Biomineralization of engineered spider silk protein-based composite materials for bone tissue engineering

  • Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT) or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)), that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering.

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Author:John G. Hardy, Jose Guillermo Torres-Rendon, Aldo Leal-Egaña, Andreas Walther, Helmut SchlaadORCiDGND, Helmut CölfenGND, Thomas R. Scheibel
Series (Serial Number):Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe (359)
Document Type:Postprint
Date of first Publication:2017/09/22
Year of Completion:2017
Publishing Institution:Universität Potsdam
Release Date:2017/09/22
Tag:biodegradable polymers; biomaterials; biomineralization; bone tissue engineering; recombinant protein; spider silk
Source:Materials 9 (2016) Nr. 7. - DOI: 10.3390/ma9070560
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 60 Technik / 600 Technik, Technologie
Peer Review:Referiert
Publication Way:Open Access
Grantor:Multidisciplinary Digital Publishing Institute (MDPI)
Licence (German):License LogoCreative Commons - Namensnennung, 4.0 International