Miriam Sebold, G. Spitta, T. Gleich, T. Dembler-Stamm, Oisin Butler, Kristin Zacharias, S. Aydin, Maria Garbusow, Michael A. Rapp, Florian Schubert, Ralph Buchert, Jürgen Gallinat, Andreas Heinz
- Stress plays a key role in modulating addictive behavior and can cause relapse following periods of abstinence. Common effects of stress and alcohol on the dopaminergic system have been suggested, although the precise mechanisms are unclear. Here, we investigated 20 detoxified alcohol-dependent patients and 19 matched healthy controls and assessed striatal D2/D3 availability using [F-18]-fallypride positron emission tomography and stressful life events. We found a strong association between striatal D2/D3 availability and stress in patients, but not in healthy controls. Interestingly, we found increased D2/D3 receptor availability in patients with higher stress levels. This mirrors complex interactions between stress and alcohol intake in animal studies and emphasizes the importance to investigate stress exposure in neurobiological studies of addiction.
MetadatenAuthor details: | Miriam SeboldORCiDGND, G. Spitta, T. Gleich, T. Dembler-Stamm, Oisin ButlerGND, Kristin ZachariasGND, S. Aydin, Maria GarbusowORCiDGND, Michael A. RappORCiDGND, Florian SchubertORCiD, Ralph BuchertORCiDGND, Jürgen GallinatGND, Andreas HeinzORCiDGND |
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DOI: | https://doi.org/10.1007/s00702-019-01985-2 |
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ISSN: | 0300-9564 |
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ISSN: | 1435-1463 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30747311 |
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Title of parent work (English): | Journal of neural transmission |
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Publisher: | Springer |
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Place of publishing: | Wien |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2019/02/12 |
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Publication year: | 2019 |
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Release date: | 2020/11/30 |
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Tag: | Alcohol dependence; D3 receptor; Dopamine D2; Positron emission tomography; Stressful life events; Striatum |
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Volume: | 126 |
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Issue: | 9 |
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Number of pages: | 8 |
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First page: | 1127 |
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Last Page: | 1134 |
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Funding institution: | German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)German Research Foundation (DFG) [FOR 1617, HE 2597/14-1, HE 2597/15-1, HE 2597/14-2, HE 2597/15-2, GA 707/6-1, RA 1047/2-1, RA 1047/2-2] |
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Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
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DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer review: | Referiert |
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Institution name at the time of the publication: | Humanwissenschaftliche Fakultät / Institut für Sportmedizin und Prävention |
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