Associations of short stature and components of height with incidence of type 2 diabetes
- Aims/hypothesis This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. Methods A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. Results After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among menAims/hypothesis This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. Methods A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. Results After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among men and women, but only among men if adjusted for total height. Adjustment for liver fat and triacylglycerols, adiponectin and C-reactive protein substantially attenuated associations between height and diabetes risk, particularly among women. Conclusions/interpretation We observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile.…
Author details: | Clemens WittenbecherORCiDGND, Olga Kuxhaus, Heiner BoeingORCiDGND, Norbert StefanORCiDGND, Matthias Bernd SchulzeORCiDGND |
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DOI: | https://doi.org/10.1007/s00125-019-04978-8 |
ISSN: | 0012-186X |
ISSN: | 1432-0428 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31501920 |
Title of parent work (English): | Diabetologia : journal of the European Association for the Study of Diabetes (EASD) |
Subtitle (German): | mediating effects of cardiometabolic risk factors |
Publisher: | Springer |
Place of publishing: | New York |
Publication type: | Article |
Language: | English |
Year of first publication: | 2019 |
Publication year: | 2019 |
Release date: | 2020/09/28 |
Tag: | Adult height; Blood pressure; Diabetes incidence; Leg length; Liver fat; Short stature; Trunk length |
Volume: | 62 |
Issue: | 12 |
Number of pages: | 11 |
First page: | 2211 |
Last Page: | 2221 |
Funding institution: | Federal Ministry of Science, Germany [01 EA 9401]; European UnionEuropean Union (EU) [SOC 95201408 05F02]; German Cancer AidDeutsche Krebshilfe [70-2488-Ha I]; European CommunityEuropean Community (EC) [SOC 98200769 05F02]; German Ministry of Education and Research (BMBF)Federal Ministry of Education & Research (BMBF); State of Brandenburg (DZD) [82DZD00302] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
DDC classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Peer review: | Referiert |
Publishing method: | Open Access |
Open Access / Hybrid Open-Access |