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An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana

  • In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor Regulator of Proteasomal Gene Expression' (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis-element recognized by RPX is evolutionarily conserved between higher plant species. Upon over-expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.

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Author details:Hung M. Nguyen, Jos H. M. Schippers, Oscar Goni-Ramos, Mathias P. Christoph, Hakan Dortay, Renier A. L. van der Hoorn, Bernd Müller-RöberORCiDGND
DOI:https://doi.org/10.1111/tpj.12097
ISSN:0960-7412
Title of parent work (English):The plant journal
Publisher:Wiley-Blackwell
Place of publishing:Hoboken
Publication type:Article
Language:English
Year of first publication:2013
Publication year:2013
Release date:2017/03/26
Tag:Arabidopsis thaliana; evolution; gene regulatory network; leaf development; organ size; proteasome
Volume:74
Issue:1
Number of pages:12
First page:25
Last Page:36
Funding institution:Bundesministerium fur Bildung und Forschung; FKZ [0313924]; Vietnam Ministry of Education and Training; Max Planck Society
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer review:Referiert
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