Antonia Graja, Francisco Garcia-Carrizo, Anne-Marie Jank, Sabrina Gohlke, Thomas H. Ambrosi, Wenke Jonas, Siegfried Ussar, Matthias Kern, Annette Schürmann, Krasimira Aleksandrova, Matthias Bluher, Tim Julius Schulz
- Remodeling of the extracellular matrix is a key component of the metabolic adaptations of adipose tissue in response to dietary and physiological challenges. Disruption of its integrity is a well-known aspect of adipose tissue dysfunction, for instance, during aging and obesity. Adipocyte regeneration from a tissue-resident pool of mesenchymal stem cells is part of normal tissue homeostasis. Among the pathophysiological consequences of adipogenic stem cell aging, characteristic changes in the secretory phenotype, which includes matrix-modifying proteins, have been described. Here, we show that the expression of the matricellular protein periostin, a component of the extracellular matrix produced and secreted by adipose tissue-resident interstitial cells, is markedly decreased in aged brown and white adipose tissue depots. Using a mouse model, we demonstrate that the adaptation of adipose tissue to adrenergic stimulation and high-fat diet feeding is impaired in animals with systemic ablation of the gene encoding for periostin. Our dataRemodeling of the extracellular matrix is a key component of the metabolic adaptations of adipose tissue in response to dietary and physiological challenges. Disruption of its integrity is a well-known aspect of adipose tissue dysfunction, for instance, during aging and obesity. Adipocyte regeneration from a tissue-resident pool of mesenchymal stem cells is part of normal tissue homeostasis. Among the pathophysiological consequences of adipogenic stem cell aging, characteristic changes in the secretory phenotype, which includes matrix-modifying proteins, have been described. Here, we show that the expression of the matricellular protein periostin, a component of the extracellular matrix produced and secreted by adipose tissue-resident interstitial cells, is markedly decreased in aged brown and white adipose tissue depots. Using a mouse model, we demonstrate that the adaptation of adipose tissue to adrenergic stimulation and high-fat diet feeding is impaired in animals with systemic ablation of the gene encoding for periostin. Our data suggest that loss of periostin attenuates lipid metabolism in adipose tissue, thus recapitulating one aspect of age-related metabolic dysfunction. In human white adipose tissue, periostin expression showed an unexpected positive correlation with age of study participants. This correlation, however, was no longer evident after adjusting for BMI or plasma lipid and liver function biomarkers. These findings taken together suggest that age-related alterations of the adipose tissue extracellular matrix may contribute to the development of metabolic disease by negatively affecting nutrient homeostasis.…
MetadatenAuthor details: | Antonia GrajaGND, Francisco Garcia-CarrizoORCiD, Anne-Marie JankGND, Sabrina GohlkeGND, Thomas H. AmbrosiGND, Wenke JonasORCiDGND, Siegfried UssarGND, Matthias Kern, Annette SchürmannORCiDGND, Krasimira AleksandrovaORCiDGND, Matthias Bluher, Tim Julius SchulzORCiDGND |
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DOI: | https://doi.org/10.1111/acel.12810 |
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ISSN: | 1474-9718 |
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ISSN: | 1474-9726 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30088333 |
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Title of parent work (English): | Aging Cell |
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Publisher: | Wiley |
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Place of publishing: | Hoboken |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2018/08/07 |
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Publication year: | 2018 |
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Release date: | 2021/09/22 |
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Tag: | adipogenic progenitor cells; adipose tissue; aging; extracellular matrix; fatty acid metabolism; periostin |
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Volume: | 17 |
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Issue: | 5 |
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Number of pages: | 13 |
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Funding institution: | Bundesministerium fur Bildung und Forschung (BMBF)Federal Ministry of Education & Research (BMBF); Bundesland Brandenburg [82DZD00302]; Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SCHU 2445/2-1]; European Research CouncilEuropean Research Council (ERC) [ERC-StG 311082]; Helmholtz AssociationHelmholtz Association |
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Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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License (German): | CC-BY - Namensnennung 4.0 International |
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