EDTA and NTA effectively tune the mineralization of calcium phosphate from bulk aqueous solution

  • This study describes the effects of nitrilotriacetic acid (NTA) and ethylenediaminotetraacetic acid (EDTA) on themineralization of calciumphosphate from bulk aqueous solution. Mineralization was performed between pH 6 and 9 and with NTA or EDTA concentrations of 0, 5, 10, and 15 mM. X-ray diffraction and infrared spectroscopy show that at low pH, mainly brushite precipitates and at higher pH, mostly hydroxyapatite forms. Both additives alter the morphology of the precipitates. Without additive, brushite precipitates as large plates. With NTA, the morphology changes to an unusual rod-like shape. With EDTA, the edges of the particles are rounded and disk-like particles form. Conductivity and pH measurements suggest that the final products form through several intermediate steps.

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Author:Doreen HentrichORCiDGND, Klaus TauerORCiD, Montserrat Espanol, Maria-Pau GinebraORCiD, Andreas TaubertORCiDGND
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=31105185
Parent Title (English):Biomimetics : open access journal
Place of publication:Basel
Document Type:Article
Year of first Publication:2017
Year of Completion:2017
Release Date:2020/05/15
Tag:EDTA; NTA; biomimetic mineralization; biomineralization; brushite; calcium phosphate; hydroxyapatite; precipitation
Funder:University of Potsdam; Max Planck Institute of Colloids and Interfaces
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer Review:Referiert
Publication Way:Open Access
Open Access / Gold Open-Access
DOAJ gelistet
Licence (German):License LogoCreative Commons - Namensnennung, 4.0 International
Notes extern:Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : [Titel der Postprintreihe] ; [Ausgabe der Postprintreihe]