Angela Heinrich, Arlette F. Buchmann, Katrin Zohsel, Helene Dukal, Josef Frank, Jens Treutlein, Vanessa Nieratschker, Stephanie H. Witt, Daniel Brandeis, Martin H. Schmidt, Günter Esser, Tobias Banaschewski, Manfred Laucht, Marcella Rietschel
- Epigenetic modulations are a hypothesized link between environmental factors and the development of psychiatric disorders. Research has suggested that patients with depression or bipolar disorder exhibit higher methylation levels in the glucocorticoid receptor gene NR3C1. We aimed to investigate whether NR3C1 methylation changes are similarly associated with externalizing disorders such as aggressive behavior and conduct disorder. NR3C1 exon 1F methylation was analyzed in young adults with a lifetime diagnosis of an externalizing disorder (N = 68) or a depressive disorder (N = 27) and healthy controls (N = 124) from the Mannheim Study of Children at Risk. The externalizing disorders group had significantly lower NR3C1 methylation levels than the lifetime depressive disorder group (p = 0.009) and healthy controls (p = 0.001) This report of lower methylation levels in NR3C1 in externalizing disorders may indicate a mechanism through which the differential development of externalizing disorders as opposed to depressive disorders mightEpigenetic modulations are a hypothesized link between environmental factors and the development of psychiatric disorders. Research has suggested that patients with depression or bipolar disorder exhibit higher methylation levels in the glucocorticoid receptor gene NR3C1. We aimed to investigate whether NR3C1 methylation changes are similarly associated with externalizing disorders such as aggressive behavior and conduct disorder. NR3C1 exon 1F methylation was analyzed in young adults with a lifetime diagnosis of an externalizing disorder (N = 68) or a depressive disorder (N = 27) and healthy controls (N = 124) from the Mannheim Study of Children at Risk. The externalizing disorders group had significantly lower NR3C1 methylation levels than the lifetime depressive disorder group (p = 0.009) and healthy controls (p = 0.001) This report of lower methylation levels in NR3C1 in externalizing disorders may indicate a mechanism through which the differential development of externalizing disorders as opposed to depressive disorders might occur.…
MetadatenAuthor details: | Angela Heinrich, Arlette F. Buchmann, Katrin Zohsel, Helene Dukal, Josef Frank, Jens Treutlein, Vanessa Nieratschker, Stephanie H. Witt, Daniel Brandeis, Martin H. Schmidt, Günter EsserORCiDGND, Tobias BanaschewskiORCiD, Manfred LauchtGND, Marcella Rietschel |
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DOI: | https://doi.org/10.1007/s10519-015-9721-y |
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ISSN: | 0001-8244 |
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ISSN: | 1573-3297 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25894927 |
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Title of parent work (English): | Behavior genetics : an international journal devoted to research in the inheritance of behavior in animals and man |
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Publisher: | Springer |
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Place of publishing: | New York |
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Publication type: | Article |
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Language: | English |
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Year of first publication: | 2015 |
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Publication year: | 2015 |
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Release date: | 2017/03/27 |
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Tag: | Adolescents; Epigenetic; Externalizing disorders; Glucocorticoid receptor; Methylation |
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Volume: | 45 |
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Issue: | 5 |
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Number of pages: | 8 |
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First page: | 529 |
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Last Page: | 536 |
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Funding institution: | German Ministry of Education and Research within National Genome
Research Network plus (NGFNplus); MooDS-Net [01GS08147];
Olympia-Morata-Program of the University of Heidelberg |
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Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Psychologie |
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Peer review: | Referiert |
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Institution name at the time of the publication: | Humanwissenschaftliche Fakultät / Institut für Psychologie |
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