TY  - JOUR
A1  - Gebser, Martin
A1  - Schaub, Torsten H.
A1  - Thiele, Sven
A1  - Veber, Philippe
T1  - Detecting inconsistencies in large biological networks with answer set programming
JF  - Theory and practice of logic programming
N2  - We introduce an approach to detecting inconsistencies in large biological networks by using answer set programming. To this end, we build upon a recently proposed notion of consistency between biochemical/genetic reactions and high-throughput profiles of cell activity. We then present an approach based on answer set programming to check the consistency of large-scale data sets. Moreover, we extend this methodology to provide explanations for inconsistencies by determining minimal representations of conflicts. In practice, this can be used to identify unreliable data or to indicate missing reactions.
KW  - answer set programming
KW  - bioinformatics
KW  - consistency
KW  - diagnosis
Y1  - 2011
U6  - https://doi.org/10.1017/S1471068410000554
SN  - 1471-0684
VL  - 11
IS  - 5-6
SP  - 323
EP  - 360
PB  - Cambridge Univ. Press
CY  - New York
ER  -