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Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster

  • Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.

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Author:Sören Meyer, Jacqueline Schulz, Astrid Jeibmann, Mojtaba S. Taleshi, Franziska Ebert, Kevin Francesconi, Tanja SchwerdtleORCiDGND
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (183)
Document Type:Postprint
Date of first Publication:2014/09/29
Year of Completion:2014
Release Date:2015/05/13
Tag:arsenolipids present; cod-liver; fatty-acids; fish; identification; oil; rp-hplc
First Page:2010
Last Page:2014
Source:Metallomics, 2014,6, 2010-2014. DOI: 10.1039/C4MT00249K
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Peer Review:Referiert
Publication Way:Open Access
Licence (English):License LogoCreative Commons - Attribution 3.0 Unported
Notes extern:Bibliographieeintrag der Originalveröffentlichung/Quelle