TY  - THES
A1  - Schwarz, Michael
T1  - Nodal domains and boundary representation for Dirichlet forms
Y1  - 2020
ER  - 
TY  - JOUR
A1  - Seelig, Stefan A.
A1  - Rabe, Maximilian Michael
A1  - Malem-Shinitski, Noa
A1  - Risse, Sarah
A1  - Reich, Sebastian
A1  - Engbert, Ralf
T1  - Bayesian parameter estimation for the SWIFT model of eye-movement control during reading
JF  - Journal of mathematical psychology
N2  - Process-oriented theories of cognition must be evaluated against time-ordered observations. Here we present a representative example for data assimilation of the SWIFT model, a dynamical model of the control of fixation positions and fixation durations during natural reading of single sentences. First, we develop and test an approximate likelihood function of the model, which is a combination of a spatial, pseudo-marginal likelihood and a temporal likelihood obtained by probability density approximation Second, we implement a Bayesian approach to parameter inference using an adaptive Markov chain Monte Carlo procedure. Our results indicate that model parameters can be estimated reliably for individual subjects. We conclude that approximative Bayesian inference represents a considerable step forward for computational models of eye-movement control, where modeling of individual data on the basis of process-based dynamic models has not been possible so far.
KW  - dynamical models
KW  - reading
KW  - eye movements
KW  - saccades
KW  - likelihood function
KW  - Bayesian inference
KW  - MCMC
KW  - interindividual differences
Y1  - 2020
U6  - https://doi.org/10.1016/j.jmp.2019.102313
SN  - 0022-2496
SN  - 1096-0880
VL  - 95
PB  - Elsevier
CY  - San Diego
ER  - 
TY  - JOUR
A1  - Wiljes, Jana de
A1  - Tong, Xin T.
T1  - Analysis of a localised nonlinear ensemble Kalman Bucy filter with complete and accurate observations
JF  - Nonlinearity
N2  - Concurrent observation technologies have made high-precision real-time data available in large quantities. Data assimilation (DA) is concerned with how to combine this data with physical models to produce accurate predictions. For spatial-temporal models, the ensemble Kalman filter with proper localisation techniques is considered to be a state-of-the-art DA methodology. This article proposes and investigates a localised ensemble Kalman Bucy filter for nonlinear models with short-range interactions. We derive dimension-independent and component-wise error bounds and show the long time path-wise error only has logarithmic dependence on the time range. The theoretical results are verified through some simple numerical tests.
KW  - data assimilation
KW  - stability and accuracy
KW  - dimension independent bound
KW  - localisation
KW  - high dimensional
KW  - filter
KW  - nonlinear
Y1  - 2020
U6  - https://doi.org/10.1088/1361-6544/ab8d14
SN  - 0951-7715
SN  - 1361-6544
VL  - 33
IS  - 9
SP  - 4752
EP  - 4782
PB  - IOP Publ.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Purinton, Benjamin
A1  - Bookhagen, Bodo
T1  - Multiband (X, C, L) radar amplitude analysis for a mixed sand- and gravel-bed river in the eastern Central Andes
JF  - Remote sensing of environment : an interdisciplinary journal
N2  - Synthetic Aperture Radar (SAR) amplitude measurements from spaceborne sensors are sensitive to surface roughness conditions near their radar wavelength. These backscatter signals are often exploited to assess the roughness of plowed agricultural fields and water surfaces, and less so to complex, heterogeneous geological surfaces. The bedload of mixed sand- and gravel-bed rivers can be considered a mixture of smooth (compacted sand) and rough (gravel) surfaces. Here, we assess backscatter gradients over a large high-mountain alluvial river in the eastern Central Andes with aerially exposed sand and gravel bedload using X-band TerraSAR-X/TanDEM-X, C-band Sentinel-1, and L-band ALOS-2 PALSAR-2 radar scenes. In a first step, we present theory and hypotheses regarding radar response to an alluvial channel bed. We test our hypotheses by comparing backscatter responses over vegetation-free endmember surfaces from inside and outside of the active channel-bed area. We then develop methods to extract smoothed backscatter gradients downstream along the channel using kernel density estimates. In a final step, the local variability of sand-dominated patches is analyzed using Fourier frequency analysis, by fitting stretched-exponential and power-law regression models to the 2-D power spectrum of backscatter amplitude. We find a large range in backscatter depending on the heterogeneity of contiguous smooth- and rough-patches of bedload material. The SAR amplitude signal responds primarily to the fraction of smooth-sand bedload, but is further modified by gravel elements. The sensitivity to gravel is more apparent in longer wavelength L-band radar, whereas C- and X-band is sensitive only to sand variability. Because the spatial extent of smooth sand patches in our study area is typically< 50 m, only higher resolution sensors (e.g., TerraSAR-X/TanDEM-X) are useful for power spectrum analysis. Our results show the potential for mapping sand-gravel transitions and local geomorphic complexity in alluvial rivers with aerially exposed bedload using SAR amplitude.
KW  - SAR amplitude
KW  - Radar backscatter
KW  - Surface roughness
KW  - Fluvial
KW  - geomorphology
KW  - TerraSAR-X/TanDEM-X
KW  - Sentinel-1
KW  - ALOS-2 PALSAR-2
Y1  - 2020
U6  - https://doi.org/10.1016/j.rse.2020.111799
SN  - 0034-4257
SN  - 1879-0704
VL  - 246
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Malem-Shinitski, Noa
A1  - Opper, Manfred
A1  - Reich, Sebastian
A1  - Schwetlick, Lisa
A1  - Seelig, Stefan A.
A1  - Engbert, Ralf
T1  - A mathematical model of local and global attention in natural scene viewing
JF  - PLoS Computational Biology : a new community journal
N2  - Author summary <br /> Switching between local and global attention is a general strategy in human information processing. We investigate whether this strategy is a viable approach to model sequences of fixations generated by a human observer in a free viewing task with natural scenes. Variants of the basic model are used to predict the experimental data based on Bayesian inference. Results indicate a high predictive power for both aggregated data and individual differences across observers. The combination of a novel model with state-of-the-art Bayesian methods lends support to our two-state model using local and global internal attention states for controlling eye movements. <br /> Understanding the decision process underlying gaze control is an important question in cognitive neuroscience with applications in diverse fields ranging from psychology to computer vision. The decision for choosing an upcoming saccade target can be framed as a selection process between two states: Should the observer further inspect the information near the current gaze position (local attention) or continue with exploration of other patches of the given scene (global attention)? Here we propose and investigate a mathematical model motivated by switching between these two attentional states during scene viewing. The model is derived from a minimal set of assumptions that generates realistic eye movement behavior. We implemented a Bayesian approach for model parameter inference based on the model's likelihood function. In order to simplify the inference, we applied data augmentation methods that allowed the use of conjugate priors and the construction of an efficient Gibbs sampler. This approach turned out to be numerically efficient and permitted fitting interindividual differences in saccade statistics. Thus, the main contribution of our modeling approach is two-fold; first, we propose a new model for saccade generation in scene viewing. Second, we demonstrate the use of novel methods from Bayesian inference in the field of scan path modeling.
Y1  - 2020
U6  - https://doi.org/10.1371/journal.pcbi.1007880
SN  - 1553-734X
SN  - 1553-7358
VL  - 16
IS  - 12
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Pornsawad, Pornsarp
A1  - Sungcharoen, Parada
A1  - Böckmann, Christine
T1  - Convergence rate of the modified Landweber method for solving inverse potential problems
JF  - Mathematics : open access journal
N2  - In this paper, we present the convergence rate analysis of the modified Landweber method under logarithmic source condition for nonlinear ill-posed problems. The regularization parameter is chosen according to the discrepancy principle. The reconstructions of the shape of an unknown domain for an inverse potential problem by using the modified Landweber method are exhibited.
KW  - nonlinear operator
KW  - regularization
KW  - modified Landweber method
KW  - discrepancy principle
KW  - logarithmic source condition
Y1  - 2020
U6  - https://doi.org/10.3390/math8040608
SN  - 2227-7390
VL  - 8
IS  - 4
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - de Wiljes, Jana
A1  - Pathiraja, Sahani Darschika
A1  - Reich, Sebastian
T1  - Ensemble transform algorithms for nonlinear smoothing problems
JF  - SIAM journal on scientific computing
N2  - Several numerical tools designed to overcome the challenges of smoothing in a non-linear and non-Gaussian setting are investigated for a class of particle smoothers. The considered family of smoothers is induced by the class of linear ensemble transform filters which contains classical filters such as the stochastic ensemble Kalman filter, the ensemble square root filter, and the recently introduced nonlinear ensemble transform filter. Further the ensemble transform particle smoother is introduced and particularly highlighted as it is consistent in the particle limit and does not require assumptions with respect to the family of the posterior distribution. The linear update pattern of the considered class of linear ensemble transform smoothers allows one to implement important supplementary techniques such as adaptive spread corrections, hybrid formulations, and localization in order to facilitate their application to complex estimation problems. These additional features are derived and numerically investigated for a sequence of increasingly challenging test problems.
KW  - data assimilation
KW  - smoother
KW  - localization
KW  - optimal transport
KW  - adaptive
KW  - spread correction
Y1  - 2019
U6  - https://doi.org/10.1137/19M1239544
SN  - 1064-8275
SN  - 1095-7197
VL  - 42
IS  - 1
SP  - A87
EP  - A114
PB  - Society for Industrial and Applied Mathematics
CY  - Philadelphia
ER  - 
TY  - GEN
A1  - Kolbe, Benedikt Maximilian
A1  - Evans, Myfanwy E.
T1  - Isotopic tiling theory for hyperbolic surfaces
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - In this paper, we develop the mathematical tools needed to explore isotopy classes of tilings on hyperbolic surfaces of finite genus, possibly nonorientable, with boundary, and punctured. More specifically, we generalize results on Delaney-Dress combinatorial tiling theory using an extension of mapping class groups to orbifolds, in turn using this to study tilings of covering spaces of orbifolds. Moreover, we study finite subgroups of these mapping class groups. Our results can be used to extend the Delaney-Dress combinatorial encoding of a tiling to yield a finite symbol encoding the complexity of an isotopy class of tilings. The results of this paper provide the basis for a complete and unambiguous enumeration of isotopically distinct tilings of hyperbolic surfaces.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1347 
KW  - isotopic tiling theory
KW  - Delaney–Dress tiling theory
KW  - mapping class groups
KW  - Orbifolds
KW  - maps on surfaces
KW  - hyperbolic tilings
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-544285
SN  - 1866-8372
IS  - 1
ER  - 
TY  - BOOK
A1  - Zass, Alexander
A1  - Zagrebnov, Valentin
A1  - Sukiasyan, Hayk
A1  - Melkonyan, Tatev
A1  - Rafler, Mathias
A1  - Poghosyan, Suren
A1  - Zessin, Hans
A1  - Piatnitski, Andrey
A1  - Zhizhina, Elena
A1  - Pechersky, Eugeny
A1  - Pirogov, Sergei
A1  - Yambartsev, Anatoly
A1  - Mazzonetto, Sara
A1  - Lykov, Alexander
A1  - Malyshev, Vadim
A1  - Khachatryan, Linda
A1  - Nahapetian, Boris
A1  - Jursenas, Rytis
A1  - Jansen, Sabine
A1  - Tsagkarogiannis, Dimitrios
A1  - Kuna, Tobias
A1  - Kolesnikov, Leonid
A1  - Hryniv, Ostap
A1  - Wallace, Clare
A1  - Houdebert, Pierre
A1  - Figari, Rodolfo
A1  - Teta, Alessandro
A1  - Boldrighini, Carlo
A1  - Frigio, Sandro
A1  - Maponi, Pierluigi
A1  - Pellegrinotti, Alessandro
A1  - Sinai, Yakov G.
ED  - Roelly, Sylvie
ED  - Rafler, Mathias
ED  - Poghosyan, Suren
T1  - Proceedings of the XI international conference stochastic and analytic methods in mathematical physics
N2  - The XI international conference Stochastic and Analytic Methods in Mathematical Physics was held in Yerevan 2 – 7 September 2019 and was dedicated to the memory of the great mathematician Robert Adol’fovich Minlos, who passed away in January 2018.
The present volume collects a large majority of the contributions presented at the conference on the following domains of contemporary interest: classical and quantum statistical physics, mathematical methods in quantum mechanics, stochastic analysis, applications of point processes in statistical mechanics. The authors are specialists from Armenia, Czech Republic, Denmark, France, Germany, Italy, Japan, Lithuania, Russia, UK and Uzbekistan.
A particular aim of this volume is to offer young scientists basic material in order to inspire their future research in the wide fields presented here.
T3  - Lectures in pure and applied mathematics - 6 
KW  - statistical mechanics
KW  - random point processes
KW  - stochastic analysis
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-459192
SN  - 978-3-86956-485-2
SN  - 2199-4951
SN  - 2199-496X
IS  - 6
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - GEN
A1  - Mazzonetto, Sara
A1  - Salimova, Diyora
T1  - Existence, uniqueness, and numerical approximations for stochastic burgers equations
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - In this article, we propose an all-in-one statement which includes existence, uniqueness, regularity, and numerical approximations of mild solutions for a class of stochastic partial differential equations (SPDEs) with non-globally monotone nonlinearities. The proof of this result exploits the properties of an existing fully explicit space-time discrete approximation scheme, in particular the fact that it satisfies suitable a priori estimates. We also obtain almost sure and strong convergence of the approximation scheme to the mild solutions of the considered SPDEs. We conclude by applying the main result of the article to the stochastic Burgers equations with additive space-time white noise.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1393 
KW  - stochastic Burgers equations
KW  - SPDEs
KW  - mild solution
KW  - existence
KW  - numerical approximation
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-515796
SN  - 1866-8372
IS  - 4
ER  - 
TY  - GEN
A1  - Keller, Matthias
A1  - Pinchover, Yehuda
A1  - Pogorzelski, Felix
T1  - From hardy to rellich inequalities on graphs
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - We show how to deduce Rellich inequalities from Hardy inequalities on infinite graphs. Specifically, the obtained Rellich inequality gives an upper bound on a function by the Laplacian of the function in terms of weighted norms. These weights involve the Hardy weight and a function which satisfies an eikonal inequality. The results are proven first for Laplacians and are extended to Schrodinger operators afterwards.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1379 
KW  - 35R02
KW  - 39A12 (primary)
KW  - 26D15
KW  - 31C20
KW  - 35B09
KW  - 58E35 (secondary)
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-542140
SN  - 1866-8372
IS  - 3
ER  - 
TY  - JOUR
A1  - Kürschner, Patrick
A1  - Freitag, Melina A.
T1  - Inexact methods for the low rank solution to large scale Lyapunov equations
JF  - BIT : numerical mathematics ; the leading applied mathematics journal for all computational mathematicians
N2  - The rational Krylov subspace method (RKSM) and the low-rank alternating directions implicit (LR-ADI) iteration are established numerical tools for computing low-rank solution factors of large-scale Lyapunov equations. In order to generate the basis vectors for the RKSM, or extend the low-rank factors within the LR-ADI method, the repeated solution to a shifted linear system of equations is necessary. For very large systems this solve is usually implemented using iterative methods, leading to inexact solves within this inner iteration (and therefore to "inexact methods"). We will show that one can terminate this inner iteration before full precision has been reached and still obtain very good accuracy in the final solution to the Lyapunov equation. In particular, for both the RKSM and the LR-ADI method we derive theory for a relaxation strategy (e.g. increasing the solve tolerance of the inner iteration, as the outer iteration proceeds) within the iterative methods for solving the large linear systems. These theoretical choices involve unknown quantities, therefore practical criteria for relaxing the solution tolerance within the inner linear system are then provided. The theory is supported by several numerical examples, which show that the total amount of work for solving Lyapunov equations can be reduced significantly.
KW  - Lyapunov equation
KW  - alternating direction implicit
KW  - rational Krylov
KW  - subspaces
KW  - low-rank approximations
Y1  - 2019
U6  - https://doi.org/10.1007/s10543-020-00813-4
SN  - 0006-3835
SN  - 1572-9125
VL  - 60
IS  - 4
SP  - 1221
EP  - 1259
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Flad, Heinz-Jürgen
A1  - Flad-Harutyunyan, Gohar
A1  - Schulze, Bert-Wolfgang
T1  - Explicit Green operators for quantum mechanical Hamiltonians
BT  - II. edge-type singularities of the helium atom
JF  - Asian-European journal of mathematics : AEJM
N2  - We extend our approach of asymptotic parametrix construction for Hamiltonian operators from conical to edge-type singularities which is applicable to coalescence points of two particles of the helium atom and related two electron systems including the hydrogen molecule. Up to second-order, we have calculated the symbols of an asymptotic parametrix of the nonrelativistic Hamiltonian of the helium atom within the Born-Oppenheimer approximation and provide explicit formulas for the corresponding Green operators which encode the asymptotic behavior of the eigenfunctions near an edge.
KW  - Singular analysis
KW  - Schrodinger equation
KW  - many-electron systems
KW  - asymptotic properties of eigenfunctions
Y1  - 2020
U6  - https://doi.org/10.1142/S1793557120501223
SN  - 1793-5571
SN  - 1793-7183
VL  - 13
IS  - 7
PB  - World Scientific
CY  - Singapore
ER  - 
TY  - CHAP
A1  - Rungrottheera, Wannarut
A1  - Chang, Der-Chen
A1  - Schulze, Bert-Wolfgang
T1  - The edge calculus of singularity order >3
T2  - Journal of nonlinear and convex analysis : an international journal
N2  - We study Mellin pseudo-differential algebras on singular straight cones and manifolds with singularity of order >= 3. Those are necessary to express parametrices of elliptic differential operators with a corresponding cornerdegenerate behavior, and we obtain regularity in weighted spaces.
KW  - Pseudo-differential algebras
KW  - symbols
KW  - singular manifolds
KW  - Mellin
KW  - operator calculus
Y1  - 2020
SN  - 1345-4773
SN  - 1880-5221
VL  - 21
IS  - 2
SP  - 387
EP  - 401
PB  - Yokohama Publishers
CY  - Yokohama
ER  - 
TY  - JOUR
A1  - Zöller, Gert
A1  - Hainzl, Sebastian
A1  - Tilmann, Frederik
A1  - Woith, Heiko
A1  - Dahm, Torsten
T1  - Comment on: Wikelski, Martin; Müller, Uschi; Scocco, Paola; Catorci, Andrea; Desinov, Lev V.; Belyaev, Mikhail Y.; Keim, Daniel A.; Pohlmeier, Winfried; Fechteler, Gerhard; Mai, Martin P. : Potential short-term earthquake forecasting by farm animal monitoring. - Ethology. - 126 (2020), 9. - S. 931 - 941. -ISSN 0179-1613. - eISSN 1439-0310. - doi 10.1111/eth.13078
JF  - Ethology
N2  - Based on an analysis of continuous monitoring of farm animal behavior in the region of the 2016 M6.6 Norcia earthquake in Italy, Wikelski et al., 2020; (Seismol Res Lett, 89, 2020, 1238) conclude that animal activity can be anticipated with subsequent seismic activity and that this finding might help to design a "short-term earthquake forecasting method." We show that this result is based on an incomplete analysis and misleading interpretations. Applying state-of-the-art methods of statistics, we demonstrate that the proposed anticipatory patterns cannot be distinguished from random patterns, and consequently, the observed anomalies in animal activity do not have any forecasting power.
KW  - animal behavior
KW  - earthquake precursor
KW  - error diagram
KW  - prediction
KW  - randomness
KW  - statistics
Y1  - 2020
U6  - https://doi.org/10.1111/eth.13105
SN  - 0179-1613
SN  - 1439-0310
VL  - 127
IS  - 3
SP  - 302
EP  - 306
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Mueller-Schoell, Anna
A1  - Groenland, Stefanie L.
A1  - Scherf-Clavel, Oliver
A1  - van Dyk, Madele
A1  - Huisinga, Wilhelm
A1  - Michelet, Robin
A1  - Jaehde, Ulrich
A1  - Steeghs, Neeltje
A1  - Huitema, Alwin D. R.
A1  - Kloft, Charlotte
T1  - Therapeutic drug monitoring of oral targeted antineoplastic drugs
JF  - European journal of clinical pharmacology
N2  - Purpose This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM). Factors influencing the pharmacokinetic exposure in OAD therapy are depicted together with an overview of different TDM approaches. Finally, current evidence for TDM for all approved OADs is reviewed. Methods A comprehensive literature search (covering literature published until April 2020), including primary and secondary scientific literature on pharmacokinetics and dose individualisation strategies for OADs, together with US FDA Clinical Pharmacology and Biopharmaceutics Reviews and the Committee for Medicinal Products for Human Use European Public Assessment Reports was conducted. Results OADs are highly potent drugs, which have substantially changed treatment options for cancer patients. Nevertheless, high pharmacokinetic variability and low treatment adherence are risk factors for treatment failure. TDM is a powerful tool to individualise drug dosing, ensure drug concentrations within the therapeutic window and increase treatment success rates. After reviewing the literature for 71 approved OADs, we show that exposure-response and/or exposure-toxicity relationships have been established for the majority. Moreover, TDM has been proven to be feasible for individualised dosing of abiraterone, everolimus, imatinib, pazopanib, sunitinib and tamoxifen in prospective studies. There is a lack of experience in how to best implement TDM as part of clinical routine in OAD cancer therapy. Conclusion Sub-therapeutic concentrations and severe adverse events are current challenges in OAD treatment, which can both be addressed by the application of TDM-guided dosing, ensuring concentrations within the therapeutic window.
KW  - targeted antineoplastic drugs
KW  - tyrosine kinase inhibitors
KW  - therapeutic
KW  - drug monitoring
KW  - oral anticancer drugs
KW  - personalised medicine
Y1  - 2020
U6  - https://doi.org/10.1007/s00228-020-03014-8
SN  - 0031-6970
SN  - 1432-1041
VL  - 77
IS  - 4
SP  - 441
EP  - 464
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - JOUR
A1  - Grisic, Ana-Marija
A1  - Eser, Alexander
A1  - Huisinga, Wilhelm
A1  - Reinisch, Walter
A1  - Kloft, Charlotte
T1  - Quantitative relationship between infliximab exposure and inhibition of C-reactive protein synthesis to support inflammatory bowel disease management
JF  - British journal of clinical pharmacology
N2  - Aim Quantitative and kinetic insights into the drug exposure-disease response relationship might enhance our knowledge on loss of response and support more effective monitoring of inflammatory activity by biomarkers in patients with inflammatory bowel disease (IBD) treated with infliximab (IFX). This study aimed to derive recommendations for dose adjustment and treatment optimisation based on mechanistic characterisation of the relationship between IFX serum concentration and C-reactive protein (CRP) concentration. <br /> Methods Data from an investigator-initiated trial included 121 patients with IBD during IFX maintenance treatment. Serum concentrations of IFX, antidrug antibodies (ADA), CRP, and disease-related covariates were determined at the mid-term and end of a dosing interval. Data were analysed using a pharmacometric nonlinear mixed-effects modelling approach. An IFX exposure-CRP model was generated and applied to evaluate dosing regimens to achieve CRP remission. <br /> Results The generated quantitative model showed that IFX has the potential to inhibit up to 72% (9% relative standard error [RSE]) of CRP synthesis in a patient. IFX concentration leading to 90% of the maximum CRP synthesis inhibition was 18.4 mu g/mL (43% RSE). Presence of ADA was the most influential factor on IFX exposure. With standard dosing strategy, >= 55% of ADA+ patients experienced CRP nonremission. Shortening the dosing interval and co-therapy with immunomodulators were found to be the most beneficial strategies to maintain CRP remission. <br /> Conclusions With the generated model we could for the first time establish a robust relationship between IFX exposure and CRP synthesis inhibition, which could be utilised for treatment optimisation in IBD patients.
KW  - C‐ reactive protein remission
KW  - inflammatory bowel disease
KW  - infliximab dosing
Y1  - 2020
U6  - https://doi.org/10.1111/bcp.14648
SN  - 0306-5251
SN  - 1365-2125
VL  - 87
IS  - 5
SP  - 2374
EP  - 2384
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Kluwe, Franziska
A1  - Michelet, Robin
A1  - Müller-Schöll, Anna
A1  - Maier, Corinna
A1  - Klopp-Schulze, Lena
A1  - van Dyk, Madele
A1  - Mikus, Gerd
A1  - Huisinga, Wilhelm
A1  - Kloft, Charlotte
T1  - Perspectives on model-informed precision dosing in the digital health era
BT  - challenges, opportunities, and recommendations
JF  - Clinical pharmacology & therapeutics
Y1  - 2020
U6  - https://doi.org/10.1002/cpt.2049
SN  - 0009-9236
SN  - 1532-6535
VL  - 109
IS  - 1
SP  - 29
EP  - 36
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Sharma, Shubham
A1  - Hainzl, Sebastian
A1  - Zöller, Gert
A1  - Holschneider, Matthias
T1  - Is Coulomb stress the best choice for aftershock forecasting?
JF  - Journal of geophysical research : Solid earth
N2  - The Coulomb failure stress (CFS) criterion is the most commonly used method for predicting spatial distributions of aftershocks following large earthquakes. However, large uncertainties are always associated with the calculation of Coulomb stress change. The uncertainties mainly arise due to nonunique slip inversions and unknown receiver faults; especially for the latter, results are highly dependent on the choice of the assumed receiver mechanism. Based on binary tests (aftershocks yes/no), recent studies suggest that alternative stress quantities, a distance-slip probabilistic model as well as deep neural network (DNN) approaches, all are superior to CFS with predefined receiver mechanism. To challenge this conclusion, which might have large implications, we use 289 slip inversions from SRCMOD database to calculate more realistic CFS values for a layered half-space and variable receiver mechanisms. We also analyze the effect of the magnitude cutoff, grid size variation, and aftershock duration to verify the use of receiver operating characteristic (ROC) analysis for the ranking of stress metrics. The observations suggest that introducing a layered half-space does not improve the stress maps and ROC curves. However, results significantly improve for larger aftershocks and shorter time periods but without changing the ranking. We also go beyond binary testing and apply alternative statistics to test the ability to estimate aftershock numbers, which confirm that simple stress metrics perform better than the classic Coulomb failure stress calculations and are also better than the distance-slip probabilistic model.
Y1  - 2020
U6  - https://doi.org/10.1029/2020JB019553
SN  - 2169-9313
SN  - 2169-9356
VL  - 125
IS  - 9
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Dimitrova, Ilinka
A1  - Koppitz, Jörg
T1  - On relative ranks of the semigroup of orientation-preserving transformations on infinite chains
JF  - Asian-European journal of mathematics
N2  - In this paper, we determine the relative rank of the semigroup OP(X) of all orientation-preserving transformations on infinite chains modulo the semigroup O(X) of all order-preserving transformations.
KW  - Transformation semigroups on infinite chains
KW  - order-preserving
KW  - transformations
KW  - orientation-preserving transformations
KW  - relative rank
Y1  - 2020
U6  - https://doi.org/10.1142/S1793557121501461
SN  - 1793-5571
SN  - 1793-7183
VL  - 14
IS  - 08
PB  - World Scientific
CY  - Singapore
ER  -