TY  - JOUR
A1  - Beerenwinkel, Niko
A1  - Sing, Tobias
A1  - Lengauer, Thomas
A1  - Rahnenfuhrer, Joerg
A1  - Roomp, Kirsten
A1  - Savenkov, Igor
A1  - Fischer, Roman
A1  - Hoffmann, Daniel
A1  - Selbig, Joachim
A1  - Korn, Klaus
A1  - Walter, Hauke
A1  - Berg, Thomas
A1  - Braun, Patrick
A1  - Faetkenheuer, Gerd
A1  - Oette, Mark
A1  - Rockstroh, Juergen
A1  - Kupfer, Bernd
A1  - Kaiser, Rolf
A1  - Daeumer, Martin
T1  - Computational methods for the design of effective therapies against drug resistant HIV strains
N2  - The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted by the human immune system and by combination drug therapy. We have developed several computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genomic data
Y1  - 2005
ER  - 
TY  - JOUR
A1  - Cordes, Frank
A1  - Kaiser, Rolf
A1  - Selbig, Joachim
T1  - Bioinformatics approach to predicting HIV drug resistance
N2  - The emergence of drug resistance remains one of the most challenging issues in the treatment of HIV-1 infection. The extreme replication dynamics of HIV facilitates its escape from the selective pressure exerted by the human immune system and by the applied combination drug therapy. This article reviews computational methods whose combined use can support the design of optimal antiretroviral therapies based on viral genotypic and phenotypic data. Genotypic assays are based on the analysis of mutations associated with reduced drug susceptibility, but are difficult to interpret due to the numerous mutations and mutational patterns that confer drug resistance. Phenotypic resistance or susceptibility can be experimentally evaluated by measuring the inhibition of the viral replication in cell culture assays. However, this procedure is expensive and time consuming
Y1  - 2006
UR  - http://www.expert-reviews.com/loi/erm
U6  - https://doi.org/10.1586/14737159.6.2.207
SN  - 1473-7159
ER  -