Variability of single trial brain activation predicts fluctuations in reaction time

  • Brain activation stability is crucial to understanding attention lapses. EEG methods could provide excellent markers to assess neuronal response variability with respect to temporal (intertrial coherence) and spatial variability (topographic consistency) as well as variations in activation intensity (low frequency variability of single trial global field power). We calculated intertrial coherence, topographic consistency and low frequency amplitude variability during target P300 in a continuous performance test in 263 15-year-olds from a cohort with psychosocial and biological risk factors. Topographic consistency and low frequency amplitude variability predicted reaction time fluctuations (RTSD) in a linear model. Higher RTSD was only associated with higher psychosocial adversity in the presence of the homozygous 6R-10R dopamine transporter haplotype. We propose that topographic variability of single trial P300 reflects noise as well as variability in evoked cortical activation patterns. Dopaminergic neuromodulation interactedBrain activation stability is crucial to understanding attention lapses. EEG methods could provide excellent markers to assess neuronal response variability with respect to temporal (intertrial coherence) and spatial variability (topographic consistency) as well as variations in activation intensity (low frequency variability of single trial global field power). We calculated intertrial coherence, topographic consistency and low frequency amplitude variability during target P300 in a continuous performance test in 263 15-year-olds from a cohort with psychosocial and biological risk factors. Topographic consistency and low frequency amplitude variability predicted reaction time fluctuations (RTSD) in a linear model. Higher RTSD was only associated with higher psychosocial adversity in the presence of the homozygous 6R-10R dopamine transporter haplotype. We propose that topographic variability of single trial P300 reflects noise as well as variability in evoked cortical activation patterns. Dopaminergic neuromodulation interacted with environmental and biological risk factors to predict behavioural reaction time variability. (C) 2015 Elsevier B.V. All rights reserved.show moreshow less

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Metadaten
Author:Stephan Bender, Tobias Banaschewski, Veit Rößner, Christoph Klein, Marcella Rietschel, Bernd Feige, Daniel Brandeis, Manfred Laucht
DOI:https://doi.org/10.1016/j.biopsycho.2015.01.013
ISSN:0301-0511 (print)
ISSN:1873-6246 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25643861
Parent Title (English):Biological psychology
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of first Publication:2015
Year of Completion:2015
Release Date:2017/03/27
Tag:Event related potential; Haplotype; Intertrial coherence; Low frequency amplitude variability; Psychosocial stress; Topographic consistency
Volume:106
Pagenumber:11
First Page:50
Last Page:60
Funder:German Research Foundation (DFG)
Organizational units:Humanwissenschaftliche Fakultät / Institut für Psychologie
Peer Review:Referiert