TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Dengler, Jürgen
A1  - Wagner, Viktoria
A1  - Dembicz, Iwona
A1  - Garcia-Mijangos, Itziar
A1  - Naqinezhad, Alireza
A1  - Boch, Steffen
A1  - Chiarucci, Alessandro
A1  - Conradi, Timo
A1  - Filibeck, Goffredo
A1  - Guarino, Riccardo
A1  - Janisova, Monika
A1  - Steinbauer, Manuel J.
A1  - Acic, Svetlana
A1  - Acosta, Alicia T. R.
A1  - Akasaka, Munemitsu
A1  - Allers, Marc-Andre
A1  - Apostolova, Iva
A1  - Axmanova, Irena
A1  - Bakan, Branko
A1  - Baranova, Alina
A1  - Bardy-Durchhalter, Manfred
A1  - Bartha, Sandor
A1  - Baumann, Esther
A1  - Becker, Thomas
A1  - Becker, Ute
A1  - Belonovskaya, Elena
A1  - Bengtsson, Karin
A1  - Benito Alonso, Jose Luis
A1  - Berastegi, Asun
A1  - Bergamini, Ariel
A1  - Bonini, Ilaria
A1  - Bruun, Hans Henrik
A1  - Budzhak, Vasyl
A1  - Bueno, Alvaro
A1  - Antonio Campos, Juan
A1  - Cancellieri, Laura
A1  - Carboni, Marta
A1  - Chocarro, Cristina
A1  - Conti, Luisa
A1  - Czarniecka-Wiera, Marta
A1  - De Frenne, Pieter
A1  - Deak, Balazs
A1  - Didukh, Yakiv P.
A1  - Diekmann, Martin
A1  - Dolnik, Christian
A1  - Dupre, Cecilia
A1  - Ecker, Klaus
A1  - Ermakov, Nikolai
A1  - Erschbamer, Brigitta
A1  - Escudero, Adrian
A1  - Etayo, Javier
A1  - Fajmonova, Zuzana
A1  - Felde, Vivian A.
A1  - Fernandez Calzado, Maria Rosa
A1  - Finckh, Manfred
A1  - Fotiadis, Georgios
A1  - Fracchiolla, Mariano
A1  - Ganeva, Anna
A1  - Garcia-Magro, Daniel
A1  - Gavilan, Rosario G.
A1  - Germany, Markus
A1  - Giladi, Itamar
A1  - Gillet, Francois
A1  - Giusso del Galdo, Gian Pietro
A1  - Gonzalez, Jose M.
A1  - Grytnes, John-Arvid
A1  - Hajek, Michal
A1  - Hajkova, Petra
A1  - Helm, Aveliina
A1  - Herrera, Mercedes
A1  - Hettenbergerova, Eva
A1  - Hobohm, Carsten
A1  - Huellbusch, Elisabeth M.
A1  - Ingerpuu, Nele
A1  - Jandt, Ute
A1  - Jeltsch, Florian
A1  - Jensen, Kai
A1  - Jentsch, Anke
A1  - Jeschke, Michael
A1  - Jimenez-Alfaro, Borja
A1  - Kacki, Zygmunt
A1  - Kakinuma, Kaoru
A1  - Kapfer, Jutta
A1  - Kavgaci, Ali
A1  - Kelemen, Andras
A1  - Kiehl, Kathrin
A1  - Koyama, Asuka
A1  - Koyanagi, Tomoyo F.
A1  - Kozub, Lukasz
A1  - Kuzemko, Anna
A1  - Kyrkjeeide, Magni Olsen
A1  - Landi, Sara
A1  - Langer, Nancy
A1  - Lastrucci, Lorenzo
A1  - Lazzaro, Lorenzo
A1  - Lelli, Chiara
A1  - Leps, Jan
A1  - Loebel, Swantje
A1  - Luzuriaga, Arantzazu L.
A1  - Maccherini, Simona
A1  - Magnes, Martin
A1  - Malicki, Marek
A1  - Marceno, Corrado
A1  - Mardari, Constantin
A1  - Mauchamp, Leslie
A1  - May, Felix
A1  - Michelsen, Ottar
A1  - Mesa, Joaquin Molero
A1  - Molnar, Zsolt
A1  - Moysiyenko, Ivan Y.
A1  - Nakaga, Yuko K.
A1  - Natcheva, Rayna
A1  - Noroozi, Jalil
A1  - Pakeman, Robin J.
A1  - Palpurina, Salza
A1  - Partel, Meelis
A1  - Paetsch, Ricarda
A1  - Pauli, Harald
A1  - Pedashenko, Hristo
A1  - Peet, Robert K.
A1  - Pielech, Remigiusz
A1  - Pipenbaher, Natasa
A1  - Pirini, Chrisoula
A1  - Pleskova, Zuzana
A1  - Polyakova, Mariya A.
A1  - Prentice, Honor C.
A1  - Reinecke, Jennifer
A1  - Reitalu, Triin
A1  - Pilar Rodriguez-Rojo, Maria
A1  - Rolecek, Jan
A1  - Ronkin, Vladimir
A1  - Rosati, Leonardo
A1  - Rosen, Ejvind
A1  - Ruprecht, Eszter
A1  - Rusina, Solvita
A1  - Sabovljevic, Marko
A1  - Maria Sanchez, Ana
A1  - Savchenko, Galina
A1  - Schuhmacher, Oliver
A1  - Skornik, Sonja
A1  - Sperandii, Marta Gaia
A1  - Staniaszek-Kik, Monika
A1  - Stevanovic-Dajic, Zora
A1  - Stock, Marin
A1  - Suchrow, Sigrid
A1  - Sutcliffe, Laura M. E.
A1  - Swacha, Grzegorz
A1  - Sykes, Martin
A1  - Szabo, Anna
A1  - Talebi, Amir
A1  - Tanase, Catalin
A1  - Terzi, Massimo
A1  - Tolgyesi, Csaba
A1  - Torca, Marta
A1  - Torok, Peter
A1  - Tothmeresz, Bela
A1  - Tsarevskaya, Nadezda
A1  - Tsiripidis, Ioannis
A1  - Tzonev, Rossen
A1  - Ushimaru, Atushi
A1  - Valko, Orsolya
A1  - van der Maarel, Eddy
A1  - Vanneste, Thomas
A1  - Vashenyak, Iuliia
A1  - Vassilev, Kiril
A1  - Viciani, Daniele
A1  - Villar, Luis
A1  - Virtanen, Risto
A1  - Kosic, Ivana Vitasovic
A1  - Wang, Yun
A1  - Weiser, Frank
A1  - Went, Julia
A1  - Wesche, Karsten
A1  - White, Hannah
A1  - Winkler, Manuela
A1  - Zaniewski, Piotr T.
A1  - Zhang, Hui
A1  - Ziv, Yaron
A1  - Znamenskiy, Sergey
A1  - Biurrun, Idoia
T1  - GrassPlot - a database of multi-scale plant diversity in Palaearctic grasslands
JF  - Phytocoenologia
N2  - GrassPlot is a collaborative vegetation-plot database organised by the Eurasian Dry Grassland Group (EDGG) and listed in the Global Index of Vegetation-Plot Databases (GIVD ID EU-00-003). GrassPlot collects plot records (releves) from grasslands and other open habitats of the Palaearctic biogeographic realm. It focuses on precisely delimited plots of eight standard grain sizes (0.0001; 0.001;... 1,000 m(2)) and on nested-plot series with at least four different grain sizes. The usage of GrassPlot is regulated through Bylaws that intend to balance the interests of data contributors and data users. The current version (v. 1.00) contains data for approximately 170,000 plots of different sizes and 2,800 nested-plot series. The key components are richness data and metadata. However, most included datasets also encompass compositional data. About 14,000 plots have near-complete records of terricolous bryophytes and lichens in addition to vascular plants. At present, GrassPlot contains data from 36 countries throughout the Palaearctic, spread across elevational gradients and major grassland types. GrassPlot with its multi-scale and multi-taxon focus complements the larger international vegetationplot databases, such as the European Vegetation Archive (EVA) and the global database " sPlot". Its main aim is to facilitate studies on the scale-and taxon-dependency of biodiversity patterns and drivers along macroecological gradients. GrassPlot is a dynamic database and will expand through new data collection coordinated by the elected Governing Board. We invite researchers with suitable data to join GrassPlot. Researchers with project ideas addressable with GrassPlot data are welcome to submit proposals to the Governing Board.
KW  - biodiversity
KW  - European Vegetation Archive (EVA)
KW  - Eurasian Dry Grassland Group (EDGG)
KW  - grassland vegetation
KW  - GrassPlot
KW  - macroecology
KW  - multi-taxon
KW  - nested plot
KW  - scale-dependence
KW  - species-area relationship (SAR)
KW  - sPlot
KW  - vegetation-plot database
Y1  - 2018
U6  - https://doi.org/10.1127/phyto/2018/0267
SN  - 0340-269X
VL  - 48
IS  - 3
SP  - 331
EP  - 347
PB  - Cramer
CY  - Stuttgart
ER  - 
TY  - JOUR
A1  - Chen, Jun
A1  - Liu, Rui
A1  - Liu, Kai
A1  - Awasthi, Arun Kumar
A1  - Zhang, Peijin
A1  - Wang, Yuming
A1  - Kliem, Bernhard
T1  - Extreme-ultraviolet late phase of solar flares
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - A second peak in the extreme ultraviolet sometimes appears during the gradual phase of solar flares, which is known as the EUV late phase (ELP). Stereotypically ELP is associated with two separated sets of flaring loops with distinct sizes, and it has been debated whether ELP is caused by additional heating or extended plasma cooling in the longer loop system. Here we carry out a survey of 55 M-and-above GOES-class flares with ELP during 2010-2014. Based on the flare-ribbon morphology, these flares are categorized as circular-ribbon (19 events), two-ribbon (23 events), and complex-ribbon (13 events) flares. Among them, 22 events (40%) are associated with coronal mass ejections, while the rest are confined. An extreme ELP, with the late-phase peak exceeding the main-phase peak, is found in 48% of two-ribbon flares, 37% of circular-ribbon flares, and 31% of complex-ribbon flares, suggesting that additional heating is more likely present during ELP in two-ribbon than in circular-ribbon flares. Overall, cooling may be the dominant factor causing the delay of the ELP peak relative to the main-phase peak, because the loop system responsible for the ELP emission is generally larger than, and well separated from, that responsible for the main-phase emission. All but one of the circular-ribbon flares can be well explained by a composite "dome-plate" quasi-separatrix layer (QSL). Only half of these show a magnetic null point, with its fan and spine embedded in the dome and plate, respectively. The dome-plate QSL, therefore, is a general and robust structure characterizing circular-ribbon flares.
Y1  - 2020
U6  - https://doi.org/10.3847/1538-4357/ab6def
SN  - 0004-637X
SN  - 1538-4357
VL  - 890
IS  - 2
PB  - Institute of Physics Publ.
CY  - London
ER  - 
TY  - JOUR
A1  - Xue, Zhike
A1  - Yan, Xiaoli
A1  - Cheng, Xin
A1  - Yang, Liheng
A1  - Su, Yingna
A1  - Kliem, Bernhard
A1  - Zhang, Jun
A1  - Liu, Zhong
A1  - Bi, Yi
A1  - Xiang, Yongyuan
A1  - Yang, Kai
A1  - Zhao, Li
T1  - Observing the release of twist by magnetic reconnection in a solar filament eruption
JF  - Nature Communications
N2  - Magnetic reconnection is a fundamental process of topology change and energy release, taking place in plasmas on the Sun, in space, in astrophysical objects and in the laboratory. However, observational evidence has been relatively rare and typically only partial. Here we present evidence of fast reconnection in a solar filament eruption using high-resolution H-alpha images from the New Vacuum Solar Telescope, supplemented by extreme ultraviolet observations. The reconnection is seen to occur between a set of ambient chromospheric fibrils and the filament itself. This allows for the relaxation of magnetic tension in the filament by an untwisting motion, demonstrating a flux rope structure. The topology change and untwisting are also found through nonlinear force-free field modelling of the active region in combination with magnetohydrodynamic simulation. These results demonstrate a new role for reconnection in solar eruptions: the release of magnetic twist.
Y1  - 2016
U6  - https://doi.org/10.1038/ncomms11837
SN  - 2041-1723
VL  - 7
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Ramisch, Arne
A1  - Lockot, Gregori
A1  - Haberzettl, Torsten
A1  - Hartmann, Kai
A1  - Kuhn, Gerhard
A1  - Lehmkuhl, Frank
A1  - Schimpf, Stefan
A1  - Schulte, Philipp
A1  - Stauch, Georg
A1  - Wang, Rong
A1  - Wunnemann, Bernd
A1  - Yan, Dada
A1  - Zhang, Yongzhan
A1  - Diekmann, Bernhard
T1  - A persistent northern boundary of Indian Summer Monsoon precipitation over Central Asia during the Holocene
JF  - Scientific reports
N2  - Extra-tropical circulation systems impede poleward moisture advection by the Indian Summer Monsoon. In this context, the Himalayan range is believed to insulate the south Asian circulation from extra-tropical influences and to delineate the northern extent of the Indian Summer Monsoon in central Asia. Paleoclimatic evidence, however, suggests increased moisture availability in the Early Holocene north of the Himalayan range which is attributed to an intensification of the Indian Summer Monsoon. Nevertheless, mechanisms leading to a surpassing of the Himalayan range and the northern maximum extent of summer monsoonal influence remain unknown. Here we show that the Kunlun barrier on the northern Tibetan Plateau [similar to 36 degrees N] delimits Indian Summer Monsoon precipitation during the Holocene. The presence of the barrier relocates the insulation effect 1,000 km further north, allowing a continental low intensity branch of the Indian Summer Monsoon which is persistent throughout the Holocene. Precipitation intensities at its northern extent seem to be driven by differentiated solar heating of the Northern Hemisphere indicating dependency on energy-gradients rather than absolute radiation intensities. The identified spatial constraints of monsoonal precipitation will facilitate the prediction of future monsoonal precipitation patterns in Central Asia under varying climatic conditions.
Y1  - 2016
U6  - https://doi.org/10.1038/srep25791
SN  - 2045-2322
VL  - 6
SP  - 596
EP  - 633
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Zhang, Kai
A1  - Chen, Zhiming
A1  - Armin, Ardalan
A1  - Dong, Sheng
A1  - Xia, Ruoxi
A1  - Yip, Hin-Lap
A1  - Shoaee, Safa
A1  - Huang, Fei
A1  - Cao, Yong
T1  - Efficient large area organic solar cells processed by blade-coating with single-component green solvent
JF  - Solar Rrl
N2  - While the performance of laboratory-scale organic solar cells (OSCs) continues to grow, development of high efficiency large area OSCs remains a big challenge. Although a few attempts to produce large area organic solar cells (OSCs) have been reported, there are still challenges on the way to realizing efficient module devices, such as the low compatibility of the thickness-sensitive active layer with large area coating techniques, the frequent need for toxic solvents and tedious optimization processes used during device fabrication. In this work, highly efficient thickness-insensitive OSCs based on PTB7-Th:PC71BM that processed with single-component green solvent 2-methylanisole are presented, in which both junction thickness limitation and solvent toxicity issues are simultaneously addressed. Careful investigation reveals that this green solvent prevents the evolution of PC71BM into large area clusters resulting in reduced charge carrier recombination, and largely eliminates trapping centers, and thus improves the thickness tolerance of the films. These findings enable us to address the scalability and solvent toxicity issues and to fabricate a 16 cm(2) OSC with doctor-blade coating with a state-of-the-art power conversion efficiency of 7.5% using green solvent.
KW  - doctor-blade coating
KW  - green solvents
KW  - large area devices
KW  - organic solar cells
KW  - thickness insensitive active layers
Y1  - 2017
U6  - https://doi.org/10.1002/solr.201700169
SN  - 2367-198X
VL  - 2
IS  - 1
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Armin, Ardalan
A1  - Chen, Zhiming
A1  - Jin, Yaocheng
A1  - Zhang, Kai
A1  - Huang, Fei
A1  - Shoaee, Safa
T1  - A Shockley-Type polymer
BT  - Fullerene solar cell
JF  - Advanced energy materials
N2  - Charge extraction rate in solar cells made of blends of electron donating/accepting organic semiconductors is typically slow due to their low charge carrier mobility. This sets a limit on the active layer thickness and has hindered the industrialization of organic solar cells (OSCs). Herein, charge transport and recombination properties of an efficient polymer (NT812):fullerene blend are investigated. This system delivers power conversion efficiency of >9% even when the junction thickness is as large as 800 nm. Experimental results indicate that this material system exhibits exceptionally low bimolecular recombination constant, 800 times smaller than the diffusion-controlled electron and hole encounter rate. Comparing theoretical results based on a recently introduced modified Shockley model for fill factor, and experiments, clarifies that charge collection is nearly ideal in these solar cells even when the thickness is several hundreds of nanometer. This is the first realization of high-efficiency Shockley-type organic solar cells with junction thicknesses suitable for scaling up.
KW  - charge transport
KW  - non-Langevin recombination
KW  - organic solar cells
KW  - thick junctions
Y1  - 2018
U6  - https://doi.org/10.1002/aenm.201701450
SN  - 1614-6832
SN  - 1614-6840
VL  - 8
IS  - 7
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hosseini, Seyed Mehrdad
A1  - Roland, Steffen
A1  - Kurpiers, Jona
A1  - Chen, Zhiming
A1  - Zhang, Kai
A1  - Huang, Fei
A1  - Armin, Ardalan
A1  - Neher, Dieter
A1  - Shoaee, Safa
T1  - Impact of Bimolecular Recombination on the Fill Factor of Fullerene and Nonfullerene-Based Solar Cells
BT  - A Comparative Study of Charge Generation and Extraction
JF  - The journal of physical chemistry : C, Nanomaterials and interfaces
N2  - Power conversion efficiencies of donor/acceptor organic solar cells utilizing nonfullerene acceptors have now increased beyond the record of their fullerene-based counterparts. There remain many fundamental questions regarding nanomorphology, interfacial states, charge generation and extraction, and losses in these systems. Herein, we present a comparative study of bulk heterojunction solar cells composed of a recently introduced naphthothiadiazole-based polymer (NT812) as the electron donor and two different acceptor molecules, namely, [6,6]-phenyl-C71-butyric acid methyl ester (PCBM)[70] and 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone))-5,5,11,11-tetrakis(4-hexylphenyl)-dithieno[2,3-d:2′,3′-d′]-s-indaceno[1,2-b:5,6-b′]dithiophene (ITIC). A comparison between the photovoltaic performance of these two types of solar cells reveals that the open-circuit voltage (Voc) of the NT812:ITIC-based solar cell is larger, but the fill factor (FF) is lower than that of the NT812:PCBM[70] device. We find the key reason behind this reduced FF in the ITIC-based device to be faster nongeminate recombination relative to the NT812:PCBM[70] system.
Y1  - 2019
U6  - https://doi.org/10.1021/acs.jpcc.8b11669
SN  - 1932-7447
VL  - 123
IS  - 11
SP  - 6823
EP  - 6830
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Jia, Weihan
A1  - Anslan, Sten
A1  - Chen, Fahu
A1  - Cao, Xianyong
A1  - Dong, Hailiang
A1  - Dulias, Katharina
A1  - Gu, Zhengquan
A1  - Heinecke, Liv
A1  - Jiang, Hongchen
A1  - Kruse, Stefan
A1  - Kang, Wengang
A1  - Li, Kai
A1  - Liu, Sisi
A1  - Liu, Xingqi
A1  - Liu, Ying
A1  - Ni, Jian
A1  - Schwalb, Antje
A1  - Stoof-Leichsenring, Kathleen R.
A1  - Shen, Wei
A1  - Tian, Fang
A1  - Wang, Jing
A1  - Wang, Yongbo
A1  - Wang, Yucheng
A1  - Xu, Hai
A1  - Yang, Xiaoyan
A1  - Zhang, Dongju
A1  - Herzschuh, Ulrike
T1  - Sedimentary ancient DNA reveals past ecosystem and biodiversity changes on the Tibetan Plateau: overview and prospects
JF  - Quaternary science reviews : the international multidisciplinary research and review journal
N2  - Alpine ecosystems on the Tibetan Plateau are being threatened by ongoing climate warming and intensified human activities. Ecological time-series obtained from sedimentary ancient DNA (sedaDNA) are essential for understanding past ecosystem and biodiversity dynamics on the Tibetan Plateau and their responses to climate change at a high taxonomic resolution. Hitherto only few but promising studies have been published on this topic. The potential and limitations of using sedaDNA on the Tibetan Plateau are not fully understood. Here, we (i) provide updated knowledge of and a brief introduction to the suitable archives, region-specific taphonomy, state-of-the-art methodologies, and research questions of sedaDNA on the Tibetan Plateau; (ii) review published and ongoing sedaDNA studies from the Tibetan Plateau; and (iii) give some recommendations for future sedaDNA study designs. Based on the current knowledge of taphonomy, we infer that deep glacial lakes with freshwater and high clay sediment input, such as those from the southern and southeastern Tibetan Plateau, may have a high potential for sedaDNA studies. Metabarcoding (for microorganisms and plants), metagenomics (for ecosystems), and hybridization capture (for prehistoric humans) are three primary sedaDNA approaches which have been successfully applied on the Tibetan Plateau, but their power is still limited by several technical issues, such as PCR bias and incompleteness of taxonomic reference databases. Setting up high-quality and open-access regional taxonomic reference databases for the Tibetan Plateau should be given priority in the future. To conclude, the archival, taphonomic, and methodological conditions of the Tibetan Plateau are favorable for performing sedaDNA studies. More research should be encouraged to address questions about long-term ecological dynamics at ecosystem scale and to bring the paleoecology of the Tibetan Plateau into a new era.
KW  - Sedimentary ancient DNA (sedaDNA)
KW  - Tibetan Plateau
KW  - Environmental DNA
KW  - Taphonomy
KW  - Ecosystem
KW  - Biodiversity
KW  - Paleoecology
KW  - Paleogeography
Y1  - 2022
U6  - https://doi.org/10.1016/j.quascirev.2022.107703
SN  - 0277-3791
SN  - 1873-457X
VL  - 293
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Zhang, Di
A1  - Cao, Kai
A1  - Yuan, Xiaoping
A1  - Wang, Guocan
A1  - van der Beek, Pieter A.
T1  - Late Oligocene-early Miocene origin of the First Bend of the Yangtze River explained by thrusting-induced river reorganization
JF  - Geomorphology
N2  - The origin of the First Bend of the Yangtze River is key to understanding the birth of the modern Yangtze River. Despite considerable efforts, the timing and mechanism of formation of the First Bend remain highly debated. Inverse river-profile modeling of three tributaries (Chongjiang, Lima, and Gudu) of the Jinsha River, integrated with regional tectonic and geomorphic interpretations, allows the onset of incision at the First Bend to be constrained to 28-20 Ma. The spatio-temporal coincidence of initial river incision and activity of Yulong Thrust Belt in southeastern Tibet highlights thrusting to be fundamental in reshaping the pre-existing stream network at the First Bend. These results enable us to reinterpret a change in sedimentary environment from a braided river to a swamp-like lake in the Jianchuan Basin south of the First Bend, recording the destruction of the hypothesized southwards-flowing paleo-Jinsha and Shuiluo Rivers at ~36-35 Ma by magmatism. During the late Oligoceneearly Miocene, the paleo-Shuiluo River was diverted to the north by focused rock uplift due to thrusting along the Yulong Thrust Belt, which also led to exhumation of the Jianchuan Basin. Diversion of the paleo-Shuiluo River can be explained by capture from a downstream river in the footwall of the Yulong Thrust Belt. Subsequent rapid headward erosion, that was caused by thrusting-induced drop of local base level, is recorded by upstream younging ages for the onset of incision and led to the formation of the First Bend. The combination of new ages for the onset of incision at 28-20 Ma at the First Bend and younger ages upstream indicates northwards expansion of the Jinsha River at a rate of 62 +/- 18 mm/yr. Our results suggest that the origin of the First Bend was likely triggered by thrusting at 28-20 Ma, after which the Yangtze River formed.
KW  - Tibetan Plateau
KW  - Yangtze River
KW  - river incision
KW  - inverse modeling
Y1  - 2022
U6  - https://doi.org/10.1016/j.geomorph.2022.108303
SN  - 0169-555X
SN  - 1872-695X
VL  - 411
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  - 
TY  - JOUR
A1  - Brinkmann, Kai Oliver
A1  - Becker, Tim
A1  - Zimmermann, Florian
A1  - Kreusel, Cedric
A1  - Gahlmann, Tobias
A1  - Theisen, Manuel
A1  - Haeger, Tobias
A1  - Olthof, Selina
A1  - Tückmantel, Christian
A1  - Günster, M.
A1  - Maschwitz, Timo
A1  - Göbelsmann, Fabian
A1  - Koch, Christine
A1  - Hertel, Dirk
A1  - Caprioglio, Pietro
A1  - Peña-Camargo, Francisco
A1  - Perdigón-Toro, Lorena
A1  - Al-Ashouri, Amran
A1  - Merten, Lena
A1  - Hinderhofer, Alexander
A1  - Gomell, Leonie
A1  - Zhang, Siyuan
A1  - Schreiber, Frank
A1  - Albrecht, Steve
A1  - Meerholz, Klaus
A1  - Neher, Dieter
A1  - Stolterfoht, Martin
A1  - Riedl, Thomas
T1  - Perovskite-organic tandem solar cells with indium oxide interconnect
JF  - Nature
N2  - Multijunction solar cells can overcome the fundamental efficiency limits of single-junction devices. The bandgap tunability of metal halide perovskite solar cells renders them attractive for multijunction architectures(1). Combinations with silicon and copper indium gallium selenide (CIGS), as well as all-perovskite tandem cells, have been reported(2-5). Meanwhile, narrow-gap non-fullerene acceptors have unlocked skyrocketing efficiencies for organic solar cells(6,7). Organic and perovskite semiconductors are an attractive combination, sharing similar processing technologies. Currently, perovskite-organic tandems show subpar efficiencies and are limited by the low open-circuit voltage (V-oc) of wide-gap perovskite cells(8) and losses introduced by the interconnect between the subcells(9,10). Here we demonstrate perovskite-organic tandem cells with an efficiency of 24.0 per cent (certified 23.1 per cent) and a high V-oc of 2.15 volts. Optimized charge extraction layers afford perovskite subcells with an outstanding combination of high V-oc and fill factor. The organic subcells provide a high external quantum efficiency in the near-infrared and, in contrast to paradigmatic concerns about limited photostability of non-fullerene cells(11), show an outstanding operational stability if excitons are predominantly generated on the non-fullerene acceptor, which is the case in our tandems. The subcells are connected by an ultrathin (approximately 1.5 nanometres) metal-like indium oxide layer with unprecedented low optical/electrical losses. This work sets a milestone for perovskite-organic tandems, which outperform the best p-i-n perovskite single junctions(12) and are on a par with perovskite-CIGS and all-perovskite multijunctions(13).
Y1  - 2022
U6  - https://doi.org/10.1038/s41586-022-04455-0
SN  - 0028-0836
SN  - 1476-4687
VL  - 604
IS  - 7905
SP  - 280
EP  - 286
PB  - Nature Research
CY  - Berlin
ER  - 
TY  - GEN
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
T2  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
T3  - Zweitveröffentlichungen der Universität Potsdam : Reihe der Digital Engineering Fakultät - 19 
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-565379
IS  - 19
ER  - 
TY  - JOUR
A1  - Gorski, Mathias
A1  - Jung, Bettina
A1  - Li, Yong
A1  - Matias-Garcia, Pamela R.
A1  - Wuttke, Matthias
A1  - Coassin, Stefan
A1  - Thio, Chris H. L.
A1  - Kleber, Marcus E.
A1  - Winkler, Thomas W.
A1  - Wanner, Veronika
A1  - Chai, Jin-Fang
A1  - Chu, Audrey Y.
A1  - Cocca, Massimiliano
A1  - Feitosa, Mary F.
A1  - Ghasemi, Sahar
A1  - Hoppmann, Anselm
A1  - Horn, Katrin
A1  - Li, Man
A1  - Nutile, Teresa
A1  - Scholz, Markus
A1  - Sieber, Karsten B.
A1  - Teumer, Alexander
A1  - Tin, Adrienne
A1  - Wang, Judy
A1  - Tayo, Bamidele O.
A1  - Ahluwalia, Tarunveer S.
A1  - Almgren, Peter
A1  - Bakker, Stephan J. L.
A1  - Banas, Bernhard
A1  - Bansal, Nisha
A1  - Biggs, Mary L.
A1  - Boerwinkle, Eric
A1  - Böttinger, Erwin
A1  - Brenner, Hermann
A1  - Carroll, Robert J.
A1  - Chalmers, John
A1  - Chee, Miao-Li
A1  - Chee, Miao-Ling
A1  - Cheng, Ching-Yu
A1  - Coresh, Josef
A1  - de Borst, Martin H.
A1  - Degenhardt, Frauke
A1  - Eckardt, Kai-Uwe
A1  - Endlich, Karlhans
A1  - Franke, Andre
A1  - Freitag-Wolf, Sandra
A1  - Gampawar, Piyush
A1  - Gansevoort, Ron T.
A1  - Ghanbari, Mohsen
A1  - Gieger, Christian
A1  - Hamet, Pavel
A1  - Ho, Kevin
A1  - Hofer, Edith
A1  - Holleczek, Bernd
A1  - Foo, Valencia Hui Xian
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Josyula, Navya Shilpa
A1  - Kahonen, Mika
A1  - Khor, Chiea-Chuen
A1  - Koenig, Wolfgang
A1  - Kramer, Holly
A1  - Kraemer, Bernhard K.
A1  - Kuehnel, Brigitte
A1  - Lange, Leslie A.
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Loos, Ruth J. F.
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Milaneschi, Yuri
A1  - Mishra, Pashupati P.
A1  - Mononen, Nina
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - O'Donoghue, Michelle L.
A1  - Orho-Melander, Marju
A1  - Pendergrass, Sarah A.
A1  - Penninx, Brenda W. J. H.
A1  - Preuss, Michael H.
A1  - Psaty, Bruce M.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Rosenkranz, Alexander R.
A1  - Rossing, Peter
A1  - Rotter, Jerome
A1  - Sabanayagam, Charumathi
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Schoettker, Ben
A1  - Schulz, Christina-Alexandra
A1  - Sedaghat, Sanaz
A1  - Shaffer, Christian M.
A1  - Strauch, Konstantin
A1  - Szymczak, Silke
A1  - Taylor, Kent D.
A1  - Tremblay, Johanne
A1  - Chaker, Layal
A1  - van der Harst, Pim
A1  - van der Most, Peter J.
A1  - Verweij, Niek
A1  - Voelker, Uwe
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Waterworth, Dawn M.
A1  - White, Harvey D.
A1  - Wilson, James G.
A1  - Wong, Tien-Yin
A1  - Woodward, Mark
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Yan
A1  - Snieder, Harold
A1  - Wanner, Christoph
A1  - Boger, Carsten A.
A1  - Kottgen, Anna
A1  - Kronenberg, Florian
A1  - Pattaro, Cristian
A1  - Heid, Iris M.
T1  - Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
JF  - Kidney international : official journal of the International Society of Nephrology
N2  - Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m(2)/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m(2) at follow-up among those with eGFRcrea 60 mL/min/1.73m(2) or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or (LARP4B). Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
KW  - acute kidney injury
KW  - end-stage kidney disease
KW  - genome-wide association
KW  - study
KW  - rapid eGFRcrea decline
Y1  - 2020
U6  - https://doi.org/10.1016/j.kint.2020.09.030
SN  - 0085-2538
SN  - 1523-1755
VL  - 99
IS  - 4
SP  - 926
EP  - 939
PB  - Elsevier
CY  - New York
ER  - 
TY  - JOUR
A1  - Zhang, Kai
A1  - Hu, Jiege
A1  - Yang, Shuai
A1  - Xu, Wei
A1  - Wang, Zhichao
A1  - Zhuang, Peiwen
A1  - Grossart, Hans-Peter
A1  - Luo, Zhuhua
T1  - Biodegradation of polyester polyurethane by the marine fungus Cladosporium halotolerans 6UPA1
JF  - Journal of hazardous materials
N2  - Lack of degradability and the accumulation of polymeric wastes increase the risk for the health of the environment. Recently, recycling of polymeric waste materials becomes increasingly important as raw materials for polymer synthesis are in short supply due to the rise in price and supply chain disruptions. As an important polymer, polyurethane (PU) is widely used in modern life, therefore, PU biodegradation is desirable to avoid its accumulation in the environment. In this study, we isolated a fungal strain Cladosporium halotolerans from the deep sea which can grow in mineral medium with a polyester PU (Impranil DLN) as a sole carbon source. Further, we demonstrate that it can degrade up to 80% of Impranil PU after 3 days of incubation at 28 celcius by breaking the carbonyl groups (1732 cm(-1)) and C-N-H bonds (1532 cm(-1) and 1247 cm(-1)) as confirmed by Fourier-transform infrared (FTIR) spectroscopy analysis. Gas chromatography-mass spectrometry (GC-MS) analysis revealed polyols and alkanes as PU degradation intermediates, indicating the hydrolysis of ester and urethane bonds. Esterase and urease activities were detected in 7 days-old cultures with PU as a carbon source. Transcriptome analysis showed a number of extracellular protein genes coding for enzymes such as cutinase, lipase, peroxidase and hydrophobic surface binding proteins A (HsbA) were expressed when cultivated on Impranil PU. The yeast two-hybrid assay revealed that the hydrophobic surface binding protein ChHsbA1 directly interacts with inducible esterases, ChLip1 (lipase) and ChCut1 (cutinase). Further, the KEGG pathway for "fatty acid degradation " was significantly enriched in Impranil PU inducible genes, indicating that the fungus may use the degradation intermediates to generate energy via this pathway. Taken together, our data indicates secretion of both esterase and hydrophobic surface binding proteins by C. halotolerans plays an important role in Impranil PU absorption and subsequent degradation. Our study provides a mechanistic insight into Impranil PU biodegradation by deep sea fungi and provides the basis for future development of biotechnological PU recycling.
KW  - Impranil PU degradation
KW  - Lipase
KW  - Cutinase
KW  - HsbA
KW  - Fatty acid degradation
Y1  - 2022
U6  - https://doi.org/10.1016/j.jhazmat.2022.129406
SN  - 0304-3894
SN  - 1873-3336
VL  - 437
PB  - Elsevier
CY  - Amsterdam
ER  -