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Antiplasmodial β-hydroxydihydrochalcone from seedpods of Tephrosia elata

  • From the seedpods of Tephrosia elata, a new β-hydroxydihydrochalcone named (S)-elatadihydrochalcone was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether and deguelin were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial activities. The literature NMR data on β-hydroxydihydrochalcones is reviewed and the identity of some of the compounds assigned β-hydroxydihydrochalcone skeleton is questioned.

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Author:Martin G. Peter, Lois M. Muiva, Abiy Yenesew, Solomon DereseORCiD, Matthias Heydenreich, Hoseah M. Akala, Fredrick Eyase, Norman C. Waters, Charles Mutai, Joseph M. Keriko, Douglas S. Walsh
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (paper 118)
Document Type:Postprint
Year of Completion:2009
Publishing Institution:Universität Potsdam
Release Date:2010/07/05
Tag:(S)-Elatadihydrochalcone; Leguminosae; Seedpods; Tephrosia elata; β-Hydroxydihydrochalcone
Source:Phytochemistry letters 2 (2009), 3, S. 99 - 102, DOI 10.1016/j.phytol.2009.01.002
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Licence (German):License LogoKeine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht
Notes extern:
The article was originally published by:
Phytochemistry letters. - 2 (2009), 3, S. 99-102
ISSN 1874-3900
DOI 10.1016/j.phytol.2009.01.002