Unprecedented, low cytotoxicity of spongelike calcium phosphate/poly(ethylene imine) hydrogel composites

  • Covalently crosslinked PEI hydrogels are efficient templates for calcium phosphate mineralization in SBF. In contrast to the PEI hydrogels, non-crosslinked PEI does not lead to calcium phosphate nucleation and growth in SBF. The precipitate is a mixture of brushite and hydroxyapatite. The PEI/calcium phosphate composite material exhibits a sponge like morphology and a chemical composition that is interesting for implants. Cytotoxicity tests using Dictyostelium discoideum amoebae show that both the non-mineralized and mineralized hydrogels have a very low cytotoxicity. This suggests that next generation PEI hydrogels, where also the degradation products are non-toxic, could be interesting for biomedical applications.

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Author:Andriy Shkilnyy, Ralph Graef, Bernhard Hiebl, Axel T. Neffe, Alwin Friedrich, Juergen Hartmann, Andreas TaubertORCiDGND
URL:http://www3.interscience.wiley.com/cgi-bin/jhome/77002860
DOI:https://doi.org/10.1002/mabi.200800266
ISSN:1616-5187
Document Type:Article
Language:English
Year of first Publication:2009
Year of Completion:2009
Release Date:2017/03/25
Source:Macromolecular bioscience. - ISSN 1616-5187. - 9 (2009), 2, S. 179 - 186
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert