TY - JOUR A1 - Fandiño, Jorge A1 - Lifschitz, Vladimir A1 - Lühne, Patrick A1 - Schaub, Torsten T1 - Verifying tight logic programs with Anthem and Vampire JF - Theory and practice of logic programming N2 - This paper continues the line of research aimed at investigating the relationship between logic programs and first-order theories. We extend the definition of program completion to programs with input and output in a subset of the input language of the ASP grounder gringo, study the relationship between stable models and completion in this context, and describe preliminary experiments with the use of two software tools, anthem and vampire, for verifying the correctness of programs with input and output. Proofs of theorems are based on a lemma that relates the semantics of programs studied in this paper to stable models of first-order formulas. Y1 - 2020 U6 - https://doi.org/10.1017/S1471068420000344 SN - 1471-0684 SN - 1475-3081 VL - 20 IS - 5 SP - 735 EP - 750 PB - Cambridge Univ. Press CY - Cambridge [u.a.] ER - TY - JOUR A1 - Kuentzer, Felipe A. A1 - Krstić, Miloš T1 - Soft error detection and correction architecture for asynchronous bundled data designs JF - IEEE transactions on circuits and systems N2 - In this paper, an asynchronous design for soft error detection and correction in combinational and sequential circuits is presented. The proposed architecture is called Asynchronous Full Error Detection and Correction (AFEDC). A custom design flow with integrated commercial EDA tools generates the AFEDC using the asynchronous bundled-data design style. The AFEDC relies on an Error Detection Circuit (EDC) for protecting the combinational logic and fault-tolerant latches for protecting the sequential logic. The EDC can be implemented using different detection methods. For this work, two boundary variants are considered, the Full Duplication with Comparison (FDC) and the Partial Duplication with Parity Prediction (PDPP). The AFEDC architecture can handle single events and timing faults of arbitrarily long duration as well as the synchronous FEDC, but additionally can address known metastability issues of the FEDC and other similar synchronous architectures and provide a more practical solution for handling the error recovery process. Two case studies are developed, a carry look-ahead adder and a pipelined non-restoring array divider. Results show that the AFEDC provides equivalent fault coverage when compared to the FEDC while reducing area, ranging from 9.6% to 17.6%, and increasing energy efficiency, which can be up to 6.5%. KW - circuit Faults KW - latches KW - Fault tolerance KW - Fault tolerant systems KW - timing KW - clocks KW - transient analysis KW - asynchrounous design KW - soft errors KW - transient Faults KW - bundled data KW - click controller KW - self-checking KW - concurrent checking KW - DMR KW - TMR Y1 - 2020 U6 - https://doi.org/10.1109/TCSI.2020.2998911 SN - 1549-8328 SN - 1558-0806 VL - 67 IS - 12 SP - 4883 EP - 4894 PB - Institute of Electrical and Electronics Engineers CY - New York ER - TY - JOUR A1 - Bordihn, Henning A1 - Vaszil, György T1 - Reversible parallel communicating finite automata systems JF - Acta informatica N2 - We study the concept of reversibility in connection with parallel communicating systems of finite automata (PCFA in short). We define the notion of reversibility in the case of PCFA (also covering the non-deterministic case) and discuss the relationship of the reversibility of the systems and the reversibility of its components. We show that a system can be reversible with non-reversible components, and the other way around, the reversibility of the components does not necessarily imply the reversibility of the system as a whole. We also investigate the computational power of deterministic centralized reversible PCFA. We show that these very simple types of PCFA (returning or non-returning) can recognize regular languages which cannot be accepted by reversible (deterministic) finite automata, and that they can even accept languages that are not context-free. We also separate the deterministic and non-deterministic variants in the case of systems with non-returning communication. We show that there are languages accepted by non-deterministic centralized PCFA, which cannot be recognized by any deterministic variant of the same type. KW - Finite automata KW - Reversibility KW - Systems of parallel communicating KW - automata Y1 - 2021 U6 - https://doi.org/10.1007/s00236-021-00396-9 SN - 0001-5903 SN - 1432-0525 VL - 58 IS - 4 SP - 263 EP - 279 PB - Springer CY - Berlin ; Heidelberg ; New York, NY ER - TY - JOUR A1 - Bordihn, Henning A1 - Holzer, Markus T1 - On the number of active states in finite automata JF - Acta informatica N2 - We introduce a new measure of descriptional complexity on finite automata, called the number of active states. Roughly speaking, the number of active states of an automaton A on input w counts the number of different states visited during the most economic computation of the automaton A for the word w. This concept generalizes to finite automata and regular languages in a straightforward way. We show that the number of active states of both finite automata and regular languages is computable, even with respect to nondeterministic finite automata. We further compare the number of active states to related measures for regular languages. In particular, we show incomparability to the radius of regular languages and that the difference between the number of active states and the total number of states needed in finite automata for a regular language can be of exponential order. Y1 - 2021 U6 - https://doi.org/10.1007/s00236-021-00397-8 SN - 0001-5903 SN - 1432-0525 VL - 58 IS - 4 SP - 301 EP - 318 PB - Springer CY - Berlin ; Heidelberg [u.a.] ER - TY - JOUR A1 - Kreowsky, Philipp A1 - Stabernack, Christian Benno T1 - A full-featured FPGA-based pipelined architecture for SIFT extraction JF - IEEE access : practical research, open solutions / Institute of Electrical and Electronics Engineers N2 - Image feature detection is a key task in computer vision. Scale Invariant Feature Transform (SIFT) is a prevalent and well known algorithm for robust feature detection. However, it is computationally demanding and software implementations are not applicable for real-time performance. In this paper, a versatile and pipelined hardware implementation is proposed, that is capable of computing keypoints and rotation invariant descriptors on-chip. All computations are performed in single precision floating-point format which makes it possible to implement the original algorithm with little alteration. Various rotation resolutions and filter kernel sizes are supported for images of any resolution up to ultra-high definition. For full high definition images, 84 fps can be processed. Ultra high definition images can be processed at 21 fps. KW - Field programmable gate arrays KW - Convolution KW - Signal processing KW - algorithms KW - Kernel KW - Image resolution KW - Histograms KW - Feature extraction KW - Scale-invariant feature transform (SIFT) KW - field-programmable gate array KW - (FPGA) KW - image processing KW - computer vision KW - parallel processing KW - architecture KW - real-time KW - hardware architecture Y1 - 2021 U6 - https://doi.org/10.1109/ACCESS.2021.3104387 SN - 2169-3536 VL - 9 SP - 128564 EP - 128573 PB - Inst. of Electr. and Electronics Engineers CY - New York, NY ER - TY - JOUR A1 - Bauer, Chris A1 - Herwig, Ralf A1 - Lienhard, Matthias A1 - Prasse, Paul A1 - Scheffer, Tobias A1 - Schuchhardt, Johannes T1 - Large-scale literature mining to assess the relation between anti-cancer drugs and cancer types JF - Journal of translational medicine N2 - Background: There is a huge body of scientific literature describing the relation between tumor types and anti-cancer drugs. The vast amount of scientific literature makes it impossible for researchers and physicians to extract all relevant information manually. Methods: In order to cope with the large amount of literature we applied an automated text mining approach to assess the relations between 30 most frequent cancer types and 270 anti-cancer drugs. We applied two different approaches, a classical text mining based on named entity recognition and an AI-based approach employing word embeddings. The consistency of literature mining results was validated with 3 independent methods: first, using data from FDA approvals, second, using experimentally measured IC-50 cell line data and third, using clinical patient survival data. Results: We demonstrated that the automated text mining was able to successfully assess the relation between cancer types and anti-cancer drugs. All validation methods showed a good correspondence between the results from literature mining and independent confirmatory approaches. The relation between most frequent cancer types and drugs employed for their treatment were visualized in a large heatmap. All results are accessible in an interactive web-based knowledge base using the following link: . Conclusions: Our approach is able to assess the relations between compounds and cancer types in an automated manner. Both, cancer types and compounds could be grouped into different clusters. Researchers can use the interactive knowledge base to inspect the presented results and follow their own research questions, for example the identification of novel indication areas for known drugs. KW - Literature mining KW - Anti-cancer drugs KW - Tumor types KW - Word embeddings KW - Database Y1 - 2021 U6 - https://doi.org/10.1186/s12967-021-02941-z SN - 1479-5876 VL - 19 IS - 1 PB - BioMed Central CY - London ER - TY - JOUR A1 - Huang, Yizhen A1 - Richter, Eric A1 - Kleickmann, Thilo A1 - Wiepke, Axel A1 - Richter, Dirk T1 - Classroom complexity affects student teachers’ behavior in a VR classroom JF - Computers & education : an international journal N2 - Student teachers often struggle to keep track of everything that is happening in the classroom, and particularly to notice and respond when students cause disruptions. The complexity of the classroom environment is a potential contributing factor that has not been empirically tested. In this experimental study, we utilized a virtual reality (VR) classroom to examine whether classroom complexity affects the likelihood of student teachers noticing disruptions and how they react after noticing. Classroom complexity was operationalized as the number of disruptions and the existence of overlapping disruptions (multidimensionality) as well as the existence of parallel teaching tasks (simultaneity). Results showed that student teachers (n = 50) were less likely to notice the scripted disruptions, and also less likely to respond to the disruptions in a comprehensive and effortful manner when facing greater complexity. These results may have implications for both teacher training and the design of VR for training or research purpose. This study contributes to the field from two aspects: 1) it revealed how features of the classroom environment can affect student teachers' noticing of and reaction to disruptions; and 2) it extends the functionality of the VR environment-from a teacher training tool to a testbed of fundamental classroom processes that are difficult to manipulate in real-life. KW - Augmented and virtual reality KW - Simulations KW - Improving classroom KW - teaching KW - Media in education KW - Pedagogical issues Y1 - 2021 U6 - https://doi.org/10.1016/j.compedu.2020.104100 SN - 0360-1315 SN - 1873-782X VL - 163 PB - Elsevier CY - Oxford ER - TY - JOUR A1 - Hawro, Tomasz A1 - Przybylowicz, Katarzyna A1 - Spindler, Max A1 - Hawro, Marlena A1 - Steć, Michał A1 - Altrichter, Sabine A1 - Weller, Karsten A1 - Magerl, Markus A1 - Reidel, Ulrich A1 - Alarbeed, Ezzat A1 - Alraboni, Ola A1 - Maurer, Marcus A1 - Metz, Martin T1 - The characteristics and impact of pruritus in adult dermatology patients BT - a prospective, cross-sectional study JF - Journal of the American Academy of Dermatology N2 - Background: Pruritus often accompanies chronic skin diseases, exerting considerable burden on many areas of patient functioning; this burden and the features of pruritus remain insufficiently characterized. Objective: To investigate characteristics, including localization patterns, and burden of pruritus in patients with chronic dermatoses. Methods: We recruited 800 patients with active chronic skin diseases. We assessed pruritus intensity, localization, and further characteristics. We used validated questionnaires to assess quality of life, work productivity and activity impairment, anxiety, depression, and sleep quality. Results: Nine out of every 10 patients had experienced pruritus throughout their disease and 73% in the last 7 days. Pruritus often affected the entire body and was not restricted to skin lesions. Patients with moderate to severe pruritus reported significantly more impairment to their sleep quality and work productivity, and they were more depressed and anxious than control individuals and patients with mild or no pruritus. Suicidal ideations were highly prevalent in patients with chronic pruritus (18.5%) and atopic dermatitis (11.8%). Conclusions: Pruritus prevalence and intensity are very high across all dermatoses studied; intensity is linked to impairment in many areas of daily functioning. Effective treatment strategies are urgently required to treat pruritus and the underlying skin disease. ( J Am Acad Dermatol 2021;84:691-700.) KW - activity KW - anxiety KW - depression KW - pruritus KW - quality of life KW - sleep quality KW - suicidal ideations KW - work productivity Y1 - 2021 U6 - https://doi.org/10.1016/J.JAAD.2020.08.035 SN - 0190-9622 SN - 1097-6787 VL - 84 IS - 3 SP - 691 EP - 700 PB - Elsevier CY - Amsterdam [u.a.] ER - TY - JOUR A1 - Middelanis, Robin A1 - Willner, Sven N. A1 - Otto, Christian A1 - Kuhla, Kilian A1 - Quante, Lennart A1 - Levermann, Anders T1 - Wave-like global economic ripple response to Hurricane Sandy JF - Environmental research letters : ERL / Institute of Physics N2 - Tropical cyclones range among the costliest disasters on Earth. Their economic repercussions along the supply and trade network also affect remote economies that are not directly affected. We here simulate possible global repercussions on consumption for the example case of Hurricane Sandy in the US (2012) using the shock-propagation model Acclimate. The modeled shock yields a global three-phase ripple: an initial production demand reduction and associated consumption price decrease, followed by a supply shortage with increasing prices, and finally a recovery phase. Regions with strong trade relations to the US experience strong magnitudes of the ripple. A dominating demand reduction or supply shortage leads to overall consumption gains or losses of a region, respectively. While finding these repercussions in historic data is challenging due to strong volatility of economic interactions, numerical models like ours can help to identify them by approaching the problem from an exploratory angle, isolating the effect of interest. For this, our model simulates the economic interactions of over 7000 regional economic sectors, interlinked through about 1.8 million trade relations. Under global warming, the wave-like structures of the economic response to major hurricanes like the one simulated here are likely to intensify and potentially overlap with other weather extremes. KW - supply chains KW - Hurricane Sandy KW - economic ripples KW - extreme weather KW - impacts KW - loss propagation KW - natural disasters Y1 - 2021 U6 - https://doi.org/10.1088/1748-9326/ac39c0 SN - 1748-9326 VL - 16 IS - 12 PB - IOP Publ. Ltd. CY - Bristol ER - TY - JOUR A1 - Quante, Lennart A1 - Willner, Sven N. A1 - Middelanis, Robin A1 - Levermann, Anders T1 - Regions of intensification of extreme snowfall under future warming JF - Scientific reports N2 - Due to climate change the frequency and character of precipitation are changing as the hydrological cycle intensifies. With regards to snowfall, global warming has two opposing influences; increasing humidity enables intense snowfall, whereas higher temperatures decrease the likelihood of snowfall. Here we show an intensification of extreme snowfall across large areas of the Northern Hemisphere under future warming. This is robust across an ensemble of global climate models when they are bias-corrected with observational data. While mean daily snowfall decreases, both the 99th and the 99.9th percentiles of daily snowfall increase in many regions in the next decades, especially for Northern America and Asia. Additionally, the average intensity of snowfall events exceeding these percentiles as experienced historically increases in many regions. This is likely to pose a challenge to municipalities in mid to high latitudes. Overall, extreme snowfall events are likely to become an increasingly important impact of climate change in the next decades, even if they will become rarer, but not necessarily less intense, in the second half of the century. Y1 - 2021 U6 - https://doi.org/10.1038/s41598-021-95979-4 SN - 2045-2322 VL - 11 IS - 1 PB - Macmillan Publishers Limited, part of Springer Nature CY - Berlin ER -