Childhood adversity impacts on brain subcortical structures relevant to depression

  • Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumesChildhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression. (C) 2016 Published by Elsevier Ltd.show moreshow less

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Author details:Thomas Frodl, Deborah Janowitz, Lianne Schmaal, Leonardo TozziORCiD, Henrik Dobrowolny, Dan J. Stein, Dick J. Veltman, Katharina Wittfeld, Theo G. M. van Erp, Neda Jahanshad, Andrea BlockORCiDGND, Katrin Hegenscheid, Henry Voelzke, Jim Lagopoulos, Sean N. Hatton, Ian B. Hickie, Eva Maria Frey, Angela Carballedo, Samantha J. Brooks, Daniella Vuletic, Anne Uhlmann, Ilya M. Veer, Henrik Walter, Knut Schnell, Dominik Grotegerd, Volker Arolt, Harald Kugel, Elisabeth Schramm, Carsten Konrad, Bartosz Zurowski, Bernhard T. Baune, Nic J. A. van der Wee, Marie-Jose van Tol, Brenda W. J. H. Penninx, Paul M. Thompson, Derrek P. Hibar, Udo DannlowskiORCiD, Hans J. Grabe
DOI:https://doi.org/10.1016/j.jpsychires.2016.11.010
ISSN:0022-3956
ISSN:1879-1379
Pubmed ID:http://www.ncbi.nlm.nih.gov/pubmed?term=27918926
Title of parent work (English):Journal of psychiatric research
Publisher:Elsevier
Place of publishing:Oxford
Publication type:Article
Language:English
Date of first publication:2016/12/02
Publication year:2017
Release date:2022/06/23
Tag:Caudate; Childhood adversity; Depression; ENIGMA; Hippocampus; MRI
Volume:86
Number of pages:8
First page:58
Last Page:65
Organizational units:Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Psychologie
DDC classification:1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie
Peer review:Referiert
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