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3-Oxo-14 alpha, 15 alpha-epoxyschizozygine: A new schizozygane indoline alkaloid from Schizozygia coffaeoides

  • The stem bark extract of Schizozygia coffaeoides (Apocynaceae) showed moderate antiplasmodial activity (IC50 = 8-12 mu g/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new schizozygane indoline alkaloid, named 3-oxo-14 alpha, 15 alpha-epoxyschizozygine. In addition, two dimeric anthraquinones, cassiamin A and cassiamin B, were identified for the first time in the family Apocynaceae. The structures of the isolated compounds were deduced on the basis of spectroscopic evidence. The schizozygane indole alkaloids showed good to moderate antiplasmodial activities (IC50 = 13-52 mu m). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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Author:Yoseph Atilaw, Matthias Heydenreich, Albert Ndakala, Hoseah M. Akala, Edwin Kamau, Abiy Yenesew
ISSN:1874-3900 (print)
ISSN:1876-7486 (online)
Parent Title (English):Phytochemistry letters
Place of publication:Amsterdam
Document Type:Article
Year of first Publication:2014
Year of Completion:2014
Release Date:2017/03/26
Tag:3-Oxo-14 alpha, 15 alpha-epoxyschizozygine; Cassiamin A; Cassiamin B; Dimeric anthraquinone; Schizozygane indoline alkaloid; Schizozygia coffaeoides
First Page:28
Last Page:31
Funder:German Academic Exchange Services (DAAD) through Natural Products Research Network for Eastern and Central Africa (NAPRECA); International Science Program (ISP, Sweden) [KEN-02]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert