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DNA origami based Au–Ag-core–shell nanoparticle dimers with single-molecule SERS sensitivity

  • DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 1010, which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.

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Metadaten
Author:Julia PrinzORCiDGND, Christian HeckORCiDGND, Lisa Ellerik, Virginia Merk, Ilko BaldORCiDGND
URN:urn:nbn:de:kobv:517-opus4-89714
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (221)
Document Type:Postprint
Language:English
Date of first Publication:2016/02/11
Year of Completion:2016
Publishing Institution:Universität Potsdam
Release Date:2016/04/12
First Page:5612
Last Page:5620
Source:Nanoscale (2016) Nr. 8, S. 5612-5620. DOI: 10.1039/C5NR08674D
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Peer Review:Referiert
Publication Way:Open Access
Licence (English):License LogoCreative Commons - Attribution 3.0 unported
Notes extern:Bibliographieeintrag der Originalveröffentlichung/Quelle