TY  - JOUR
A1  - Bornhorst, Julia
A1  - Kipp, Anna Patricia
A1  - Haase, Hajo
A1  - Meyer, Soeren
A1  - Schwerdtle, Tanja
T1  - The crux of inept biomarkers for risks and benefits of trace elements
JF  - Trends in Analytical Chemistry
N2  - Nowadays, the role of trace elements (TE) is of growing interest because dyshomeostasis of selenium (Se), manganese (Mn), zinc (Zn), and copper (Cu) is supposed to be a risk factor for several diseases. Thereby, research focuses on identifying new biomarkers for the TE status to allow for a more reliable description of the individual TE and health status. This review mirrors a lack of well-defined, sensitive, and selective biomarkers and summarizes technical limitations to measure them. Thus, the capacity to assess the relationship between dietary TE intake, homeostasis, and health is restricted, which would otherwise provide the basis to define adequate intake levels of single TE in both healthy and diseased humans. Besides that, our knowledge is even more limited with respect to the real life situation of combined TE intake and putative interactions between single TE.
KW  - Trace elements
KW  - Copper
KW  - Zinc
KW  - Manganese
KW  - Selenium
KW  - Biomarker
KW  - Inductively coupled plasma mass spectrometry
KW  - Hyphenated techniques
KW  - Isotope ratios
Y1  - 2018
U6  - https://doi.org/10.1016/j.trac.2017.11.007
SN  - 0165-9936
SN  - 1879-3142
VL  - 104
SP  - 183
EP  - 190
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Fischer, Eric Wolfgang
A1  - Saalfrank, Peter
T1  - A thermofield-based multilayer multiconfigurational time-dependent Hartree approach to non-adiabatic quantum dynamics at finite temperature
JF  - The journal of chemical physics : bridges a gap between journals of physics and journals of chemistry
N2  - We introduce a thermofield-based formulation of the multilayer multiconfigurational time-dependent Hartree (MCTDH) method to study finite temperature effects on non-adiabatic quantum dynamics from a non-stochastic, wave function perspective. Our approach is based on the formal equivalence of bosonic many-body theory at zero temperature with a doubled number of degrees of freedom and the thermal quasi-particle representation of bosonic thermofield dynamics (TFD). This equivalence allows for a transfer of bosonic many-body MCTDH as introduced by Wang and Thoss to the finite temperature framework of thermal quasi-particle TFD. As an application, we study temperature effects on the ultrafast internal conversion dynamics in pyrazine. We show that finite temperature effects can be efficiently accounted for in the construction of multilayer expansions of thermofield states in the framework presented herein. Furthermore, we find our results to agree well with existing studies on the pyrazine model based on the pMCTDH method.
Y1  - 2021
U6  - https://doi.org/10.1063/5.0064013
SN  - 0021-9606
SN  - 1089-7690
VL  - 155
IS  - 13
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - CHAP
A1  - Wang, Zhenyu
A1  - Breternitz, Joachim
A1  - Schorr, Susan
T1  - Cation disorder in zinc-group IV- nitride and oxide nitride semiconductor materials revealed through neutron diffraction
T2  - Acta crystallographica / International Union of Crystallography. Section A, Foundations and advances
KW  - nitride materials
KW  - semiconductors
KW  - structure-property relationships
Y1  - 2021
U6  - https://doi.org/10.1107/S0108767321086256
SN  - 2053-2733
VL  - 77
IS  - Suppl.
SP  - C1077
EP  - C1077
PB  - Blackwell
CY  - Oxford [u.a.]
ER  - 
TY  - JOUR
A1  - Dambacher, Michael
A1  - Kliegl, Reinhold
A1  - Hofmann, Markus
A1  - Jacobs, Arthur M.
T1  - Frequency and predictability effects on event-related potentials during reading
N2  - Effects of frequency, predictability, and position of words on event-related potentials were assessed during word-by-word sentence reading in 48 subjects in an early and in a late time window corresponding to P200 and N400. Repeated measures multiple regression analyses revealed a P200 effect in the high-frequency range also the P200 was larger on words at the beginning and end of sentences than on words in the middle of sentences (i.e., a quadratic effect of word position). Predictability strongly affected the N400 component; the effect was stronger for low than for high- frequency words. The P200 frequency effect indicates that high-frequency words are lexically accessed very fast, independent of context information. Effects on the N400 suggest that predictability strongly moderates the late access especially of low-frequency words. Thus, contextual facilitation on the N400 appears to reflect both lexical and post- lexical stages of word recognition, questioning a strict classification into lexical and post-lexical processes.
Y1  - 2006
UR  - http://www.sciencedirect.com/science/journal/00068993
U6  - https://doi.org/10.1016/j.brainres.2006.02.010
SN  - 0006-8993
ER  - 
TY  - JOUR
A1  - Göttlich, Richard
A1  - Graulich, Nicole
A1  - Huwer, Johannes
A1  - Banerji, Amitabh
T1  - Analog und digital
BT  - Chemieunterricht mit Potenzial
JF  - Chemie konkret : CHEMKON ; Forum für Unterricht und Didaktik
Y1  - 2022
U6  - https://doi.org/10.1002/ckon.202200046
SN  - 0944-5846
SN  - 1521-3730
VL  - 29
SP  - 182
EP  - 182
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Piekarczyk, Andreas
A1  - Heitmann, Ulrike
A1  - Weiß, Karl-Anders
A1  - Köhl, Michael
A1  - Bald, Ilko
T1  - Development of a simple setup for temperature dependent mass spectrometric measurements for the investigation of outgassing effects in polymeric materials for solar application
JF  - Polymer testing
N2  - A simple experimental setup for temperature dependent mass spectrometric measurements has been constructed. It consists of a heated sample chamber and a mass spectrometer and allows for measurements under inert gas and ambient air. Based on initial measurements on two extruded polystyrene (XPS) samples a methodology for the data analysis has been developed. With this methodology the outgassing temperature of volatile compounds, which were used as blowing agents, has been identified. Furthermore, the composition of the blowing agents has been analyzed by temperature dependent mass spectra. The results indicate the use of ambient air in one material and a mixture of the banned blowing agents R142b and R22, both hydrochlorofluorocarbons (HCFC), in the other material. The here described methodology provides an easy to use approach to identify such compounds, for example as part of environmental or quality control.
Y1  - 2019
U6  - https://doi.org/10.1016/j.polymertesting.2019.106164
SN  - 0142-9418
SN  - 1873-2348
VL  - 81
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Liebig, Ferenc
A1  - Sarhan, Radwan Mohamed
A1  - Schmitt, Clemens Nikolaus Zeno
A1  - Thünemann, Andreas F.
A1  - Prietzel, Claudia Christina
A1  - Bargheer, Matias
A1  - Koetz, Joachim
T1  - Gold nanotriangles with crumble topping and their influence on catalysis and surface-enhanced raman spectroscopy
JF  - ChemPlusChem
N2  - By adding hyaluronic acid (HA) to dioctyl sodium sulfosuccinate (AOT)-stabilized gold nanotriangles (AuNTs) with an average thickness of 7.5 +/- 1 nm and an edge length of about 175 +/- 17 nm, the AOT bilayer is replaced by a polymeric HA-layer leading to biocompatible nanoplatelets. The subsequent reduction process of tetrachloroauric acid in the HA-shell surrounding the AuNTs leads to the formation of spherical gold nanoparticles on the platelet surface. With increasing tetrachloroauric acid concentration, the decoration with gold nanoparticles can be tuned. SAXS measurements reveal an increase of the platelet thickness up to around 14.5 nm, twice the initial value of bare AuNTs. HRTEM micrographs show welding phenomena between densely packed particles on the platelet surface, leading to a crumble formation while preserving the original crystal structure. Crumbles crystallized on top of the platelets enhance the Raman signal by a factor of around 20, and intensify the plasmon-driven dimerization of 4-nitrothiophenol (4-NTP) to 4,4 '-dimercaptoazobenzene in a yield of up to 50 %. The resulting crumbled nanotriangles, with a biopolymer shell and the absorption maximum in the second window for in vivo imaging, are promising candidates for biomedical sensing.
KW  - gold nanostructures
KW  - HRTEM
KW  - hyaluronic acid
KW  - monolayer formation
KW  - SERS
Y1  - 2020
U6  - https://doi.org/10.1002/cplu.201900745
SN  - 2192-6506
VL  - 85
IS  - 3
SP  - 519
EP  - 526
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Deng, Zijun
A1  - Wang, Weiwei
A1  - Xua, Xun
A1  - Gould, Oliver E. C.
A1  - Kratz, Karl
A1  - Ma, Nan
A1  - Lendlein, Andreas
T1  - Polymeric sheet actuators with programmable bioinstructivity
JF  - PNAS
N2  - Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.
KW  - reversible shape-memory actuator
KW  - mesenchymal stem cells
KW  - calcium influx
KW  - HDAC1
KW  - RUNX2
Y1  - 2020
U6  - https://doi.org/10.1073/pnas.1910668117
SN  - 1091-6490
VL  - 117
IS  - 4
SP  - 1895
EP  - 1901
PB  - National Academy of Sciences
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Ebel, Kenny
A1  - Bald, Ilko
T1  - Low-energy (5-20 eV) electron-induced single and double strand breaks in well-defined DNA sequences
JF  - Journal of physical chemistry letters
N2  - Ionizing radiation is used in cancer radiation therapy to effectively damage the DNA of tumors. The main damage is due to generation of highly reactive secondary species such as low-energy electrons (LEEs). The accurate quantification of DNA radiation damage of well-defined DNA target sequences in terms of absolute cross sections for LEE-induced DNA strand breaks is possible by the DNA origami technique; however, to date, it is possible only for DNA single strands. In the present work DNA double strand breaks in the DNA sequence 5 '-d(CAC)4/5 ' d(GTG)4 are compared with DNA single strand breaks in the oligonucleotides 5 '-d(CAC)4 and 5 '-d(GTG)4 upon irradiation with LEEs in the energy range from 5 to 20 eV. A maximum of strand break cross section was found around 7 and 10 eV independent of the DNA sequence, indicating that dissociative electron attachment is the underlying mechanism of strand breakage and confirming previous studies using plasmid DNA.
Y1  - 2022
U6  - https://doi.org/10.1021/acs.jpclett.2c00684
SN  - 1948-7185
VL  - 13
IS  - 22
SP  - 4871
EP  - 4876
PB  - American Chemical Society
CY  - Washington, DC
ER  - 
TY  - JOUR
A1  - Uhlemann, Erhard
A1  - Banße, Wolfgang
A1  - Ludwig, Eberhard
A1  - Schilde, Uwe
A1  - Weller, Frank
A1  - Lehmann, Andreas
T1  - Ligandenaustauschreaktionen von Bis(acetylacetonato)dioxo-molybdän(VI). Kristallstrukturen von Salicyl- aldehyd-benzoylhydrazonato(2-)]dioxom ethanol-molybdän(VI) und [Benzoylacetonbenzoylhydrazonato(2)]dioxo- triphenylphosphan-oxidmolybdän(VI)
Y1  - 1995
ER  -