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Feline non-repetitive mitochondrial DNA control region database for forensic evidence

  • The domestic cat is the one of the most popular pets throughout the world. A by-product of owning, interacting with, or being in a household with a cat is the transfer of shed fur to clothing or personal objects. As trace evidence, transferred cat fur is a relatively untapped resource for forensic scientists. Both phenotypic and genotypic characteristics can be obtained from cat fur, but databases for neither aspect exist. Because cats incessantly groom, cat fur may have nucleated cells, not only in the hair bulb, but also as epithelial cells on the hair shaft deposited during the grooming process, thereby generally providing material for DNA profiling. To effectively exploit cat hair as a resource, representative databases must be established. The current study evaluates 402 bp of the mtDNA control region (CR) from 1394 cats, including cats from 25 distinct worldwide populations and 26 breeds. Eighty-three percent of the cats are represented by 12 major mitotypes. An additional 8.0% are clearly derived from the major mitotypes.The domestic cat is the one of the most popular pets throughout the world. A by-product of owning, interacting with, or being in a household with a cat is the transfer of shed fur to clothing or personal objects. As trace evidence, transferred cat fur is a relatively untapped resource for forensic scientists. Both phenotypic and genotypic characteristics can be obtained from cat fur, but databases for neither aspect exist. Because cats incessantly groom, cat fur may have nucleated cells, not only in the hair bulb, but also as epithelial cells on the hair shaft deposited during the grooming process, thereby generally providing material for DNA profiling. To effectively exploit cat hair as a resource, representative databases must be established. The current study evaluates 402 bp of the mtDNA control region (CR) from 1394 cats, including cats from 25 distinct worldwide populations and 26 breeds. Eighty-three percent of the cats are represented by 12 major mitotypes. An additional 8.0% are clearly derived from the major mitotypes. Unique sequences are found in 7.5% of the cats. The overall genetic diversity for this data set is 0.8813 +/- 0.0046 with a random match probability of 11.8%. This region of the cat mtDNA has discriminatory power suitable for forensic application worldwide.show moreshow less

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Author:R. A. Grahn, J. D. Kurushima, N. C. Billings, J. C. Grahn, J. L. Halverson, E. Hammer, C. K. Ho, T. J. Kun, J. K. Levy, M. J. Lipinski, J. M. Mwenda, H. Ozpinar, R. K. Schuster, S. J. Shoorijeh, C. R. Tarditi, N. E. Waly, E. J. Wictum, L. A. Lyons
DOI:https://doi.org/10.1016/j.fsigen.2010.01.013
ISSN:1872-4973 (print)
Parent Title (English):Forensic science international : an international journal dedicated to the applications of genetics in the administration of justice ; Genetics
Publisher:Elsevier
Place of publication:Clare
Document Type:Article
Language:English
Year of first Publication:2011
Year of Completion:2011
Release Date:2017/03/26
Tag:Control region; Domestic cat; Forensic science; Mitochondria; d-Loop; mtDNA
Volume:5
Issue:1
Pagenumber:10
First Page:33
Last Page:42
Funder:NIH-NCRR [R24 RR016094]; UC Davis School of Veterinary Medicine; UC Davis Veterinary Genetics Laboratory; UC Davis Forensic Sciences
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft
Peer Review:Referiert