TY  - JOUR
A1  - Schmälzlin, Elmar Gerd
A1  - Moralejo, Benito
A1  - Gersonde, Ingo
A1  - Schleusener, Johannes
A1  - Darvin, Maxim E.
A1  - Thiede, Gisela
A1  - Roth, Martin M.
T1  - Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination
JF  - Journal of biomedical optics
N2  - Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.
KW  - Raman spectroscopy
KW  - cancer diagnosis
KW  - Raman imaging
KW  - multichannel
KW  - astronomy
KW  - epidermis
KW  - dermis
Y1  - 2018
U6  - https://doi.org/10.1117/1.JBO.23.10.105001
SN  - 1083-3668
SN  - 1560-2281
VL  - 23
IS  - 10
PB  - SPIE
CY  - Bellingham
ER  - 
TY  - JOUR
A1  - Sarhan, Radwan Mohamed
A1  - Koopman, Wouter-Willem Adriaan
A1  - Pudell, Jan-Etienne
A1  - Stete, Felix
A1  - Rössle, Matthias
A1  - Herzog, Marc
A1  - Schmitt, Clemens Nikolaus Zeno
A1  - Liebig, Ferenc
A1  - Koetz, Joachim
A1  - Bargheer, Matias
T1  - Scaling up nanoplasmon catalysis
BT  - the role of heat dissipation
JF  - The journal of physical chemistry : C, Nanomaterials and interfaces
N2  - Nanoscale heating by optical excitation of plasmonic nanoparticles offers a new perspective of controlling chemical reactions, where heat is not spatially uniform as in conventional macroscopic heating but strong temperature gradients exist around microscopic hot spots. In nanoplasmonics, metal particles act as a nanosource of light, heat, and energetic electrons driven by resonant excitation of their localized surface plasmon resonance. As an example of the coupling reaction of 4-nitrothiophenol into 4,4′-dimercaptoazobenzene, we show that besides the nanoscopic heat distribution at hot spots, the microscopic distribution of heat dictated by the spot size of the light focus also plays a crucial role in the design of plasmonic nanoreactors. Small sizes of laser spots enable high intensities to drive plasmon-assisted catalysis. This facilitates the observation of such reactions by surface-enhanced Raman scattering, but it challenges attempts to scale nanoplasmonic chemistry up to large areas, where the excess heat must be dissipated by one-dimensional heat transport.
KW  - Gold
KW  - Raman spectroscopy
KW  - Silicon
KW  - Irradiation
KW  - Lasers
Y1  - 2019
U6  - https://doi.org/10.1021/acs.jpcc.8b12574
SN  - 1932-7447
VL  - 123
IS  - 14
SP  - 9352
EP  - 9357
PB  - American Chemical Society
CY  - Washington
ER  -