Synthetic multicellular oscillatory systems controlling protein dynamics with genetic circuits

  • Synthetic biology is a relatively new research discipline that combines standard biology approaches with the constructive nature of engineering. Thus, recent efforts in the field of synthetic biology have given a perspective to consider cells as 'programmable matter'. Here, we address the possibility of using synthetic circuits to control protein dynamics. In particular, we show how intercellular communication and stochasticity can be used to manipulate the dynamical behavior of a population of coupled synthetic units and, in this manner, finely tune the expression of specific proteins of interest, e.g. in large bioreactors.

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Metadaten
Author:Aneta Koseska, Evgenii Volkov, Jürgen KurthsORCiDGND
DOI:https://doi.org/10.1088/0031-8949/84/04/045007
ISSN:0031-8949 (print)
Parent Title (English):Physica scripta : an international journal for experimental and theoretical physics
Publisher:IOP Publ. Ltd.
Place of publication:Bristol
Document Type:Article
Language:English
Year of first Publication:2011
Year of Completion:2011
Release Date:2017/03/26
Volume:84
Issue:4
Pagenumber:10
Funder:Federal Ministry of Education and Research [0313924]; RFBR [11-01-00392]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie
Peer Review:Referiert