Alterations of Glucocorticoid Receptor Gene Methylation in Externalizing Disorders During Childhood and Adolescence

  • Epigenetic modulations are a hypothesized link between environmental factors and the development of psychiatric disorders. Research has suggested that patients with depression or bipolar disorder exhibit higher methylation levels in the glucocorticoid receptor gene NR3C1. We aimed to investigate whether NR3C1 methylation changes are similarly associated with externalizing disorders such as aggressive behavior and conduct disorder. NR3C1 exon 1F methylation was analyzed in young adults with a lifetime diagnosis of an externalizing disorder (N = 68) or a depressive disorder (N = 27) and healthy controls (N = 124) from the Mannheim Study of Children at Risk. The externalizing disorders group had significantly lower NR3C1 methylation levels than the lifetime depressive disorder group (p = 0.009) and healthy controls (p = 0.001) This report of lower methylation levels in NR3C1 in externalizing disorders may indicate a mechanism through which the differential development of externalizing disorders as opposed to depressive disorders mightEpigenetic modulations are a hypothesized link between environmental factors and the development of psychiatric disorders. Research has suggested that patients with depression or bipolar disorder exhibit higher methylation levels in the glucocorticoid receptor gene NR3C1. We aimed to investigate whether NR3C1 methylation changes are similarly associated with externalizing disorders such as aggressive behavior and conduct disorder. NR3C1 exon 1F methylation was analyzed in young adults with a lifetime diagnosis of an externalizing disorder (N = 68) or a depressive disorder (N = 27) and healthy controls (N = 124) from the Mannheim Study of Children at Risk. The externalizing disorders group had significantly lower NR3C1 methylation levels than the lifetime depressive disorder group (p = 0.009) and healthy controls (p = 0.001) This report of lower methylation levels in NR3C1 in externalizing disorders may indicate a mechanism through which the differential development of externalizing disorders as opposed to depressive disorders might occur.show moreshow less

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Metadaten
Author:Angela Heinrich, Arlette F. Buchmann, Katrin Zohsel, Helene Dukal, Josef Frank, Jens Treutlein, Vanessa Nieratschker, Stephanie H. Witt, Daniel Brandeis, Martin H. Schmidt, Günter EsserGND, Tobias Banaschewski, Manfred Laucht, Marcella Rietschel
DOI:https://doi.org/10.1007/s10519-015-9721-y
ISSN:0001-8244 (print)
ISSN:1573-3297 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25894927
Parent Title (English):Behavior genetics : an international journal devoted to research in the inheritance of behavior in animals and man
Publisher:Springer
Place of publication:New York
Document Type:Article
Language:English
Year of first Publication:2015
Year of Completion:2015
Release Date:2017/03/27
Tag:Adolescents; Epigenetic; Externalizing disorders; Glucocorticoid receptor; Methylation
Volume:45
Issue:5
Pagenumber:8
First Page:529
Last Page:536
Funder:German Ministry of Education and Research within National Genome Research Network plus (NGFNplus); MooDS-Net [01GS08147]; Olympia-Morata-Program of the University of Heidelberg
Organizational units:Humanwissenschaftliche Fakultät / Institut für Psychologie
Peer Review:Referiert