TY  - JOUR
A1  - Fruscalzo, Arrigo
A1  - Frommer, Julia-Marie
A1  - Londero, Ambrogio P.
A1  - Henze, Andrea
A1  - Schweigert, Florian J.
A1  - Nofer, Jerzy-Roch
A1  - Steinhard, Johannes
A1  - Klockenbusch, Walter
A1  - Schmitz, Ralf
A1  - Raila, Jens
T1  - First trimester TTR-RBP4-ROH complex and angiogenic factors in the prediction of small for gestational age infant’s outcome
JF  - Archives of gynecology and obstetrics
N2  - To study the role of the TTR-RBP4-ROH complex components (transthyretin, serum retinol binding protein, retinol) and of angiogenic factors PlGF (placental growth factor) and sFlt-1 (soluble fms-like tyrosine kinase-1) in pregnancies complicated by small for gestational age infants (SGA). Case control study conducted on maternal serum collected between 11 + 0 to 13 + 6 weeks of gestation. TTR, RBP4, ROH, PlGF and sFlt-1 were measured in SGA patients (birth weight < 10%) who delivered at term (n = 37) and before 37 weeks of gestation (n = 17) and in a matched control group with uneventful pregnancies (n = 37). We found decreased RBP4 in SGA patients that delivered fetuses < 3% and in fetuses delivered after the 37 weeks of gestation compared to controls [1.50 (95% CI 1.40-1.75) vs 1.62 (95% CI 1.47-1.98), p < 0.05]. Further, we found lower PlGF and sFlt-1 concentrations in SGA that delivered before 37 weeks of gestation compared to controls (respectively, PIGF and sFlt-1: 39.7 pg/ml (95% CI 32.3-66.3) vs 62.9 pg/ml (95% CI 45.2-78.4) and 906 pg/ml (95% CI 727-1626) vs 1610 pg/ml (95% CI 1088-212), p < 0.05). First trimester maternal serum RBP4 and angiogenic factors PlGF and sFlt-1 can differently predict the timing of delivery of pregnancies complicated by SGA fetuses.
KW  - Low birth weight
KW  - Small for gestational age
KW  - Pregnancy
KW  - First trimester
KW  - Marker
KW  - RBP4
KW  - TTR
KW  - Retinol
KW  - Vitamin A
KW  - sFlt-1
KW  - PlGF
Y1  - 2017
U6  - https://doi.org/10.1007/s00404-017-4338-4
SN  - 0932-0067
SN  - 1432-0711
VL  - 295
SP  - 1157
EP  - 1165
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Lu, Yong-Ping
A1  - Hasan, Ahmed A.
A1  - Zeng, Shufei
A1  - Hocher, Berthold
T1  - Plasma ET-1 concentrations are elevated in pregnant women with hypertension - meta-analysis of clinical studies
JF  - Kidney & blood pressure research : official organ of the Gesellschaft für Nephrologie ; official organ of the Deutsche Liga zur Bekämpfung des Hohen Blutdruckes e.V., Deutsche Hypertonie-Gesellschaft
N2  - Background/Aims:
The ET system might be involved in the pathogenesis of hypertensive disorders during pregnancy. The objective is to analyse the impact of ET-1 in hypertensive pregnant women by a strict meta-analysis of published human clinical studies. 
Methods:
Based on the principle of Cochrane systematic reviews, Cohort studies in PubMed (Medline), Google Scholar and China Biological Medicine Database (CBM-disc) designed to identify the role of endothelin-1 (ET-1) in the pathophysiology of gestational hypertension and preeclampsia were screened. Review Manager Version 5.0 (Rev-Man 5.0) was applied for statistical analysis. Mean difference and 95% confidence interval (CI) were shown in inverse variance (IV) fixed-effects model or IV random-effects model.
Results:
Sixteen published cohort studies including 1739 hypertensive cases and 409 controls were used in the meta-analysis. ET-1 plasma concentrations were higher in hypertensive pregnant women as compared to the controls (mean difference between groups: 19.02 [15.60～22.44], P < 0.00001,). These finding were driven by severity of hypertension and/or degree of proteinuria.
Conclusion:
Plasma ET-1 concentrations are elevated in hypertensive disorders during human pregnancy. In particular women with preeclampsia (hypertensive pregnant women with proteinuria) have substantially elevated plasma ET-1 concentration as compared to pregnant women with normal blood pressure.
KW  - Et-1
KW  - Pregnancy
KW  - Hypertension
KW  - Meta-analysis
Y1  - 2017
U6  - https://doi.org/10.1159/000482004
SN  - 1420-4096
SN  - 1423-0143
VL  - 42
IS  - 4
SP  - 654
EP  - 663
PB  - Karger
CY  - Basel
ER  -