TY  - JOUR
A1  - Jia, Weihan
A1  - Anslan, Sten
A1  - Chen, Fahu
A1  - Cao, Xianyong
A1  - Dong, Hailiang
A1  - Dulias, Katharina
A1  - Gu, Zhengquan
A1  - Heinecke, Liv
A1  - Jiang, Hongchen
A1  - Kruse, Stefan
A1  - Kang, Wengang
A1  - Li, Kai
A1  - Liu, Sisi
A1  - Liu, Xingqi
A1  - Liu, Ying
A1  - Ni, Jian
A1  - Schwalb, Antje
A1  - Stoof-Leichsenring, Kathleen R.
A1  - Shen, Wei
A1  - Tian, Fang
A1  - Wang, Jing
A1  - Wang, Yongbo
A1  - Wang, Yucheng
A1  - Xu, Hai
A1  - Yang, Xiaoyan
A1  - Zhang, Dongju
A1  - Herzschuh, Ulrike
T1  - Sedimentary ancient DNA reveals past ecosystem and biodiversity changes on the Tibetan Plateau: overview and prospects
JF  - Quaternary science reviews : the international multidisciplinary research and review journal
N2  - Alpine ecosystems on the Tibetan Plateau are being threatened by ongoing climate warming and intensified human activities. Ecological time-series obtained from sedimentary ancient DNA (sedaDNA) are essential for understanding past ecosystem and biodiversity dynamics on the Tibetan Plateau and their responses to climate change at a high taxonomic resolution. Hitherto only few but promising studies have been published on this topic. The potential and limitations of using sedaDNA on the Tibetan Plateau are not fully understood. Here, we (i) provide updated knowledge of and a brief introduction to the suitable archives, region-specific taphonomy, state-of-the-art methodologies, and research questions of sedaDNA on the Tibetan Plateau; (ii) review published and ongoing sedaDNA studies from the Tibetan Plateau; and (iii) give some recommendations for future sedaDNA study designs. Based on the current knowledge of taphonomy, we infer that deep glacial lakes with freshwater and high clay sediment input, such as those from the southern and southeastern Tibetan Plateau, may have a high potential for sedaDNA studies. Metabarcoding (for microorganisms and plants), metagenomics (for ecosystems), and hybridization capture (for prehistoric humans) are three primary sedaDNA approaches which have been successfully applied on the Tibetan Plateau, but their power is still limited by several technical issues, such as PCR bias and incompleteness of taxonomic reference databases. Setting up high-quality and open-access regional taxonomic reference databases for the Tibetan Plateau should be given priority in the future. To conclude, the archival, taphonomic, and methodological conditions of the Tibetan Plateau are favorable for performing sedaDNA studies. More research should be encouraged to address questions about long-term ecological dynamics at ecosystem scale and to bring the paleoecology of the Tibetan Plateau into a new era.
KW  - Sedimentary ancient DNA (sedaDNA)
KW  - Tibetan Plateau
KW  - Environmental DNA
KW  - Taphonomy
KW  - Ecosystem
KW  - Biodiversity
KW  - Paleoecology
KW  - Paleogeography
Y1  - 2022
U6  - https://doi.org/10.1016/j.quascirev.2022.107703
SN  - 0277-3791
SN  - 1873-457X
VL  - 293
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Guo, Ranran
A1  - Tian, Ye
A1  - Yang, Yueqi
A1  - Jiang, Qin
A1  - Wang, Yajun
A1  - Yang, Wuli
T1  - A Yolk-Shell nanoplatform for gene-silencing-enhanced photolytic ablation of cancer
JF  - Advanced functional materials
N2  - Noninvasive near-infrared (NIR) light responsive therapy is a promising cancer treatment modality; however, some inherent drawbacks of conventional phototherapy heavily restrict its application in clinic. Rather than producing heat or reactive oxygen species in conventional NIR treatment, here a multifunctional yolk-shell nanoplatform is proposed that is able to generate microbubbles to destruct cancer cells upon NIR laser irradiation. Besides, the therapeutic effect is highly improved through the coalition of small interfering RNA (siRNA), which is codelivered by the nanoplatform. In vitro experiments demonstrate that siRNA significantly inhibits expression of protective proteins and reduces the tolerance of cancer cells to bubble-induced environmental damage. In this way, higher cytotoxicity is achieved by utilizing the yolk-shell nanoparticles than treated with the same nanoparticles missing siRNA under NIR laser irradiation. After surface modification with polyethylene glycol and transferrin, the yolk-shell nanoparticles can target tumors selectively, as demonstrated from the photoacoustic and ultrasonic imaging in vivo. The yolk-shell nanoplatform shows outstanding tumor regression with minimal side effects under NIR laser irradiation. Therefore, the multifunctional nanoparticles that combining bubble-induced mechanical effect with RNA interference are expected to be an effective NIR light responsive oncotherapy.
KW  - cancer
KW  - gene silencing
KW  - near-infrared absorption
KW  - photolytic ablation
KW  - yolk-shell nanoparticles
Y1  - 2018
U6  - https://doi.org/10.1002/adfm.201706398
SN  - 1616-301X
SN  - 1616-3028
VL  - 28
IS  - 14
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Yang, Jin
A1  - Ghosh, Samrat
A1  - Roeser, Jérôme
A1  - Acharjya, Amitava
A1  - Penschke, Christopher
A1  - Tsutsui, Yusuke
A1  - Rabeah, Jabor
A1  - Wang, Tianyi
A1  - Tameu, Simon Yves Djoko
A1  - Ye, Meng-Yang
A1  - Grüneberg, Julia
A1  - Li, Shuang
A1  - Li, Changxia
A1  - Schomaecker, Reinhard
A1  - Van de Krol, Roel
A1  - Seki, Shu
A1  - Saalfrank, Peter
A1  - Thomas, Arne
T1  - Constitutional isomerism of the linkages in donor–acceptor covalent organic frameworks and its impact on photocatalysis
JF  - Nature Communications
N2  - When new covalent organic frameworks (COFs) are designed, the main efforts are typically focused on selecting specific building blocks with certain geometries and properties to control the structure and function of the final COFs. The nature of the linkage (imine, boroxine, vinyl, etc.) between these building blocks naturally also defines their properties. However, besides the linkage type, the orientation, i.e., the constitutional isomerism of these linkages, has rarely been considered so far as an essential aspect. In this work, three pairs of constitutionally isomeric imine-linked donor-acceptor (D-A) COFs are synthesized, which are different in the orientation of the imine bonds (D-C=N-A (DCNA) and D-N=C-A (DNCA)). The constitutional isomers show substantial differences in their photophysical properties and consequently in their photocatalytic performance. Indeed, all DCNA COFs show enhanced photocatalytic H2 evolution performance than the corresponding DNCA COFs. Besides the imine COFs shown here, it can be concluded that the proposed concept of constitutional isomerism of linkages in COFs is quite universal and should be considered when designing and tuning the properties of COFs.
Y1  - 2022
U6  - https://doi.org/10.1038/s41467-022-33875-9
SN  - 2041-1723
VL  - 13
IS  - 1
PB  - Nature Publishing Group UK
CY  - [London]
ER  - 
TY  - JOUR
A1  - Song, Yu
A1  - Li, Gang
A1  - Nowak, Jacqueline
A1  - Zhang, Xiaoqing
A1  - Xu, Dongbei
A1  - Yang, Xiujuan
A1  - Huang, Guoqiang
A1  - Liang, Wanqi
A1  - Yang, Litao
A1  - Wang, Canhua
A1  - Bulone, Vincent
A1  - Nikoloski, Zoran
A1  - Hu, Jianping
A1  - Persson, Staffan
A1  - Zhang, Dabing
T1  - The Rice Actin-Binding Protein RMD Regulates Light-Dependent Shoot Gravitropism
JF  - Plant physiology : an international journal devoted to physiology, biochemistry, cellular and molecular biology, biophysics and environmental biology of plants
N2  - Light and gravity are two key determinants in orientating plant stems for proper growth and development. The organization and dynamics of the actin cytoskeleton are essential for cell biology and critically regulated by actin-binding proteins. However, the role of actin cytoskeleton in shoot negative gravitropism remains controversial. In this work, we report that the actin-binding protein Rice Morphology Determinant (RMD) promotes reorganization of the actin cytoskeleton in rice (Oryza sativa) shoots. The changes in actin organization are associated with the ability of the rice shoots to respond to negative gravitropism. Here, light-grown rmd mutant shoots exhibited agravitropic phenotypes. By contrast, etiolated rmd shoots displayed normal negative shoot gravitropism. Furthermore, we show that RMD maintains an actin configuration that promotes statolith mobility in gravisensing endodermal cells, and for proper auxin distribution in light-grown, but not dark-grown, shoots. RMD gene expression is diurnally controlled and directly repressed by the phytochrome-interacting factor-like protein OsPIL16. Consequently, overexpression of OsPIL16 led to gravisensing and actin patterning defects that phenocopied the rmd mutant. Our findings outline a mechanism that links light signaling and gravity perception for straight shoot growth in rice.
Y1  - 2019
U6  - https://doi.org/10.1104/pp.19.00497
SN  - 0032-0889
SN  - 1532-2548
VL  - 181
IS  - 2
SP  - 630
EP  - 644
PB  - American Society of Plant Physiologists
CY  - Rockville
ER  - 
TY  - JOUR
A1  - Yang, Jie
A1  - Gühr, Markus
A1  - Vecchione, Theodore
A1  - Robinson, Matthew Scott
A1  - Li, Renkai
A1  - Hartmann, Nick
A1  - Shen, Xiaozhe
A1  - Coffee, Ryan
A1  - Corbett, Jeff
A1  - Fry, Alan
A1  - Gaffney, Kelly
A1  - Gorkhover, Tais
A1  - Hast, Carsten
A1  - Jobe, Keith
A1  - Makasyuk, Igor
A1  - Reid, Alexander
A1  - Robinson, Joseph
A1  - Vetter, Sharon
A1  - Wang, Fenglin
A1  - Weathersby, Stephen
A1  - Yoneda, Charles
A1  - Centurion, Martin
A1  - Wang, Xijie
T1  - Diffractive imaging of a rotational wavepacket in nitrogen molecules
with femtosecond megaelectronvolt electron pulses
JF  - Nature Communications
N2  - Imaging changes in molecular geometries on their natural femtosecond timescale with sub-Angstrom spatial precision is one of the critical challenges in the chemical sciences, as the nuclear geometry changes determine the molecular reactivity. For photoexcited molecules, the nuclear dynamics determine the photoenergy conversion path and efficiency. Here we report a gas-phase electron diffraction experiment using megaelectronvolt (MeV) electrons, where we captured the rotational wavepacket dynamics of nonadiabatically laser-aligned nitrogen molecules. We achieved a combination of 100 fs root-mean-squared temporal resolution and sub-Angstrom (0.76 angstrom) spatial resolution that makes it possible to resolve the position of the nuclei within the molecule. In addition, the diffraction patterns reveal the angular distribution of the molecules, which changes from prolate (aligned) to oblate (anti-aligned) in 300 fs. Our results demonstrate a significant and promising step towards making atomically resolved movies of molecular reactions.
Y1  - 2016
U6  - https://doi.org/10.1038/ncomms11232
SN  - 2041-1723
VL  - 7
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Yang, Jie
A1  - Guehr, Markus
A1  - Vecchione, Theodore
A1  - Robinson, Matthew Scott
A1  - Li, Renkai
A1  - Hartmann, Nick
A1  - Shen, Xiaozhe
A1  - Coffee, Ryan
A1  - Corbett, Jeff
A1  - Fry, Alan
A1  - Gaffney, Kelly
A1  - Gorkhover, Tais
A1  - Hast, Carsten
A1  - Jobe, Keith
A1  - Makasyuk, Igor
A1  - Reid, Alexander
A1  - Robinson, Joseph
A1  - Vetter, Sharon
A1  - Wang, Fenglin
A1  - Weathersby, Stephen
A1  - Yoneda, Charles
A1  - Wang, Xijie
A1  - Centurion, Martin
T1  - Femtosecond gas phase electron diffraction with MeV electrons
N2  - We present results on ultrafast gas electron diffraction (UGED) experiments with femtosecond resolution using the MeV electron gun at SLAC National Accelerator Laboratory. UGED is a promising method to investigate molecular dynamics in the gas phase because electron pulses can probe the structure with a high spatial resolution. Until recently, however, it was not possible for UGED to reach the relevant timescale for the motion of the nuclei during a molecular reaction. Using MeV electron pulses has allowed us to overcome the main challenges in reaching femtosecond resolution, namely delivering short electron pulses on a gas target, overcoming the effect of velocity mismatch between pump laser pulses and the probe electron pulses, and maintaining a low timing jitter. At electron kinetic energies above 3 MeV, the velocity mismatch between laser and electron pulses becomes negligible. The relativistic electrons are also less susceptible to temporal broadening due to the Coulomb force. One of the challenges of diffraction with relativistic electrons is that the small de Broglie wavelength results in very small diffraction angles. In this paper we describe the new setup and its characterization, including capturing static diffraction patterns of molecules in the gas phase, finding time-zero with sub-picosecond accuracy and first time-resolved diffraction experiments. The new device can achieve a temporal resolution of 100 fs root-mean-square, and sub-angstrom spatial resolution. The collimation of the beam is sufficient to measure the diffraction pattern, and the transverse coherence is on the order of 2 nm. Currently, the temporal resolution is limited both by the pulse duration of the electron pulse on target and by the timing jitter, while the spatial resolution is limited by the average electron beam current and the signal-to-noise ratio of the detection system. We also discuss plans for improving both the temporal resolution and the spatial resolution.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 326 
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-394989
ER  - 
TY  - JOUR
A1  - Yang, Jie
A1  - Gühr, Markus
A1  - Vecchione, Theodore
A1  - Robinson, Matthew Scott
A1  - Li, Renkai
A1  - Hartmann, Nick
A1  - Shen, Xiaozhe
A1  - Coffee, Ryan
A1  - Corbett, Jeff
A1  - Fry, Alan
A1  - Gaffney, Kelly
A1  - Gorkhover, Tais
A1  - Hast, Carsten
A1  - Jobe, Keith
A1  - Makasyuk, Igor
A1  - Reid, Alexander
A1  - Robinson, Joseph
A1  - Vetter, Sharon
A1  - Wang, Fenglin
A1  - Weathersby, Stephen
A1  - Yoneda, Charles
A1  - Wang, Xijie
A1  - Centurion, Martin
T1  - Femtosecond gas phase electron diffraction with MeV electrons
JF  - Faraday discussions
N2  - We present results on ultrafast gas electron diffraction (UGED) experiments with femtosecond resolution using the MeV electron gun at SLAC National Accelerator Laboratory. UGED is a promising method to investigate molecular dynamics in the gas phase because electron pulses can probe the structure with a high spatial resolution. Until recently, however, it was not possible for UGED to reach the relevant timescale for the motion of the nuclei during a molecular reaction. Using MeV electron pulses has allowed us to overcome the main challenges in reaching femtosecond resolution, namely delivering short electron pulses on a gas target, overcoming the effect of velocity mismatch between pump laser pulses and the probe electron pulses, and maintaining a low timing jitter. At electron kinetic energies above 3 MeV, the velocity mismatch between laser and electron pulses becomes negligible. The relativistic electrons are also less susceptible to temporal broadening due to the Coulomb force. One of the challenges of diffraction with relativistic electrons is that the small de Broglie wavelength results in very small diffraction angles. In this paper we describe the new setup and its characterization, including capturing static diffraction patterns of molecules in the gas phase, finding time-zero with sub-picosecond accuracy and first time-resolved diffraction experiments. The new device can achieve a temporal resolution of 100 fs root-mean-square, and sub-angstrom spatial resolution. The collimation of the beam is sufficient to measure the diffraction pattern, and the transverse coherence is on the order of 2 nm. Currently, the temporal resolution is limited both by the pulse duration of the electron pulse on target and by the timing jitter, while the spatial resolution is limited by the average electron beam current and the signal-to-noise ratio of the detection system. We also discuss plans for improving both the temporal resolution and the spatial resolution.
Y1  - 2016
U6  - https://doi.org/10.1039/c6fd00071a
SN  - 1359-6640
SN  - 1364-5498
VL  - 194
SP  - 563
EP  - 581
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Chen, Yao
A1  - Wang, Guang
A1  - Wang, Xiao-yu
A1  - Ma, Zheng-lai
A1  - Chen, You-peng
A1  - Chuai, Manli
A1  - von Websky, Karoline
A1  - Hocher, Berthold
A1  - Yang, Xuesong
T1  - Effects of high salt-exposure on the development of retina and lens in 5.5-Day Chick Embryo
JF  - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology
N2  - Background/Aims: Excess maternal salt intake during pregnancy may alter fetal development. However; our knowledge on how an increased salt intake during pregnancy influences fetal eye development is limited. In this study, we investigated the effects of high salt treatment on the developing eyes in chick embryos, especially focusing on the development of the retina and the lens. Methods: 5.5 day chick embryos were exposed to 280mosm/l (n=17), or 300mosm/l (n=16) NaCl. The treated embryos were then incubated for 96 hours before they were fixed with 4% paraformaldehyde for H&E staining, whole mount embryo immunostaining and TUNEL staining. BrdU and PH3 incorporation experiments were performed on the chick embryos after high salt treatment. RT-PCR analyses were conducted from chick retina tissues. Results: We demonstrated that high-salt treatment altered the size of eyes in chick embryos, induced malformation of the eyes and impaired the development of the lens and the retina. We found an impaired expression of Paired box 6 (PAX6) and neuronal cells in the developing retina as revealed by neurofilament immunofluorescent staining. There was a reduction in the number of BrdU-positive cells and PH3-positive cells in the retina, indicating an impaired cell proliferation with high salt treatment. High salt treatment also resulted in an increased number of TUNEL-positive cells in the retina, indicating a higher amount of cell death. RT-PCR data displayed that the expression of the pro-apoptotic molecule nerve growth factor (NGF) in chick retina was increased and CyclinD1 was reduced with high-salt treatment. The size of the lens was reduced and Pax6 expression in the lens was significantly inhibited. High salt treatment was detrimental to the migration of neural crest cells. Conclusion: Taken together; our study demonstrated that high salt exposure of 5.5 day chick embryos led to an impairment of retina and lens development, possibly through interfering with Pax6 expression.
KW  - Chick embryos
KW  - High osmolarity
KW  - Retina
KW  - Lens
KW  - Pax6
Y1  - 2014
U6  - https://doi.org/10.1159/000363044
SN  - 1015-8987
SN  - 1421-9778
VL  - 34
IS  - 3
SP  - 804
EP  - 817
PB  - Karger
CY  - Basel
ER  - 
TY  - JOUR
A1  - Yang, Jiongjiong
A1  - Wang, Aobing
A1  - Yan, Ming
A1  - Zhu, Zijian
A1  - Chen, Cheng
A1  - Wang, Yizhou
T1  - Distinct processing for pictures of animals and objects Evidence from eye movements
JF  - Emotion : a new journal from the American Psychological Association
N2  - Many studies have suggested that emotional stimuli orient and engage attention. There is also evidence that animate stimuli, such as those from humans and animals, cause attentional bias. However, categorical and emotional factors are usually mixed, and it is unclear to what extent human context influences attentional allocation. To address this issue, we tracked participants' eye movements while they viewed pictures with animals and inanimate images (i.e., category) as focal objects. These pictures had either negative or neutral emotional valence, and either human body parts or nonhuman parts were near the focal objects (i.e., context). The picture's valence, arousal, position, size, and most of the low-level visual features were matched across categories. The results showed that nonhuman animals were more likely to be attended to and to be attended to for longer times than inanimate objects. The same pattern held for the human contexts (vs. nonhuman contexts). The effects of emotional valence, category, and context interacted. Specifically, in images with a negative valence, focal animals and objects with human context had comparable numbers of gaze fixations and gaze duration. These results highlighted the attentional bias to animate parts of a picture and clarified that the effects of category, valence, and picture context interacted to influence attentional allocation.
KW  - emotion
KW  - category
KW  - attention
KW  - eye-tracking
Y1  - 2012
U6  - https://doi.org/10.1037/a0026848
SN  - 1528-3542
VL  - 12
IS  - 3
SP  - 540
EP  - 551
PB  - American Psychological Association
CY  - Washington
ER  - 
TY  - JOUR
A1  - Wilkin, Kyle J.
A1  - Parrish, Robert M.
A1  - Yang, Jie
A1  - Wolf, Thomas J. A.
A1  - Nunes, J. Pedro F.
A1  - Gühr, Markus
A1  - Li, Renkai
A1  - Shen, Xiaozhe
A1  - Zheng, Qiang
A1  - Wang, Xijie
A1  - Martinez, Todd J.
A1  - Centurion, Martin
T1  - Diffractive imaging of dissociation and ground-state dynamics in a complex molecule
JF  - Physical review : A, Atomic, molecular, and optical physics
N2  - We have investigated the structural dynamics in photoexcited 1,2-diiodotetrafluoroethane molecules (C2F4I2) in the gas phase experimentally using ultrafast electron diffraction and theoretically using FOMO-CASCI excited-state dynamics simulations. The molecules are excited by an ultraviolet femtosecond laser pulse to a state characterized by a transition from the iodine 5p perpendicular to orbital to a mixed 5p parallel to sigma hole and CF2 center dot antibonding orbital, which results in the cleavage of one of the carbon-iodine bonds. We have observed, with sub-Angstrom resolution, the motion of the nuclear wave packet of the dissociating iodine atom followed by coherent vibrations in the electronic ground state of the C2F4I radical. The radical reaches a stable classical (nonbridged) structure in less than 200 fs.
Y1  - 2019
U6  - https://doi.org/10.1103/PhysRevA.100.023402
SN  - 2469-9926
SN  - 2469-9934
VL  - 100
IS  - 2
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Gao, Lin-rui
A1  - Wang, Guang
A1  - Zhang, Jing
A1  - Li, Shuai
A1  - Chuai, Manli
A1  - Bao, Yongping
A1  - Hocher, Berthold
A1  - Yang, Xuesong
T1  - High salt-induced excess reactive oxygen species production resulted in heart tube malformation during gastrulation
JF  - Journal of Cellular Physiology
N2  - An association has been proved between high salt consumption and cardiovascular mortality. In vertebrates, the heart is the first functional organ to be formed. However, it is not clear whether high-salt exposure has an adverse impact on cardiogenesis. Here we report high-salt exposure inhibited basement membrane breakdown by affecting RhoA, thus disturbing the expression of Slug/E-cadherin/N-cadherin/Laminin and interfering with mesoderm formation during the epithelial-mesenchymal transition(EMT). Furthermore, the DiI(+) cell migration trajectory in vivo and scratch wound assays in vitro indicated that high-salt exposure restricted cell migration of cardiac progenitors, which was caused by the weaker cytoskeleton structure and unaltered corresponding adhesion junctions at HH7. Besides, down-regulation of GATA4/5/6, Nkx2.5, TBX5, and Mef2c and up-regulation of Wnt3a/-catenin caused aberrant cardiomyocyte differentiation at HH7 and HH10. High-salt exposure also inhibited cell proliferation and promoted apoptosis. Most importantly, our study revealed that excessive reactive oxygen species(ROS)generated by high salt disturbed the expression of cardiac-related genes, detrimentally affecting the above process including EMT, cell migration, differentiation, cell proliferation and apoptosis, which is the major cause of malformation of heart tubes.
KW  - cardiac progenitor migration and differentiation
KW  - chick embryo
KW  - heart tube
KW  - high salt
KW  - reactive oxygen species
Y1  - 2018
U6  - https://doi.org/10.1002/jcp.26528
SN  - 0021-9541
SN  - 1097-4652
VL  - 233
IS  - 9
SP  - 7120
EP  - 7133
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Yang, Jie
A1  - Zhu, Xiaolei
A1  - Wolf, Thomas J. A.
A1  - Li, Zheng
A1  - Nunes, João Pedro Figueira
A1  - Coffee, Ryan
A1  - Cryan, James P.
A1  - Gühr, Markus
A1  - Hegazy, Kareem
A1  - Heinz, Tony F.
A1  - Jobe, Keith
A1  - Li, Renkai
A1  - Shen, Xiaozhe
A1  - Veccione, Theodore
A1  - Weathersby, Stephen
A1  - Wilkin, Kyle J.
A1  - Yoneda, Charles
A1  - Zheng, Qiang
A1  - Martinez, Todd J.
A1  - Centurion, Martin
A1  - Wang, Xijie
T1  - Imaging CF3I conical intersection and photodissociation dynamics with ultrafast electron diffraction
JF  - Science
N2  - Conical intersections play a critical role in excited-state dynamics of polyatomic molecules because they govern the reaction pathways of many nonadiabatic processes. However, ultrafast probes have lacked sufficient spatial resolution to image wave-packet trajectories through these intersections directly. Here, we present the simultaneous experimental characterization of one-photon and two-photon excitation channels in isolated CF3I molecules using ultrafast gas-phase electron diffraction. In the two-photon channel, we have mapped out the real-space trajectories of a coherent nuclear wave packet, which bifurcates onto two potential energy surfaces when passing through a conical intersection. In the one-photon channel, we have resolved excitation of both the umbrella and the breathing vibrational modes in the CF3 fragment in multiple nuclear dimensions. These findings benchmark and validate ab initio nonadiabatic dynamics calculations.
Y1  - 2018
U6  - https://doi.org/10.1126/science.aat0049
SN  - 0036-8075
SN  - 1095-9203
VL  - 361
IS  - 6397
SP  - 64
EP  - 67
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Abdo, A. A.
A1  - Ackermann, Margit
A1  - Ajello, M.
A1  - Allafort, A. J.
A1  - Baldini, L.
A1  - Ballet, J.
A1  - Barbiellini, G.
A1  - Baring, M. G.
A1  - Bastieri, D.
A1  - Bechtol, K. C.
A1  - Bellazzini, R.
A1  - Berenji, B.
A1  - Blandford, R. D.
A1  - Bloom, E. D.
A1  - Bonamente, E.
A1  - Borgland, A. W.
A1  - Bouvier, A.
A1  - Brandt, T. J.
A1  - Bregeon, Johan
A1  - Brez, A.
A1  - Brigida, M.
A1  - Bruel, P.
A1  - Buehler, R.
A1  - Buson, S.
A1  - Caliandro, G. A.
A1  - Cameron, R. A.
A1  - Cannon, A.
A1  - Caraveo, P. A.
A1  - Carrigan, Svenja
A1  - Casandjian, J. M.
A1  - Cavazzuti, E.
A1  - Cecchi, C.
A1  - Celik, O.
A1  - Charles, E.
A1  - Chekhtman, A.
A1  - Cheung, C. C.
A1  - Chiang, J.
A1  - Ciprini, S.
A1  - Claus, R.
A1  - Cohen-Tanugi, J.
A1  - Conrad, Jan
A1  - Cutini, S.
A1  - Dermer, C. D.
A1  - de Palma, F.
A1  - do Couto e Silva, E.
A1  - Drell, P. S.
A1  - Dubois, R.
A1  - Dumora, D.
A1  - Favuzzi, C.
A1  - Fegan, S. J.
A1  - Ferrara, E. C.
A1  - Focke, W. B.
A1  - Fortin, P.
A1  - Frailis, M.
A1  - Fuhrmann, L.
A1  - Fukazawa, Y.
A1  - Funk, S.
A1  - Fusco, P.
A1  - Gargano, F.
A1  - Gasparrini, D.
A1  - Gehrels, N.
A1  - Germani, S.
A1  - Giglietto, N.
A1  - Giordano, F.
A1  - Giroletti, M.
A1  - Glanzman, T.
A1  - Godfrey, G.
A1  - Grenier, I. A.
A1  - Guillemot, L.
A1  - Guiriec, S.
A1  - Hayashida, M.
A1  - Hays, E.
A1  - Horan, D.
A1  - Hughes, R. E.
A1  - Johannesson, G.
A1  - Johnson, A. S.
A1  - Johnson, W. N.
A1  - Kadler, M.
A1  - Kamae, T.
A1  - Katagiri, H.
A1  - Kataoka, J.
A1  - Knoedlseder, J.
A1  - Kuss, M.
A1  - Lande, J.
A1  - Latronico, L.
A1  - Lee, S. -H.
A1  - Lemoine-Goumard, M.
A1  - Longo, F.
A1  - Loparco, F.
A1  - Lott, B.
A1  - Lovellette, M. N.
A1  - Lubrano, P.
A1  - Madejski, G. M.
A1  - Makeev, A.
A1  - Max-Moerbeck, W.
A1  - Mazziotta, Mario Nicola
A1  - McEnery, J. E.
A1  - Mehault, J.
A1  - Michelson, P. F.
A1  - Mitthumsiri, W.
A1  - Mizuno, T.
A1  - Moiseev, A. A.
A1  - Monte, C.
A1  - Monzani, M. E.
A1  - Morselli, A.
A1  - Moskalenko, I. V.
A1  - Murgia, S.
A1  - Naumann-Godo, M.
A1  - Nishino, S.
A1  - Nolan, P. L.
A1  - Norris, J. P.
A1  - Nuss, E.
A1  - Ohsugi, T.
A1  - Okumura, A.
A1  - Omodei, N.
A1  - Orlando, E.
A1  - Ormes, J. F.
A1  - Paneque, D.
A1  - Panetta, J. H.
A1  - Parent, D.
A1  - Pavlidou, V.
A1  - Pearson, T. J.
A1  - Pelassa, V.
A1  - Pepe, M.
A1  - Pesce-Rollins, M.
A1  - Piron, F.
A1  - Porter, T. A.
A1  - Raino, S.
A1  - Rando, R.
A1  - Razzano, M.
A1  - Readhead, A.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Richards, J. L.
A1  - Ripken, J.
A1  - Ritz, S.
A1  - Roth, M.
A1  - Sadrozinski, H. F. -W.
A1  - Sanchez, D.
A1  - Sander, A.
A1  - Scargle, J. D.
A1  - Sgro, C.
A1  - Siskind, E. J.
A1  - Smith, P. D.
A1  - Spandre, G.
A1  - Spinelli, P.
A1  - Stawarz, L.
A1  - Stevenson, M.
A1  - Strickman, M. S.
A1  - Sokolovsky, K. V.
A1  - Suson, D. J.
A1  - Takahashi, H.
A1  - Takahashi, T.
A1  - Tanaka, T.
A1  - Thayer, J. B.
A1  - Thayer, J. G.
A1  - Thompson, D. J.
A1  - Tibaldo, L.
A1  - Torres, F.
A1  - Tosti, G.
A1  - Tramacere, A.
A1  - Uchiyama, Y.
A1  - Usher, T. L.
A1  - Vandenbroucke, J.
A1  - Vasileiou, V.
A1  - Vilchez, N.
A1  - Vitale, V.
A1  - Waite, A. P.
A1  - Wang, P.
A1  - Wehrle, A. E.
A1  - Winer, B. L.
A1  - Wood, K. S.
A1  - Yang, Z.
A1  - Ylinen, T.
A1  - Zensus, J. A.
A1  - Ziegler, M.
A1  - Aleksic, J.
A1  - Antonelli, L. A.
A1  - Antoranz, P.
A1  - Backes, Michael
A1  - Barrio, J. A.
A1  - Gonzalez, J. Becerra
A1  - Bednarek, W.
A1  - Berdyugin, A.
A1  - Berger, K.
A1  - Bernardini, E.
A1  - Biland, A.
A1  - Blanch Bigas, O.
A1  - Bock, R. K.
A1  - Boller, A.
A1  - Bonnoli, G.
A1  - Bordas, Pol
A1  - Tridon, D. Borla
A1  - Bosch-Ramon, Valentin
A1  - Bose, D.
A1  - Braun, I.
A1  - Bretz, T.
A1  - Camara, M.
A1  - Carmona, E.
A1  - Carosi, A.
A1  - Colin, P.
A1  - Colombo, E.
A1  - Contreras, J. L.
A1  - Cortina, J.
A1  - Covino, S.
A1  - Dazzi, F.
A1  - de Angelis, A.
A1  - del Pozo, E. De Cea
A1  - De Lotto, B.
A1  - De Maria, M.
A1  - De Sabata, F.
A1  - Mendez, C. Delgado
A1  - Ortega, A. Diago
A1  - Doert, M.
A1  - Dominguez, A.
A1  - Prester, Dijana Dominis
A1  - Dorner, D.
A1  - Doro, M.
A1  - Elsaesser, D.
A1  - Ferenc, D.
A1  - Fonseca, M. V.
A1  - Font, L.
A1  - Lopen, R. J. Garcia
A1  - Garczarczyk, M.
A1  - Gaug, M.
A1  - Giavitto, G.
A1  - Godinovi, N.
A1  - Hadasch, D.
A1  - Herrero, A.
A1  - Hildebrand, D.
A1  - Hoehne-Moench, D.
A1  - Hose, J.
A1  - Hrupec, D.
A1  - Jogler, T.
A1  - Klepser, S.
A1  - Kraehenbuehl, T.
A1  - Kranich, D.
A1  - Krause, J.
A1  - La Barbera, A.
A1  - Leonardo, E.
A1  - Lindfors, E.
A1  - Lombardi, S.
A1  - Lopez, M.
A1  - Lorenz, E.
A1  - Majumdar, P.
A1  - Makariev, E.
A1  - Maneva, G.
A1  - Mankuzhiyil, N.
A1  - Mannheim, K.
A1  - Maraschi, L.
A1  - Mariotti, M.
A1  - Martinez, M.
A1  - Mazin, D.
A1  - Meucci, M.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Miyamoto, H.
A1  - Moldon, J.
A1  - Moralejo, A.
A1  - Nieto, D.
A1  - Nilsson, K.
A1  - Orito, R.
A1  - Oya, I.
A1  - Paoletti, R.
A1  - Paredes, J. M.
A1  - Partini, S.
A1  - Pasanen, M.
A1  - Pauss, F.
A1  - Pegna, R. G.
A1  - Perez-Torres, M. A.
A1  - Persic, M.
A1  - Peruzzo, J.
A1  - Pochon, J.
A1  - Moroni, P. G. Prada
A1  - Prada, F.
A1  - Prandini, E.
A1  - Puchades, N.
A1  - Puljak, I.
A1  - Reichardt, T.
A1  - Reinthal, R.
A1  - Rhode, W.
A1  - Ribo, M.
A1  - Rico, J.
A1  - Rissi, M.
A1  - Ruegamer, S.
A1  - Saggion, A.
A1  - Saito, K.
A1  - Saito, T. Y.
A1  - Salvati, M.
A1  - Sanchez-Conde, M.
A1  - Satalecka, K.
A1  - Scalzotto, V.
A1  - Scapin, V.
A1  - Schultz, C.
A1  - Schweizer, T.
A1  - Shayduk, M.
A1  - Shore, S. N.
A1  - Sierpowska-Bartosik, A.
A1  - Sillanpaa, A.
A1  - Sitarek, J.
A1  - Sobczynska, D.
A1  - Spanier, F.
A1  - Spiro, S.
A1  - Stamerra, A.
A1  - Steinke, B.
A1  - Storz, J.
A1  - Strah, N.
A1  - Struebig, J. C.
A1  - Suric, T.
A1  - Takalo, L. O.
A1  - Tavecchio, F.
A1  - Temnikov, P.
A1  - Terzic, T.
A1  - Tescaro, D.
A1  - Teshima, M.
A1  - Vankov, H.
A1  - Wagner, R. M.
A1  - Weitzel, Q.
A1  - Zabalza, V.
A1  - Zandanel, F.
A1  - Zanin, R.
A1  - Acciari, V. A.
A1  - Arlen, T.
A1  - Aune, T.
A1  - Benbow, W.
A1  - Boltuch, D.
A1  - Bradbury, S. M.
A1  - Buckley, J. H.
A1  - Bugaev, V.
A1  - Cannon, A.
A1  - Cesarini, A.
A1  - Ciupik, L.
A1  - Cui, W.
A1  - Dickherber, R.
A1  - Errando, M.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Finnegan, G.
A1  - Fortson, L.
A1  - Furniss, A.
A1  - Galante, N.
A1  - Gall, D.
A1  - Gillanders, G. H.
A1  - Godambe, S.
A1  - Grube, J.
A1  - Guenette, R.
A1  - Gyuk, G.
A1  - Hanna, D.
A1  - Holder, J.
A1  - Huang, D.
A1  - Hui, C. M.
A1  - Humensky, T. B.
A1  - Kaaret, P.
A1  - Karlsson, N.
A1  - Kertzman, M.
A1  - Kieda, D.
A1  - Konopelko, A.
A1  - Krawczynski, H.
A1  - Krennrich, F.
A1  - Lang, M. J.
A1  - Maier, G.
A1  - McArthur, S.
A1  - McCann, A.
A1  - McCutcheon, M.
A1  - Moriarty, P.
A1  - Mukherjee, R.
A1  - Ong, R.
A1  - Otte, N.
A1  - Pandel, D.
A1  - Perkins, J. S.
A1  - Pichel, A.
A1  - Pohl, M.
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Reyes, L. C.
A1  - Reynolds, P. T.
A1  - Roache, E.
A1  - Rose, H. J.
A1  - Rovero, A. C.
A1  - Schroedter, M.
A1  - Sembroski, G. H.
A1  - Senturk, G. D.
A1  - Steele, D.
A1  - Swordy, S. P.
A1  - Tesic, G.
A1  - Theiling, M.
A1  - Thibadeau, S.
A1  - Varlotta, A.
A1  - Vincent, S.
A1  - Wakely, S. P.
A1  - Ward, J. E.
A1  - Weekes, T. C.
A1  - Weinstein, A.
A1  - Weisgarber, T.
A1  - Williams, D. A.
A1  - Wood, M.
A1  - Zitzer, B.
A1  - Villata, M.
A1  - Raiteri, C. M.
A1  - Aller, H. D.
A1  - Aller, M. F.
A1  - Arkharov, A. A.
A1  - Blinov, D. A.
A1  - Calcidese, P.
A1  - Chen, W. P.
A1  - Efimova, N. V.
A1  - Kimeridze, G.
A1  - Konstantinova, T. S.
A1  - Kopatskaya, E. N.
A1  - Koptelova, E.
A1  - Kurtanidze, O. M.
A1  - Kurtanidze, S. O.
A1  - Lahteenmaki, A.
A1  - Larionov, V. M.
A1  - Larionova, E. G.
A1  - Larionova, L. V.
A1  - Ligustri, R.
A1  - Morozova, D. A.
A1  - Nikolashvili, M. G.
A1  - Sigua, L. A.
A1  - Troitsky, I. S.
A1  - Angelakis, E.
A1  - Capalbi, M.
A1  - Carraminana, A.
A1  - Carrasco, L.
A1  - Cassaro, P.
A1  - de la Fuente, E.
A1  - Gurwell, M. A.
A1  - Kovalev, Y. Y.
A1  - Kovalev, Yu. A.
A1  - Krichbaum, T. P.
A1  - Krimm, H. A.
A1  - Leto, Paolo
A1  - Lister, M. L.
A1  - Maccaferri, G.
A1  - Moody, J. W.
A1  - Mori, Y.
A1  - Nestoras, I.
A1  - Orlati, A.
A1  - Pagani, C.
A1  - Pace, C.
A1  - Pearson, R.
A1  - Perri, M.
A1  - Piner, B. G.
A1  - Pushkarev, A. B.
A1  - Ros, E.
A1  - Sadun, A. C.
A1  - Sakamoto, T.
A1  - Tornikoski, M.
A1  - Yatsu, Y.
A1  - Zook, A.
T1  - Insights into the high-energy gamma-Ray emission of markarian 501 fromextensive multifrequency observations in the fermi era
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics
N2  - We report on the gamma-ray activity of the blazar Mrk 501 during the first 480 days of Fermi operation. We find that the average Large Area Telescope (LAT) gamma-ray spectrum of Mrk 501 can be well described by a single power-law function with a photon index of 1.78 +/- 0.03. While we observe relatively mild flux variations with the Fermi-LAT (within less than a factor of two), we detect remarkable spectral variability where the hardest observed spectral index within the LAT energy range is 1.52 +/- 0.14, and the softest one is 2.51 +/- 0.20. These unexpected spectral changes do not correlate with the measured flux variations above 0.3 GeV. In this paper, we also present the first results from the 4.5 month long multifrequency campaign (2009 March 15-August 1) on Mrk 501, which included the Very Long Baseline Array (VLBA), Swift, RXTE, MAGIC, and VERITAS, the F-GAMMA, GASP-WEBT, and other collaborations and instruments which provided excellent temporal and energy coverage of the source throughout the entire campaign. The extensive radio to TeV data set from this campaign provides us with the most detailed spectral energy distribution yet collected for this source during its relatively low activity. The average spectral energy distribution of Mrk 501 is well described by the standard one-zone synchrotron self-Compton (SSC) model. In the framework of this model, we find that the dominant emission region is characterized by a size less than or similar to 0.1 pc (comparable within a factor of few to the size of the partially resolved VLBA core at 15-43 GHz), and that the total jet power (similar or equal to 10(44) erg s(-1)) constitutes only a small fraction (similar to 10(-3)) of the Eddington luminosity. The energy distribution of the freshly accelerated radiating electrons required to fit the time-averaged data has a broken power-law form in the energy range 0.3 GeV-10 TeV, with spectral indices 2.2 and 2.7 below and above the break energy of 20 GeV. We argue that such a form is consistent with a scenario in which the bulk of the energy dissipation within the dominant emission zone of Mrk 501 is due to relativistic, proton-mediated shocks. We find that the ultrarelativistic electrons and mildly relativistic protons within the blazar zone, if comparable in number, are in approximate energy equipartition, with their energy dominating the jet magnetic field energy by about two orders of magnitude.
KW  - acceleration of particles
KW  - BL Lacertae objects: general
KW  - BL Lacertae objects: individual (Mrk 501)
KW  - galaxies: active
KW  - gamma rays: general
KW  - radiation mechanisms: non-thermal
Y1  - 2011
U6  - https://doi.org/10.1088/0004-637X/727/2/129
SN  - 0004-637X
VL  - 727
IS  - 2
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Wolf, Thomas J. A.
A1  - Sanchez, David M.
A1  - Yang, J.
A1  - Parrish, R. M.
A1  - Nunes, J. P. F.
A1  - Centurion, M.
A1  - Coffee, R.
A1  - Cryan, J. P.
A1  - Gühr, Markus
A1  - Hegazy, Kareem
A1  - Kirrander, Adam
A1  - Li, R. K.
A1  - Ruddock, J.
A1  - Shen, Xiaozhe
A1  - Vecchione, T.
A1  - Weathersby, S. P.
A1  - Weber, Peter M.
A1  - Wilkin, K.
A1  - Yong, Haiwang
A1  - Zheng, Q.
A1  - Wang, X. J.
A1  - Minitti, Michael P.
A1  - Martinez, Todd J.
T1  - The photochemical ring-opening of 1,3-cyclohexadiene imaged by ultrafast electron diffraction
JF  - Nature chemistry
N2  - The ultrafast photoinduced ring-opening of 1,3-cyclohexadiene constitutes a textbook example of electrocyclic reactions in organic chemistry and a model for photobiological reactions in vitamin D synthesis. Although the relaxation from the photoexcited electronic state during the ring-opening has been investigated in numerous studies, the accompanying changes in atomic distance have not been resolved. Here we present a direct and unambiguous observation of the ring-opening reaction path on the femtosecond timescale and subangstrom length scale using megaelectronvolt ultrafast electron diffraction. We followed the carbon-carbon bond dissociation and the structural opening of the 1,3-cyclohexadiene ring by the direct measurement of time-dependent changes in the distribution of interatomic distances. We observed a substantial acceleration of the ring-opening motion after internal conversion to the ground state due to a steepening of the electronic potential gradient towards the product minima. The ring-opening motion transforms into rotation of the terminal ethylene groups in the photoproduct 1,3,5-hexatriene on the subpicosecond timescale.
KW  - Organic chemistry
KW  - Photochemistry
KW  - Physical chemistry
KW  - Theoretical chemistry
Y1  - 2019
U6  - https://doi.org/10.1038/s41557-019-0252-7
SN  - 1755-4330
SN  - 1755-4349
VL  - 11
IS  - 6
SP  - 504
EP  - 509
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Müller, Katharina
A1  - Foerstendorf, Harald
A1  - Steudtner, Robin
A1  - Tsushima, Satoru
A1  - Kumke, Michael Uwe
A1  - Lefèvre, Grégory
A1  - Rothe, Jörg
A1  - Mason, Harris
A1  - Szabó, Zoltán
A1  - Yang, Ping
A1  - Adam, Christian K. R.
A1  - André, Rémi
A1  - Brennenstuhl, Katlen
A1  - Chiorescu, Ion
A1  - Cho, Herman M.
A1  - Creff, Gaëlle
A1  - Coppin, Frédéric
A1  - Dardenne, Kathy
A1  - Den Auwer, Christophe
A1  - Drobot, Björn
A1  - Eidner, Sascha
A1  - Hess, Nancy J.
A1  - Kaden, Peter
A1  - Kremleva, Alena
A1  - Kretzschmar, Jerome
A1  - Krüger, Sven
A1  - Platts, James A.
A1  - Panak, Petra
A1  - Polly, Robert
A1  - Powell, Brian A.
A1  - Rabung, Thomas
A1  - Redon, Roland
A1  - Reiller, Pascal E.
A1  - Rösch, Notker
A1  - Rossberg, André
A1  - Scheinost, Andreas C.
A1  - Schimmelpfennig, Bernd
A1  - Schreckenbach, Georg
A1  - Skerencak-Frech, Andrej
A1  - Sladkov, Vladimir
A1  - Solari, Pier Lorenzo
A1  - Wang, Zheming
A1  - Washton, Nancy M.
A1  - Zhang, Xiaobin
T1  - Interdisciplinary Round-Robin Test on molecular spectroscopy of the U(VI) Acetate System
JF  - ACS omega / American Chemical Society
N2  - A comprehensive molecular analysis of a simple aqueous complexing system. U(VI) acetate. selected to be independently investigated by various spectroscopic (vibrational, luminescence, X-ray absorption, and nuclear magnetic resonance spectroscopy) and quantum chemical methods was achieved by an international round-robin test (RRT). Twenty laboratories from six different countries with a focus on actinide or geochemical research participated and contributed to this scientific endeavor. The outcomes of this RRT were considered on two levels of complexity: first, within each technical discipline, conformities as well as discrepancies of the results and their sources were evaluated. The raw data from the different experimental approaches were found to be generally consistent. In particular, for complex setups such as accelerator-based X-ray absorption spectroscopy, the agreement between the raw data was high. By contrast, luminescence spectroscopic data turned out to be strongly related to the chosen acquisition parameters. Second, the potentials and limitations of coupling various spectroscopic and theoretical approaches for the comprehensive study of actinide molecular complexes were assessed. Previous spectroscopic data from the literature were revised and the benchmark data on the U(VI) acetate system provided an unambiguous molecular interpretation based on the correlation of spectroscopic and theoretical results. The multimethodologic approach and the conclusions drawn address not only important aspects of actinide spectroscopy but particularly general aspects of modern molecular analytical chemistry.
Y1  - 2019
U6  - https://doi.org/10.1021/acsomega.9b00164
SN  - 2470-1343
VL  - 4
IS  - 5
SP  - 8167
EP  - 8177
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Tang, Alan T.
A1  - Sullivan, Katie Rose
A1  - Hong, Courtney C.
A1  - Goddard, Lauren M.
A1  - Mahadevan, Aparna
A1  - Ren, Aileen
A1  - Pardo, Heidy
A1  - Peiper, Amy
A1  - Griffin, Erin
A1  - Tanes, Ceylan
A1  - Mattei, Lisa M.
A1  - Yang, Jisheng
A1  - Li, Li
A1  - Mericko-Ishizuka, Patricia
A1  - Shen, Le
A1  - Hobson, Nicholas
A1  - Girard, Romuald
A1  - Lightle, Rhonda
A1  - Moore, Thomas
A1  - Shenkar, Robert
A1  - Polster, Sean P.
A1  - Roedel, Claudia Jasmin
A1  - Li, Ning
A1  - Zhu, Qin
A1  - Whitehead, Kevin J.
A1  - Zheng, Xiangjian
A1  - Akers, Amy
A1  - Morrison, Leslie
A1  - Kim, Helen
A1  - Bittinger, Kyle
A1  - Lengner, Christopher J.
A1  - Schwaninger, Markus
A1  - Velcich, Anna
A1  - Augenlicht, Leonard
A1  - Abdelilah-Seyfried, Salim
A1  - Min, Wang
A1  - Marchuk, Douglas A.
A1  - Awad, Issam A.
A1  - Kahn, Mark L.
T1  - Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
JF  - Science Translational Medicine
N2  - Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial CCM is caused by genetic mutations in KRIT1, CCM2, or PDCD10. Disease onset is earlier and more severe in individuals with PDCD10 mutations. Recent studies have shown that lesions arise from excess mitogen-activated protein kinase kinase kinase 3 (MEKK3) signaling downstream of Toll-like receptor 4 (TLR4) stimulation by lipopolysaccharide derived from the gut microbiome. These findings suggest a gut-brain CCM disease axis but fail to define it or explain the poor prognosis of patients with PDCD10 mutations. Here, we demonstrate that the gut barrier is a primary determinant of CCM disease course, independent of microbiome configuration, that explains the increased severity of CCM disease associated with PDCD10 deficiency. Chemical disruption of the gut barrier with dextran sulfate sodium augments CCM formation in a mouse model, as does genetic loss of Pdcd10, but not Krit1, in gut epithelial cells. Loss of gut epithelial Pdcd10 results in disruption of the colonic mucosal barrier. Accordingly, loss of Mucin-2 or exposure to dietary emulsifiers that reduce the mucus barrier increases CCM burden analogous to loss of Pdcd10 in the gut epithelium. Last, we show that treatment with dexamethasone potently inhibits CCM formation in mice because of the combined effect of action at both brain endothelial cells and gut epithelial cells. These studies define a gut-brain disease axis in an experimental model of CCM in which a single gene is required for two critical components: gut epithelial function and brain endothelial signaling.
Y1  - 2019
U6  - https://doi.org/10.1126/scitranslmed.aaw3521
SN  - 1946-6234
SN  - 1946-6242
VL  - 11
IS  - 520
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Yang, Jie
A1  - Guehr, Markus
A1  - Shen, Xiaozhe
A1  - Li, Renkai
A1  - Vecchione, Theodore
A1  - Coffee, Ryan
A1  - Corbett, Jeff
A1  - Fry, Alan
A1  - Hartmann, Nick
A1  - Hast, Carsten
A1  - Hegazy, Kareem
A1  - Jobe, Keith
A1  - Makasyuk, Igor
A1  - Robinson, Joseph
A1  - Robinson, Matthew Scott
A1  - Vetter, Sharon
A1  - Weathersby, Stephen
A1  - Yoneda, Charles
A1  - Wang, Xijie
A1  - Centurion, Martin
T1  - Diffractive Imaging of Coherent Nuclear Motion in Isolated Molecules
JF  - Physical review letters
N2  - Observing the motion of the nuclear wave packets during a molecular reaction, in both space and time, is crucial for understanding and controlling the outcome of photoinduced chemical reactions. We have imaged the motion of a vibrational wave packet in isolated iodine molecules using ultrafast electron diffraction with relativistic electrons. The time-varying interatomic distance was measured with a precision 0.07 angstrom and temporal resolution of 230 fs full width at half maximum. The method is not only sensitive to the position but also the shape of the nuclear wave packet.
Y1  - 2016
U6  - https://doi.org/10.1103/PhysRevLett.117.153002
SN  - 0031-9007
SN  - 1079-7114
VL  - 117
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Gao, Guan-Nan
A1  - Wang, Min
A1  - Lin, Jun
A1  - Wu, Ning
A1  - Tan, Cheng-Ming
A1  - Kliem, Bernhard
A1  - Su, Yang
T1  - Radio observations of the fine structure inside a post-CME current sheet
JF  - Research in astronomy and astrophysics : a publication of the Chinese Astronomical Society and National Astronomical Observatories, Chinese Academy of Sciences
N2  - A solar radio burst was observed in a coronal mass ejection/flare event by the Solar Broadband Radio Spectrometer at the Huairou Solar Observing Station on 2004 December 1. The data exhibited various patterns of plasma motions, suggestive of the interaction between sunward moving plasmoids and the flare loop system during the impulsive phase of the event. In addition to the radio data, the associated white-light, H alpha, extreme ultraviolet light, and soft and hard X-rays were also studied.
KW  - Sun: coronal mass ejections (CMEs)
KW  - Sun: flares
KW  - Sun: solar radio bursts
KW  - Sun: magnetic reconnection
Y1  - 2014
U6  - https://doi.org/10.1088/1674-4527/14/7/006
SN  - 1674-4527
VL  - 14
IS  - 7
SP  - 843
EP  - 854
PB  - Chinese Astronomical Society and National Astronomical Observatories, Chinese Academy of Sciences
CY  - Beijing
ER  - 
TY  - THES
A1  - Wang, Yang
T1  - Role of the actin cytoskeleton in cellular morphogenesis at the shoot apical meristem of Arabidopsis thaliana
N2  - The morphogenesis of sessile plants is mainly driven by directional cell growth and cell division. The organization of their cytoskeleton and the mechanical properties of the cell wall greatly influence morphogenetic events in plants. It is well known that cortical microtubules (CMTs) contribute to directional growth by regulating the deposition of the cellulose microfibrils, as major cell wall fortifying elements. More recent findings demonstrate that mechanical stresses existing in cells and tissues influence microtubule organization. Also, in dividing cells, mechanical stress directions contribute to the orientation of the new cell wall. In comparison to the microtubule cytoskeleton, the role of the actin cytoskeleton in regulating shoot meristem morphogenesis has not been extensively studied. 
This thesis focuses on the functional relevance of the actin cytoskeleton during cell and tissue scale morphogenesis in the shoot apical meristem (SAM) of Arabidopsis thaliana. Visualization of transcriptional reporters indicates that ACTIN2 and ACTIN7 are two highly expressed actin genes in the SAM. A link between the actin cytoskeleton and SAM development derives from the observation that the act2-1 act7-1 double mutant has abnormal cell shape and perturbed phyllotactic patterns. Live-cell imaging of the actin cytoskeleton further shows that its organization correlates with cell shape, which indicates a potential role of actin in influencing cellular morphogenesis.   
In this thesis, a detailed characterization of the act2-1 act7-1 mutant reveals that perturbation of actin leads to more rectangular cellular geometries with more 90° cell internal angles, and higher incidences of four-way junctions (four cell boundaries intersecting together). This observation deviates from the conventional tricellular junctions found in epidermal cells. Quantitative cellular-level growth data indicates that such differences in the act2-1 act7-1 mutant arise due to the reduced accuracy in the placement of the new cell wall, as well as its mechanical maturation. Changes in cellular morphology observed in the act2-1 act7-1 mutant result in cell packing defects that subsequently compromise the flow of information among cells in the SAM.
N2  - Die Morphogenese sessiler Pflanzen wird hauptsächlich durch gerichtetes Zellwachstum und Zellteilung angetrieben. Die Organisation des Zytoskeletts und die mechanischen Eigenschaften der Zellwand haben großen Einfluss auf die morphogenetischen Vorgänge in Pflanzen. Es ist bekannt, dass kortikale Mikrotubuli (CMTs) zum gerichteten Wachstum beitragen, indem sie die Bildung von Zellulose-Mikrofibrillen als wichtige Elemente zur Stärkung der Zellwand regulieren. Neuere Erkenntnisse zeigen, dass mechanische Spannungen in den Zellen und Geweben die Organisation der Mikrotubuli beeinflussen. Bei der Zellteilung tragen auch die mechanischen Belastungsrichtungen zur Ausrichtung der neuen Zellwand bei. Im Vergleich zum Zytoskelett der Mikrotubuli ist die Rolle des Aktinzytoskeletts bei der Regulierung der Morphogenese des Sprossmeristems noch nicht umfassend untersucht worden.
Diese Arbeit befasst sich mit der funktionellen Bedeutung des Aktinzytoskeletts bei der Zell- und Gewebemorphogenese im Sprossapikalmeristem (SAM) von Arabidopsis thaliana. Die Visualisierung von Transkriptionsreportern zeigt, dass ACTIN2 und ACTIN7 zwei stark exprimierte Aktingene im SAM sind. Eine Verknüpfung zwischen dem Aktinzytoskelett und der Entwicklung des SAMs ergibt sich aus der Beobachtung, dass die act2-1 act7-1 Doppelmutante eine abnorme Zellform und ein gestörtes phyllotaktisches Muster aufweist. Die Lebend-Zell Aufnahmen des Aktinzytoskeletts zeigt außerdem, dass seine Organisation mit der Zellform korreliert, was auf eine mögliche Rolle des Aktins bei der Beeinflussung der zellulären Morphogenese hinweist. 
In dieser Arbeit wird anhand einer detaillierten Charakterisierung der act2-1 act7-1 Mutante gezeigt, dass eine Störung des Aktins zu rechteckigeren Zellgeometrien mit mehr 90°-Zellinnenwinkeln und einem höheren Vorkommen von Vierfach-Verbindungen (vier sich kreuzende Zellgrenzen) führt. Diese Beobachtung weicht von den konventionellen trizellulären Verbindungen der Epidermiszellen ab. Quantitative Wachstumsdaten auf zellulärer Ebene deuten darauf hin, dass diese Unterschiede in der act2-1 act7-1 Mutante auf die geringere Präzision bei der Platzierung der neuen Zellwand sowie auf ihre mechanische Reifung zurückzuführen sind. Die bei der act2-1 act7-1 Mutante beobachteten Veränderungen der Zellmorphologie führen zu Defekten in der Zellanordnung, die in der weiteren Folge den Informationsfluss zwischen den Zellen im SAM beeinträchtigen.
KW  - Arabidopsis
KW  - shoot apical meristem
KW  - actin
KW  - cell division
KW  - cell shape
KW  - morphogenesis
Y1  - 2022
U6  - https://doi.org/10.25932/publishup-55908
ER  -