Scaling Up UV-Mediated Intramolecular Photodehydro-Diels-Alder Reactions Using a Homemade High-Performance Annular Continuous-Flow Reactor

  • Here we present a self-made annular continuous-flow reactor that can be used in the UV/vis range in an internal numbering-up manner. As a model reaction, we chose a powerful batch-scale-limited benzoannelation method, namely, an intramolecular photodehydro-Diels-Alder (IMPDDA) reaction. The scale-up potential of this particular photochemical benchmark reaction toward the preparation of macrocylic (1,7)naphthalenophanes by variation of selected flow parameters is presented.

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Author details:Maciej CzarneckiORCiD, Pablo WessigORCiDGND
Parent title (English):Organic Process Research & Development
Publisher:American Chemical Society
Place of publication:Washington
Document type:Article
Date of first publication:2018/11/20
Year of completion:2018
Release date:2021/01/13
Tag:flow photochemistry; photocycloaddition; photodehydro-Diels-Alder reaction; scale-up
Page number:5
First page:1823
Last Page:1827
Funder:Deutsche Forschungsgemeinschaft
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
DDC classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Peer review:Referiert
License (German):License LogoKeine Nutzungslizenz vergeben - es gilt das deutsche Urheberrecht