TY  - JOUR
A1  - Matz, Timon W.
A1  - Wang, Yang
A1  - Kulshreshtha, Ritika
A1  - Sampathkumar, Arun
A1  - Nikoloski, Zoran
T1  - Topological properties accurately predict cell division events and organization of shoot apical meristem in Arabidopsis thaliana
JF  - Development : Company of Biologists
N2  - Cell division and the resulting changes to the cell organization affect the shape and functionality of all tissues. 
Thus, understanding the determinants of the tissue-wide changes imposed by cell division is a key question in developmental biology. 
Here, we use a network representation of live cell imaging data from shoot apical meristems (SAMs) in Arabidopsis thaliana to predict cell division events and their consequences at the tissue level. 
We show that a support vector machine classifier based on the SAM network properties is predictive of cell division events, with test accuracy of 76%, which matches that based on cell size alone. 
Furthermore, we demonstrate that the combination of topological and biological properties, including cell size, perimeter, distance and shared cell wall between cells, can further boost the prediction accuracy of resulting changes in topology triggered by cell division. 
Using our classifiers, we demonstrate the importance of microtubule-mediated cell-to-cell growth coordination in influencing tissue-level topology. 
Together, the results from our network-based analysis demonstrate a feedback mechanism between tissue topology and cell division in A. thaliana SAMs.
KW  - Arabidopsis thaliana
KW  - cell division
KW  - classification models
KW  - networks
KW  - shoot apical meristem
KW  - topology
Y1  - 2022
U6  - https://doi.org/10.1242/dev.201024
SN  - 0950-1991
SN  - 1477-9129
VL  - 149
IS  - 16
PB  - Company of Biologists
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Klein, Florian
A1  - Feldhahn, Niklas
A1  - Harder, S.
A1  - Wang, Hui
A1  - Wartenberg, Maria
A1  - Hofmann, W.-K.
A1  - Wernet, Peter
A1  - Sieber, Reiner
A1  - Müschen, Markus
T1  - The BCR-ABL1 kinase bypasses selection for the expressio of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells
Y1  - 2004
ER  -