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Aqueous Self-Assembly of Purely Hydrophilic Block Copolymers into Giant Vesicles

  • Self-assembly of macromolecules is fundamental to life itself, and historically, these systems have been primitively mimicked by the development of amphiphilic systems, driven by the hydrophobic effect. Herein, we demonstrate that self-assembly of purely hydrophilic systems can be readily achieved with similar ease and success. We have synthesized double hydrophilic block copolymers from polysaccharides and poly(ethylene oxide) or poly(sarcosine) to yield high molar mass diblock copolymers through oxime chemistry. These hydrophilic materials can easily assemble into nanosized (<500nm) and microsized (>5m) polymeric vesicles depending on concentration and diblock composition. Because of the solely hydrophilic nature of these materials, we expect them to be extraordinarily water permeable systems that would be well suited for use as cellular mimics.

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Metadaten
Author:Sarah M. Brosnan, Helmut SchlaadORCiDGND, Markus AntoniettiORCiDGND
DOI:https://doi.org/10.1002/anie.201502100
ISSN:1433-7851 (print)
ISSN:1521-3773 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=26140384
Parent Title (English):Angewandte Chemie : a journal of the Gesellschaft Deutscher Chemiker ; International edition
Publisher:Wiley-VCH
Place of publication:Weinheim
Document Type:Article
Language:English
Year of first Publication:2015
Year of Completion:2015
Release Date:2017/03/27
Tag:block copolymers; polymersomes; polysaccharides; self-assembly; vesicles
Volume:54
Issue:33
Pagenumber:4
First Page:9715
Last Page:9718
Funder:National Science Foundation (NSF) [DBI-1308104]; Max Planck Society
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert