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Mothers' prenatal stress and their children's antisocial outcomes - a moderating role for the dopamine receptor D4 (DRD4) gene

  • ResultsUnder conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress. ConclusionsThis study is the first to report a gene-environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior.

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Author:Katrin Zohsel, Arlette F. Buchmann, Dorothea Blomeyer, Erika Hohm, Martin H. Schmidt, Günter EsserGND, Daniel Brandeis, Tobias Banaschewski, Manfred Laucht
ISSN:0021-9630 (print)
ISSN:1469-7610 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24102377
Parent Title (English):The journal of child psychology and psychiatry
Place of publication:Hoboken
Document Type:Article
Year of first Publication:2014
Year of Completion:2014
Release Date:2017/03/27
Tag:DRD4; Prenatal stress; antisocial; conduct disorder; gene-environment interaction
First Page:69
Last Page:76
Funder:Lilly; Janssen McNeil; Medice; Novartis; Shire
Organizational units:Humanwissenschaftliche Fakultät / Institut für Psychologie
Peer Review:Referiert