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Naphthoquinones from the roots of Aloe secundiflora

  • Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid D methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21-23 mu g/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50 = 10.2 mu g/mL).

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Author:Martha Induli, Michael Cheloti, Antonina Wasuna, Ingrid Wekesa, John M. Wanjohi, Robert Byamukama, Matthias Heydenrich, Moses Makayoto, Abiy Yenesew
ISSN:1874-3900 (print)
Parent Title (English):Phytochemistry letters
Place of publication:Amsterdam
Document Type:Article
Year of first Publication:2012
Year of Completion:2012
Release Date:2017/03/26
Tag:5-Hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione 5,8-Dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione; Aloe secundiflora; Aloesaponarin I; Anthraquinone; Asphodelaceae; Mycobacterium tuberculosis; Naphthoquinone; Roots
First Page:506
Last Page:509
Funder:German Academic Exchange Services (DAAD) through the Natural Products Research Network for Eastern and Central Africa (NAPRECA); Kenya Industrial Research and Development Institute (KIRDI)
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert