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Interplay between polymerase II- and polymerase III-assisted expression of overlapping genes

  • Up to 15% of the genes in different genomes overlap. This architecture, although beneficial for the genome size, represents an obstacle for simultaneous transcription of both genes. Here we analyze the interference between RNA-polymerase II (Pol II) and RNA-polymerase III (Pol III) when transcribing their target genes encoded on opposing strands within the same DNA fragment in Arabidopsis thaliana. The expression of a Pol II-dependent protein-coding gene negatively correlated with the transcription of a Pol III-dependent, tRNA-coding gene set. We suggest that the architecture of the overlapping genes introduces an additional layer of control of gene expression. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Author:Radoslaw Lukoszek, Bernd Müller-RöberORCiDGND, Zoya Ignatova
ISSN:0014-5793 (print)
ISSN:1873-3468 (online)
Parent Title (English):FEBS letters : the journal for rapid publication of short reports in molecular biosciences
Place of publication:Amsterdam
Document Type:Article
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:Arabidopsis thaliana; Gene expression; Nested and overlapping genes; Transcription; tRNA
First Page:3692
Last Page:3695
Funder:DFG [FOR 1805]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert