Molecular processes studied at a single-molecule level using DNA origami nanostructures and atomic force microscopy
- DNA origami nanostructures allow for the arrangement of different functionalities such as proteins, specific DNA structures, nanoparticles, and various chemical modifications with unprecedented precision. The arranged functional entities can be visualized by atomic force microscopy (AFM) which enables the study of molecular processes at a single-molecular level. Examples comprise the investigation of chemical reactions, electron-induced bond breaking, enzymatic binding and cleavage events, and conformational transitions in DNA. In this paper, we provide an overview of the advances achieved in the field of single-molecule investigations by applying atomic force microscopy to functionalized DNA origami substrates.
Download full text files
SHA-512:f1a97897a8d59cb3290acd8983dc635cb39dfb5bf58f8372ad170ade6964b43bbf5d23f2d1bd2bbfc177bc5fd66325acf50fef8776fcc8f1f2ec94cc6875faf0
Additional Services
| Author details: | Ilko BaldORCiDGND, Adrian KellerORCiD |
|---|---|
| URN: | urn:nbn:de:kobv:517-opus4-475843 |
| DOI: | https://doi.org/10.25932/publishup-47584 |
| ISSN: | 1866-8372 |
| Title of parent work (German): | Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe |
| Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (1146) |
| Publication type: | Postprint |
| Language: | English |
| Date of first publication: | 2021/09/08 |
| Publication year: | 2014 |
| Publishing institution: | Universität Potsdam |
| Release date: | 2021/09/08 |
| Tag: | DNA origami; DNA radiation damage; G quadruplexes; atomic force microscopy; enzyme reactions; protein binding; single-molecule analysis |
| Issue: | 9 |
| Number of pages: | 21 |
| First page: | 13803 |
| Last Page: | 13823 |
| Source: | Molecules 19 (2014) 9, 13803-13823 DOI: 10.3390/molecules190913803 |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
| Publishing method: | Open Access / Green Open-Access |
| License (German): |  CC-BY - Namensnennung 4.0 International |
| External remark: | Bibliographieeintrag der Originalveröffentlichung/Quelle |
