Impaired proteostasis during skeletal muscle aging

  • Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The skeletal muscle is one of the earliest tissues to be affected and to manifest age-related changes such as functional impairment and the loss of mass. Common to these alterations and to most of tissues during aging is the disruption of the proteostasis network by detrimental changes in the ubiquitin-proteasomal system (UPS) and the autophagy-lysosomal system (ALS). In fact, during aging the accumulation of protein aggregates, a process mainly driven by increased levels of oxidative stress, has been observed, clearly demonstrating UPS and ALS dysregulation. Since the UPS and ALS are the two most important pathways for the removal of misfolded and aggregated proteins and also of damaged organelles, we provide here an overview on the current knowledge regarding the connection between the loss of proteostasis and skeletal muscle functional impairment and also how redox regulation can play a role during aging. Therefore, this review serves for a betterAging is a complex phenomenon that has detrimental effects on tissue homeostasis. The skeletal muscle is one of the earliest tissues to be affected and to manifest age-related changes such as functional impairment and the loss of mass. Common to these alterations and to most of tissues during aging is the disruption of the proteostasis network by detrimental changes in the ubiquitin-proteasomal system (UPS) and the autophagy-lysosomal system (ALS). In fact, during aging the accumulation of protein aggregates, a process mainly driven by increased levels of oxidative stress, has been observed, clearly demonstrating UPS and ALS dysregulation. Since the UPS and ALS are the two most important pathways for the removal of misfolded and aggregated proteins and also of damaged organelles, we provide here an overview on the current knowledge regarding the connection between the loss of proteostasis and skeletal muscle functional impairment and also how redox regulation can play a role during aging. Therefore, this review serves for a better understanding of skeletal muscle aging in regard to the loss of proteostasis and how redox regulation can impact its function and maintenance.show moreshow less

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Author details:Raquel Fernando, Cathleen Drescher, Kerstin NowotnyGND, Tilman GruneORCiDGND, Jose Pedro CastroORCiD
DOI:https://doi.org/10.1016/j.freeradbiomed.2018.08.037
ISSN:0891-5849
ISSN:1873-4596
Pubmed ID:http://www.ncbi.nlm.nih.gov/pubmed?term=30194981
Title of parent work (English):Free radical biology and medicine : the official journal of the Oxygen Society, a constituent member of the International Society for Free Radical Research
Publisher:Elsevier
Place of publishing:New York
Publication type:Article
Language:English
Date of first publication:2018/09/05
Completion year:2018
Release date:2021/04/07
Tag:Aging; Oxidative stress; Proteasome and lysosome; Proteostasis; Redox regulation; Skeletal muscle
Volume:132
Page number:9
First page:58
Last Page:66
Funding institution:German Research Foundation (DFG)German Research Foundation (DFG) [Gr1240/16-1, Gr1240/18-1]; Ministerium fur Wissenschaft, Forschung und Kultur (Gesundheitscampus Brandenburg)
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft
DDC classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit
Peer review:Referiert
Publishing method:Open Access / Hybrid Open-Access
License (German):License LogoCreative Commons - Namensnennung, Nicht kommerziell, Keine Bearbeitung 4.0 International