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Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes: Findings of a longitudinal study from birth to adolescence

  • Variation in the gene encoding for the norepinephrine transporter (NET, SLC6A2) has repeatedly been linked with ADHD, although there is some inconsistency regarding the association with specific genes. The variants for which most consistent association has been found are the NET variants rs3785157 and rs28386840. Here, we tested for their association with ADHD diagnosis and ADHD-related phenotypes during development in a longitudinal German community sample. Children were followed from age 4 to age 15, using diagnostic interviews to assess ADHD. Between the ages of 8 and 15 years, the Child Behavior Checklist (CBCL) was administered to the primary caregivers. The continuous performance task (CPT) was performed at age 15. Controlling for possible confounders, we found that homozygous carriers of the major A allele of the functional promoter variant rs28386840 displayed a higher rate of ADHD lifetime diagnosis. Moreover, homozygous carriers of the minor T allele of rs3785157 were more likely to develop ADHD and showed higher scores onVariation in the gene encoding for the norepinephrine transporter (NET, SLC6A2) has repeatedly been linked with ADHD, although there is some inconsistency regarding the association with specific genes. The variants for which most consistent association has been found are the NET variants rs3785157 and rs28386840. Here, we tested for their association with ADHD diagnosis and ADHD-related phenotypes during development in a longitudinal German community sample. Children were followed from age 4 to age 15, using diagnostic interviews to assess ADHD. Between the ages of 8 and 15 years, the Child Behavior Checklist (CBCL) was administered to the primary caregivers. The continuous performance task (CPT) was performed at age 15. Controlling for possible confounders, we found that homozygous carriers of the major A allele of the functional promoter variant rs28386840 displayed a higher rate of ADHD lifetime diagnosis. Moreover, homozygous carriers of the minor T allele of rs3785157 were more likely to develop ADHD and showed higher scores on the CBCL externalizing behavior scales. Additionally, we found that individuals heterozygous for rs3785157 made fewer omission errors in the CPT than homozygotes. This is the first longitudinal study to report associations between specific NET variants and ADHD-related phenotypes during the course of development. (C) 2015 Elsevier Ireland Ltd. All rights reserved.show moreshow less

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Metadaten
Author:Sarah Hohmann, Erika Hohm, Jens Treutlein, Dorothea Blomeyer, Christine Jennen-Steinmetz, Martin H. Schmidt, Günter EsserGND, Tobias Banaschewski, Daniel Brandeis, Manfred Laucht
DOI:https://doi.org/10.1016/j.psychres.2014.12.029
ISSN:0165-1781 (print)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25724484
Parent Title (English):Psychiatry research : the official publication of the International Society for Neuroimaging in Psychiatry
Publisher:Elsevier
Place of publication:Clare
Document Type:Article
Language:English
Year of first Publication:2015
Year of Completion:2015
Release Date:2017/03/27
Tag:Attention-deficit/hyperactivity disorder; Continuous performance task; Genetic association; Molecular heterosis; Norepinephrine transporter; Polymorphism
Volume:226
Issue:2-3
Pagenumber:9
First Page:425
Last Page:433
Funder:German Research Foundation (DFG) [SFB 258]; Federal Ministry for Education and Research as part of the Baden-Wuerttemberg Consortium for Addiction Research [01EB0110]; National Genome Research Network [01GS0117]
Organizational units:Humanwissenschaftliche Fakultät / Institut für Psychologie
Peer Review:Referiert