Natural product biosyntheses in cyanobacteria a treasure trove of unique enzymes
- Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed fascinating mechanisms that are not, or only rarely, found in other microorganisms. In this article, we survey the biosynthetic pathways of cyanobacteria isolated from freshwater, marine and terrestrial habitats. We especially emphasize modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) pathways and highlight the unique enzyme mechanisms that were elucidated or can be anticipated for the individual products. We further include ribosomal natural products and UV-absorbing pigments from cyanobacteria. Mechanistic insights obtained from the biochemical studies of cyanobacterial pathways can inspire the development of concepts for the design of bioactive compounds by synthetic-biology approaches in the future.
Author details: | Jan-Christoph KehrGND, Douglas Gatte Picchi, Elke Dittmann-ThünemannORCiDGND |
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DOI: | https://doi.org/10.3762/bjoc.7.191 |
ISSN: | 1860-5397 |
Title of parent work (English): | Beilstein journal of organic chemistry |
Publisher: | Beilstein-Institut zur Förderung der Chemischen Wissenschaften |
Place of publishing: | Frankfurt, Main |
Publication type: | Review |
Language: | English |
Year of first publication: | 2011 |
Publication year: | 2011 |
Release date: | 2017/03/26 |
Tag: | NRPS; PKS; cyanobacteria; natural products; ribosomal peptides |
Volume: | 7 |
Issue: | 2 |
Number of pages: | 14 |
First page: | 1622 |
Last Page: | 1635 |
Funding institution: | German Research Foundation (DFG) [Di 910/4-1]; National Council for Scientific and Technological Development (CNPq); Brazilian Ministry of Science and Technology (MCT); German Academic Exchange Service (DAAD) |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
Peer review: | Referiert |
Publishing method: | Open Access |