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The history of the discovery of the molybdenum cofactor and novel aspects of its biosynthesis in bacteria

  • The biosynthesis of the molybdenum cofactor in bacteria is described with a detailed analysis of each individual reaction leading to the formation of stable intermediates during the synthesis of molybdopterin from GTP. As a starting point, the discovery of molybdopterin and the elucidation of its structure through the study of stable degradation products are described. Subsequent to molybdopterin synthesis, the molybdenum atom is added to the molybdopterin dithiolene group to form the molybdenum cofactor. This cofactor is either inserted directly into specific molybdoenzymes or is further modified by the addition of nucleotides to molybdopterin phosphate group or the replacement of ligands at the molybdenum center.

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Metadaten
Author:Silke Leimkühler, Margot M. Wuebbens, K. V. Rajagopalan
DOI:https://doi.org/10.1016/j.ccr.2010.12.003
ISSN:0010-8545 (print)
Parent Title (English):Coordination chemistry reviews
Publisher:Elsevier
Place of publication:Lausanne
Document Type:Review
Language:English
Year of first Publication:2011
Year of Completion:2011
Release Date:2017/03/26
Tag:Dithiolene group; Molybdenum cofactor; Molybdopterin; Molybdopterin guanine dinucleotide cofactor; Precursor Z; Urothione
Volume:255
Issue:9-10
Pagenumber:16
First Page:1129
Last Page:1144
Funder:Deutsche Forschungsgemeinschaft; NIH
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert