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Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy

  • DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.

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Author:Ilko BaldORCiDGND, Adrian Keller
ISSN:1420-3049 (print)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25191873
Parent Title (English):Molecules
Place of publication:Basel
Document Type:Review
Year of first Publication:2014
Year of Completion:2014
Release Date:2017/03/27
Tag:DNA origami; DNA radiation damage; G quadruplexes; atomic force microscopy; enzyme reactions; protein binding; single-molecule analysis
First Page:13803
Last Page:13823
Funder:Marie Curie FP7 Integration Grant within the 7th European Union Framework Programme; Deutsche Forschungsgemeinschaft (DFG)
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert
Publication Way:Open Access