their children's antisocial outcomes - a moderating role for the dopamine receptor D4 (DRD4) gene

  • ResultsUnder conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress. ConclusionsThis study is the first to report a gene-environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior.

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Author details:Katrin Zohsel, Arlette F. Buchmann, Dorothea Blomeyer, Erika Hohm, Martin H. Schmidt, Günter EsserORCiDGND, Daniel Brandeis, Tobias BanaschewskiORCiD, Manfred LauchtGND
DOI:https://doi.org/10.1111/jcpp.12138
ISSN:0021-9630
ISSN:1469-7610
Pubmed ID:https://pubmed.ncbi.nlm.nih.gov/24102377
Title of parent work (English):The journal of child psychology and psychiatry
Publisher:Wiley-Blackwell
Place of publishing:Hoboken
Publication type:Article
Language:English
Year of first publication:2014
Publication year:2014
Release date:2017/03/27
Tag:DRD4; Prenatal stress; antisocial; conduct disorder; gene-environment interaction
Volume:55
Issue:1
Number of pages:8
First page:69
Last Page:76
Funding institution:Lilly; Janssen McNeil; Medice; Novartis; Shire
Organizational units:Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Psychologie
Peer review:Referiert
Institution name at the time of the publication:Humanwissenschaftliche Fakultät / Institut für Psychologie
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