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Robustness of metabolic networks a review of existing definitions

  • Describing the determinants of robustness of biological systems has become one of the central questions in systems biology. Despite the increasing research efforts, it has proven difficult to arrive at a unifying definition for this important concept. We argue that this is due to the multifaceted nature of the concept of robustness and the possibility to formally capture it at different levels of systemic formalisms (e.g, topology and dynamic behavior). Here we provide a comprehensive review of the existing definitions of robustness pertaining to metabolic networks. As kinetic approaches have been excellently reviewed elsewhere, we focus on definitions of robustness proposed within graph-theoretic and constraint-based formalisms.

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Author details:Abdelhalim Larhlimi, Sylvain Blachon, Joachim SelbigGND, Zoran NikoloskiORCiDGND
DOI:https://doi.org/10.1016/j.biosystems.2011.06.002
ISSN:0303-2647
Title of parent work (English):Biosystems : journal of biological and information processing sciences
Publisher:Elsevier
Place of publishing:Oxford
Publication type:Review
Language:English
Year of first publication:2011
Publication year:2011
Release date:2017/03/26
Tag:Constraint-based approaches; Graph theory; Metabolic networks; Robustness
Volume:106
Issue:1
Number of pages:8
First page:1
Last Page:8
Funding institution:GABI-ENERGY; Federal Ministry of Education and Research [0315045, 0313924]; GoFORSYS
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer review:Referiert
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