Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster
- Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.
| Author details: | Sören MeyerGND, J. Schulz, A. Jeibmann, M. S. Taleshi, Franziska EbertORCiDGND, Kevin A. FrancesconiORCiD, Tanja SchwerdtleORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1039/c4mt00249k |
| ISSN: | 1756-5901 |
| ISSN: | 1756-591X |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25292248 |
| Title of parent work (English): | Metallomics : integrated biometal science |
| Publisher: | Royal Society of Chemistry |
| Place of publishing: | Cambridge |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2014 |
| Publication year: | 2014 |
| Release date: | 2017/03/27 |
| Volume: | 6 |
| Issue: | 11 |
| Number of pages: | 5 |
| First page: | 2010 |
| Last Page: | 2014 |
| Funding institution: | DFG [SCHW903/4-1]; Austrian Science Fund (FWF) [I550-N17]; Graduate School of Chemistry (University of Muenster, Germany) |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
| Peer review: | Referiert |
