TY  - JOUR
A1  - Batsios, Petros
A1  - Gräf, Ralph
A1  - Koonce, Michael P.
A1  - Larochelle, Denis A.
A1  - Meyer, Irene
T1  - Nuclear envelope organization in Dictyostelium discoideum
JF  - The international journal of developmental biology
N2  - The nuclear envelope consists of the outer and the inner nuclear membrane, the nuclear lamina and the nuclear pore complexes, which regulate nuclear import and export.The major constituent of the nuclear lamina of Dictyostelium is the lamin NE81. It can form filaments like B-type lamins and it interacts with Sun 1, as well as with the LEM/HeH-family protein Src1. Sun 1 and Src1 are nuclear envelope transmembrane proteins involved in the centrosome-nucleus connection and nuclear envelope stability at the nucleolar regions, respectively. In conjunction with a KASH-domain protein, Sun 1 usually forms a so-called LINC complex.Two proteins with functions reminiscent of KASH-domain proteins at the outer nuclear membrane of Dictyostelium are known; interaptin which serves as an actin connector and the kinesin Kif9 which plays a role in the microtubule-centrosome connector. However, both of these lack the conserved KASH-domain. The link of the centrosome to the nuclear envelope is essential for the insertion of the centrosome into the nuclear envelope and the appropriate spindle formation. Moreover, centrosome insertion is involved in perm eabilization of the mitotic nucleus, which ensures access of tubulin dimers and spindle assembly factors. Our recent progress in identifying key molecular players at the nuclear envelope of Dictyostelium promises further insights into the mechanisms of nuclear envelope dynamics.
KW  - nuclear envelop
KW  - Dictyostelium
KW  - lamin
KW  - NET
KW  - centrosome
KW  - centromere
Y1  - 2019
U6  - https://doi.org/10.1387/ijdb.190184rg
SN  - 0214-6282
SN  - 1696-3547
VL  - 63
IS  - 8-10
SP  - 509
EP  - 519
PB  - UBC Pr
CY  - Bilbao
ER  -