Synthesis and conformational analysis of phenyl-substituted 1,3,2-oxazaphosphino[4,3-a]- and 1,2,3- oxathiazino[4,3-a]isoquinolines
- Through the ring closures of tetrahydroisoquinoline 1,3-amino alcohols bearing a phenyl group in the side- chain, diastereomers of novel 1- or 2-phenyl-substituted 1,3,2-oxazaphosphino[4,3-a]isoquinoline 4-oxides, and 1,2,3- oxathiazino[4,3-a]isoquinoline 4-oxides and 4,4-dioxides were prepared. NMR analysis and DFT calculations on the prepared tetrahydroisoquinoline-condensed 1,2,3-heterocycles revealed that their conformational equilibria of cis1-trans-cis2 type are influenced by the relative configuration of P-4 in the 1,3,2-oxazaphosphinanes, and by the position of the phenyl group in the 1,2,3-oxathiazines.
Metadaten| Sonstige beteiligte Person(en): | Ildikó Schuster, Andreas Koch, Matthias Heydenreich, Erich Kleinpeter, László Lázár, Ferenc Fueloep |
|---|
| Publikationstyp: | Wissenschaftlicher Artikel |
|---|
| Sprache: | Englisch |
|---|
| Jahr der Erstveröffentlichung: | 2008 |
|---|
| Erscheinungsjahr: | 2008 |
|---|
| Datum der Freischaltung: | 24.03.2017 |
|---|
| Quelle: | Journal of Molecular Structure. - 888 (2008), 1-3, S. 124 - 137 |
|---|
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
|---|
