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Twenty years of active bat rabies surveillance in Germany

  • In Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics andIn Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics and maintenance are discussed.show moreshow less

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Metadaten
Author:Juliane Schatz, Bernd Ohlendorf, Peter Busse, Gerrit Pelz, Dietrich Dolch, Jens Teubner, Jorge A. EncarnacaoORCiD, Ralf-Udo Mühle, M. Fischer, Bernd Hoffmann, Linda Kwasnitschka, Anne Balkema-Buschmann, Thomas Christoph Mettenleiter, T. Müller, Conrad M. Freuling
URN:urn:nbn:de:kobv:517-opus4-415140
DOI:https://doi.org/10.25932/publishup-41514
ISSN:1866-8364
Parent Title (English):Postprints der Universität Potsdam Humanwissenschaftliche Reihe
Subtitle (English):a detailed analysis and future perspectives
Series (Serial Number):Postprints der Universität Potsdam : Humanwissenschaftliche Reihe (533)
Document Type:Postprint
Language:English
Date of first Publication:2019/02/14
Year of Completion:2013
Publishing Institution:Universität Potsdam
Release Date:2019/02/14
Tag:Bat rabies; epidemiology; lyssavirus; surveillance
Issue:533
Pagenumber:12
Source:Epidemiology and Infection 142 (2014) 6, S. 1155–1166 DOI: 10.1017/S0950268813002185
Organizational units:Humanwissenschaftliche Fakultät
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Peer Review:Referiert
Publication Way:Open Access
Grantor:Cambridge University Press (CUP)
Licence (German):License LogoKeine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht
Notes extern:Bibliographieeintrag der Originalveröffentlichung/Quelle