Quantitative approach to the stochastics of bone remodeling

  • During life bones constantly adapt their structure to their mechanical environment via a mechanically controlled process called bone remodeling. For trabecular bone, this process modifies the thickness of each trabecula leading occasionally to full resorption. We describe the irreversible dynamics of the trabecular thickness distribution (TTD) by means of a Markov chain discrete in space and time. By using thickness data from adult patients, we derive the transition probabilities in the chain. This allows a quantification, in terms of geometrical quantities, of the control of bone remodeling and thus to determine the evolution of the TTD with age.

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Author:Marco Rusconi, Angelo VallerianiORCiDGND, John William Chapman DunlopORCiDGND, Jürgen KurthsORCiDGND, Richard Weinkamer
ISSN:0295-5075 (print)
Parent Title (English):epl : a letters journal exploring the frontiers of physics
Publisher:EDP Sciences
Place of publication:Mulhouse
Document Type:Article
Year of first Publication:2012
Year of Completion:2012
Release Date:2017/03/26
Funder:Marie Curie "Early Stage Training on Biomimetic Systems"
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Physik und Astronomie
Peer Review:Referiert