Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders

  • A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of aA dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities.show moreshow less

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Author:Claudia Haegele, Florian Schlagenhauf, Michael Armin RappORCiDGND, Philipp Sterzer, Anne Beck, Felix Bermpohl, Meline Stoy, Andreas Stroehle, Hans-Ulrich Wittchen, Raymond J. Dolan, Andreas Heinz
DOI:https://doi.org/10.1007/s00213-014-3662-7
ISSN:0033-3158 (print)
ISSN:1432-2072 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=24973896
Parent Title (English):Psychopharmacology
Publisher:Springer
Place of publication:New York
Document Type:Article
Language:English
Year of first Publication:2015
Year of Completion:2015
Release Date:2017/03/27
Tag:Depressive symptoms; Dimensional; Monetary incentive delay task; Reward system; Ventral striatum; fMRI
Volume:232
Issue:2
Pagenumber:11
First Page:331
Last Page:341
Funder:German Research Foundation (Deutsche Forschungsgemeinschaft) [HE 2597/4-3, 7-3, 15-1 (FOR1617), EXC 257, SCHL1969/1-1, 2-1, STE-1430/6-1, WI709/10-1]; Bundesministerium fur Bildung und Forschung [01GQ0411, 01KR1207C, 01GS08159]
Organizational units:Humanwissenschaftliche Fakultät / Institut für Sportmedizin und Prävention
Peer Review:Referiert