Enzymatically triggered Jack-in-the-box-like hydrogels
- Enzymes can support the synthesis or degradation of biomacromolecules in natural processes. Here, we demonstrate that enzymes can induce a macroscopic-directed movement of microstructured hydrogels following a mechanism that we call a "Jack-in-the-box" effect. The material's design is based on the formation of internal stresses induced by a deformation load on an architectured microscale, which are kinetically frozen by the generation of polyester locking domains, similar to a Jack-in-thebox toy (i.e., a compressed spring stabilized by a closed box lid). To induce the controlled macroscopic movement, the locking domains are equipped with enzyme-specific cleavable bonds (i.e., a box with a lock and key system). As a result of enzymatic reaction, a transformed shape is achieved by the release of internal stresses. There is an increase in entropy in combination with a swelling-supported stretching of polymer chains within the microarchitectured hydrogel (i.e., the encased clown pops-up with a pre-stressed movement when the box isEnzymes can support the synthesis or degradation of biomacromolecules in natural processes. Here, we demonstrate that enzymes can induce a macroscopic-directed movement of microstructured hydrogels following a mechanism that we call a "Jack-in-the-box" effect. The material's design is based on the formation of internal stresses induced by a deformation load on an architectured microscale, which are kinetically frozen by the generation of polyester locking domains, similar to a Jack-in-thebox toy (i.e., a compressed spring stabilized by a closed box lid). To induce the controlled macroscopic movement, the locking domains are equipped with enzyme-specific cleavable bonds (i.e., a box with a lock and key system). As a result of enzymatic reaction, a transformed shape is achieved by the release of internal stresses. There is an increase in entropy in combination with a swelling-supported stretching of polymer chains within the microarchitectured hydrogel (i.e., the encased clown pops-up with a pre-stressed movement when the box is unlocked). This utilization of an enzyme as a physiological stimulus may offer new approaches to create interactive and enzyme-specific materials for different applications such as an optical indicator of the enzyme's presence or actuators and sensors in biotechnology and in fermentation processes.…
Author details: | Maria BalkGND, Marc BehlORCiDGND, Ulrich NöchelGND, Andreas LendleinORCiDGND |
---|---|
DOI: | https://doi.org/10.1021/acsami.1c00466 |
ISSN: | 1944-8244 |
ISSN: | 1944-8252 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/33555174 |
Title of parent work (English): | ACS applied materials & interfaces / American Chemical Society |
Publisher: | American Chemical Society |
Place of publishing: | Washington, DC |
Publication type: | Article |
Language: | English |
Date of first publication: | 2021/02/08 |
Publication year: | 2021 |
Release date: | 2024/01/03 |
Tag: | enzyme; hydrogels; microporous; poly(e-caprolactone); shape change; stimuli-sensitive materials; switch |
Volume: | 13 |
Issue: | 7 |
Number of pages: | 7 |
First page: | 8095 |
Last Page: | 8101 |
Funding institution: | Helmholtz Association through program-oriented funding Helmholtz Association; Tianjin University-Helmholtz-Zentrum Geesthacht; Joint Laboratory for Biomaterials and Regenerative Medicine by the German Federal Ministry of Education and Research (BMBF)Federal Ministry of Education & Research (BMBF) [0315496]; Chinese Ministry of Science and Technology (MOST)Ministry of Science and Technology, China [2008DFA51170] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
6 Technik, Medizin, angewandte Wissenschaften / 60 Technik / 600 Technik, Technologie | |
Peer review: | Referiert |
Publishing method: | Open Access / Hybrid Open-Access |