Advances in the biofabrication of 3D Skin in vitro

  • The relevance for in vitro three-dimensional (3D) tissue culture of skin has been present for almost a century. From using skin biopsies in organ culture, to vascularized organotypic full-thickness reconstructed human skin equivalents, in vitro tissue regeneration of 3D skin has reached a golden era. However, the reconstruction of 3D skin still has room to grow and develop. The need for reproducible methodology, physiological structures and tissue architecture, and perfusable vasculature are only recently becoming a reality, though the addition of more complex structures such as glands and tactile corpuscles require advanced technologies. In this review, we will discuss the current methodology for biofabrication of 3D skin models and highlight the advantages and disadvantages of the existing systems as well as emphasize how new techniques can aid in the production of a truly physiologically relevant skin construct for preclinical innovation.

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Author details:Matthew J. RandallORCiD, Astrid Jüngel, Markus RimannORCiD, Karin Wuertz-KozakORCiD
Pubmed ID:
Title of parent work (English):Frontiers in Bioengineeringand Biotechnology
Subtitle (English):healthy and pathological models
Publisher:Frontiers Research Foundation
Place of publishing:Lausanne
Publication type:Review
Date of first publication:2018/10/31
Completion year:2018
Release date:2021/07/20
Number of pages:12
Funding institution:Innosuisse Project [25980]
Organizational units:Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften
DDC classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Peer review:Referiert
Publishing method:Open Access / Gold Open-Access
DOAJ gelistet
External remark:Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Postprints der Universität Potsdam : Humanwissenschaftliche Reihe ; 680