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Twenty years of active bat rabies surveillance in Germany

  • In Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics andIn Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics and maintenance are discussed.show moreshow less

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Metadaten
Author:J. Schatz, B. Ohlendorf, P. Busse, G. Pelz, D. Dolch, J. Teubner, Jorge A. EncarnacaoORCiD, Ralf -Udo Muehle, M. Fischer, B. Hoffmann, L. Kwasnitschka, Anne Balkema-Buschmann, Thomas Christoph Mettenleiter, T. Mueller, C. M. Freuling
DOI:https://doi.org/10.1017/S0950268813002185
ISSN:0950-2688 (print)
ISSN:1469-4409 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24007822
Parent Title (English):Epidemiology and infection
Subtitle (English):a detailed analysis and future perspectives
Publisher:Cambridge Univ. Press
Place of publication:New York
Document Type:Article
Language:English
Year of first Publication:2014
Year of Completion:2014
Release Date:2017/03/27
Tag:Bat rabies; epidemiology; lyssavirus; surveillance
Volume:142
Issue:6
Pagenumber:12
First Page:1155
Last Page:1166
Funder:German Ministry for Education and Research (BMBF) [01KI1016A]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert
Notes extern:Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 533